Results 21 to 30 of about 552,110 (322)

The Role of Sirt6 in Obesity and Diabetes

Frontiers in Physiology, 2018
Sirt6 is one of the sirtuin family members, a kind of NAD+-dependent histone deacetylase and ADP-ribose transferase enzyme. It has an important role in physiological and pathological processes, regulating aging, cancer, obesity, insulin resistance ...
Jiangying Kuang, Jiangying Kuang, Lei Chen, Lei Chen, Qin Tang, Qin Tang, Jinhang Zhang, Jinhang Zhang, Yanping Li, Yanping Li, Jinhan He, Jinhan He   +11 more
doaj   +1 more source

Adverse drug reactions

Disease-a-Month, 2017
Adverse events and adverse drug reactions are common in clinical practice. Side effects range from the common to the rare and may be confused with other mucocutaneous manifestations resulting from several medications to treat infections, other medical conditions, and in the clinical setting of oncologic treatment.
Zachary, Seagrave, Sonya, Bamba
openaire   +3 more sources

Action following the discovery of a global association between the whole genome and adverse event risk in a clinical drug-development programme [PDF]

, 2008
Observation of adverse drug reactions during drug development can cause closure of the whole programme. However, if association between the genotype and the risk of an adverse event is discovered, then it might suffice to exclude patients of certain ...
Breiman, Breslow, Dudbridge, Díaz-Uriarte, Efron, Fielding, Genkin, Graven, Hastie, Izmirlian, Kelly, Lindley, Park, Ripley, Roses, Roses, Tibshirani, Troyanskaya, Wille, Xiong, Yuan, Zaykin   +21 more
core   +1 more source

Safety Profile of Oxaliplatin in 3,687 Patients With Cancer in China: A Post-Marketing Surveillance Study

Frontiers in Oncology, 2021
BackgroundOxaliplatin (OXA), a third-generation platinum derivative, has become one of the main chemotherapeutic drugs for colorectal cancer and other cancers, but reports of adverse reactions are also increasing with the extensive application of OXA. In
Zaoqin Yu, Rui Huang, Li Zhao, Ximin Wang, Xiaofang Shangguan, Wei Li, Min Li, Xianguo Yin, Chengliang Zhang, Dong Liu   +9 more
doaj   +1 more source

Adverse drug reaction and organ damage: the liver [PDF]

, 2016
Drug-induced liver injury (Dili) is among the most challenging acute or chronic liver conditions to be handled by physicians. Despite its low incidence in the general population, Dili is a frequent cause of acute liver failure.
LICATA, Anna
core   +1 more source

Factors influencing medical staff’ s understanding of correct use for adrenaline in the treatment of severe allergic reactions: a literature review [PDF]

Xin yixue
Objective To understand the cognitive influencing factors affecting the use of epinephrine by medical staff for the treatment of serve allergic reactions and the current state of research at home and abroad.
YANG Jia, WANG Yan, DENG Li, LI Wenjun, DU Qian, LIU Songqing, XI Xin
doaj   +1 more source

Signalling paediatric side effects using an ensemble of simple study designs [PDF]

, 2014
Background: Children are frequently prescribed medication `o-label', meaning there has not been sucient testing of the medication to determine its safety or eectiveness.
Aickelin, U., Aickelin, U., Garibaldi, J.M., Garibaldi, J.M., Gibson, J.E., Gibson, J.E., Hubbard, R.B., Hubbard, R.B., Reps, J.M., Reps, J.M., Soria, D., Soria, D.   +11 more
core   +6 more sources

Value of patch tests in clindamycin-related drug eruptions [PDF]

, 2011
Background. Patch tests help to confirm the aetiology of the cutaneous adverse drug reactions involving delayed hypersensitivity mechanisms, but the results vary with the pattern of skin reaction and the culprit drug. Objectives.
Brites, MM, Canelas, MM, Gonçalo, Margarida, Pereira, N, Santiago, F   +4 more
core   +1 more source

Adverse drug reactions to tocolytic treatment for preterm labour: Prospective cohort study [PDF]

, 2009
Objective To evaluate the incidence of serious maternal complications after the use of various tocolytic drugs for the treatment of preterm labour in routine clinical situations. Design Prospective cohort study.
Duvekot, J.J. (Hans), Erwich, J.J.H.M., Famschobben, F., Geijn, H.P. (Herman) van, Gyselaers, W.J. (Wilfried), Hanssens, M. (Myriam), Harmark, L. (Linda), Heus, R. (Roel) de, Holsbeke, C.D. (Caroline) van, Mol, B.W.J. (Ben), Visser, G.H. (Gerhard Henk), Wolf, H. (Hans Uwe)   +11 more
core   +1 more source

Idiopathic non-histaminergic acquired angioedema: a case series and discussion of published clinical trials

Clinical and Translational Allergy, 2017
Background Idiopathic non-histaminergic acquired angioedema (InH-AAE) is a rare disease for which there are no available laboratory parameters to clearly define the disorder. Therapy is often difficult and various treatment options have been proposed. In
Martin Christian Bucher, Tatjana Petkovic, Arthur Helbling, Urs Christian Steiner   +3 more
doaj   +1 more source