Results 41 to 50 of about 3,175,008 (304)

Immune-Based Combination Therapies for Advanced Hepatocellular Carcinoma

, 2023
Riccardo Carloni,1,2 Simone Sabbioni,1,2 Alessandro Rizzo,3 Angela Dalia Ricci,4 Andrea Palloni,1,2 Cataldo Petrarota,3 Antonio Cusmai,3 Simona Tavolari,1,2 Gennaro Gadaleta-Caldarola,5,* Giovanni Brandi1,2,* 1Department of Specialized ...
Ricci AD, Sabbioni S, Rizzo A, Cusmai A, Carloni R, Tavolari S, Palloni A, Petrarota C, Gadaleta-Caldarola G, Brandi G   +9 more
core  

Prime editing of the common Familial Dysautonomia-causing c.2204 + 6T > C splicing mutation

Orphanet Journal of Rare Diseases
Familial Dysautonomia (FD, OMIM #223900) is a rare, life-threatening autosomal recessive neuropathy caused in 99.8% of patients by the c.2204 + 6T > C intronic mutation in the ELP1/IKAP gene. This substitution induces exon 20 skipping, leading to reduced
Laura Peretto, Mirko Pinotti, Dario Balestra   +2 more
doaj   +1 more source

Evidence‐Informed Multidisciplinary Consensus Guidance for the Psychosocial Care of Adolescents With High‐Risk Cancer: Recommendations From the Italian Association of Pediatric Hematology and Oncology

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Adolescents with high‐risk cancer face complex developmental, psychosocial, and ethical challenges that extend beyond disease‐directed treatment. Although international recommendations exist for communication, psychosocial care, pediatric palliative care, survivorship, and shared decision‐making, these have largely evolved within ...
Johanna M. C. Blom, Dorella Scarponi, Giulia Zucchetti, Teresa Perillo, Maria Montanaro, Elisa Marconi, Chiara Rutigliano, Paolo Colavero, Paola Quarello, Marina Bertolotti, Monica Cellini, Carlo Clerici, Maurizio Mascarin, Francesca Bomben, Andrea Ferrari, the expert workgroup   +15 more
wiley   +1 more source

Targeted anti-vascular therapies for ovarian cancer: current evidence [PDF]

, 2013
Ovarian cancer presents at advanced stage in around 75% of women, and despite improvements in treatments such as chemotherapy, the 5-year survival from the disease in women diagnosed between 1996 and 1999 in England and Wales was only 36%.
Mcneish, I., Gore, M., M Hall, Gore, M, C Gourley, Hall, M, Kaye, S, Gourley, C., Ledermann, J, McNeish, I, Jayson, G.; id_orcid, Gourley, C, G Jayson, Jayson, G., Kaye, S., Rustin, G, M Gore, J Ledermann, S Kaye, Perren, T, I McNeish, Hall, M., G Rustin, Rustin, G., Perren, T., T Perren, Jayson, G, Ledermann, J.   +27 more
core   +1 more source

Identification of a novel role of IL-13Rα2 in human Glioblastoma multiforme: interleukin-13 mediates signal transduction through AP-1 pathway

Journal of Translational Medicine, 2018
Background Previously, we have demonstrated that Interleukin 13 receptor alpha 2 (IL-13Rα2) is overexpressed in approximate 78% Glioblastoma multiforme (GBM) samples.
Rukmini Bhardwaj, Akiko Suzuki, Pamela Leland, Bharat H. Joshi, Raj K. Puri   +4 more
doaj   +1 more source

Integrated Analysis of Transcriptome and Secretome From Umbilical Cord Mesenchymal Stromal Cells Reveal New Mechanisms for the Modulation of Inflammation and Immune Activation

Frontiers in Immunology, 2020
Mesenchymal stromal cells (MSC) have been used in over 800 clinical trials with encouraging results in the field of transplant medicine and chronic inflammatory diseases.
Mónica Cruz-Barrera, Nathalia Flórez-Zapata, Nathalia Flórez-Zapata, Nicolás Lemus-Diaz, Carlos Medina, Cristian-Camilo Galindo, Lorena-Xiomara González-Acero, Luz Correa, Bernardo Camacho, Jens Gruber, Gustavo Salguero   +10 more
doaj   +1 more source

A physicochemical assessment of the thermal stability of dextrin–colistin conjugates

Scientific Reports, 2021
Attachment of polysaccharide carriers is increasingly being used to achieve precision delivery and improved effectiveness of protein and peptide drugs.
Emilie Chiron, Mathieu Varache, Joana Stokniene, David W. Thomas, Elaine L. Ferguson   +4 more
doaj   +1 more source

Early Body Mass Index z‐Score Change and Resolution of Severe Malnutrition in Children With Sickle Cell Anemia in a Low‐Income Setting: A Prospective Single‐Arm Extension Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Children with sickle cell anemia (SCA) in low‐income settings are at risk of severe malnutrition, but optimal nutritional management has not been established. We evaluated an intensified ready‐to‐use therapeutic food (RUTF) regimen in children with persistent severe malnutrition after initial treatment and assessed whether early ...
Safiya Gambo, Shehu Umar Abdullahi, Hassan Adam Murtala, Halima Kabir, Khadija A. Shamsu, Sari A. Acra, Virginia A. Stallings, Mark Rodeghier, Michael R. DeBaun, Lauren J. Klein   +9 more
wiley   +1 more source

Quantifying the effects of antibiotic treatment on the extracellular polymer network of antimicrobial resistant and sensitive biofilms using multiple particle tracking

npj Biofilms and Microbiomes, 2021
Novel therapeutics designed to target the polymeric matrix of biofilms requires innovative techniques to accurately assess their efficacy. Here, multiple particle tracking (MPT) was developed to characterize the physical and mechanical properties of ...
Lydia C. Powell, Muthanna Abdulkarim, Joana Stokniene, Qiu E. Yang, Timothy R. Walsh, Katja E. Hill, Mark Gumbleton, David W. Thomas   +7 more
doaj   +1 more source

Central Nervous System Tumors Among Infants in Canada: A Report From CYP‐C

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) tumors in infants are rare, pose unique clinical challenges, and lack large‐scale evidence‐based data to guide management. This study seeks to describe CNS tumors in Canadian infants and to compare their outcomes with those of older children.
Samuel Sassine, Hallie Coltin, Sylvia Cheng, Lucie Lafay‐Cousin, Vanan Issai Magimairajan, Craig Erker, Stéphanie Vairy, Lynette Bowes, Adam Fleming, Donna Johnston, Sarah McKillop, Roona Sinha, Julie Bennett, Christina Coleman, Laura Wheaton, Shayna Zelcer, Samuele Renzi, Thai Hoa Tran   +17 more
wiley   +1 more source