Results 141 to 150 of about 103,305 (302)
Food Safety and Health, EarlyView.This comprehensive guide for the Agilent Seahorse XF HS Mini‐platform presents real‐time analysis of cellular energy metabolism across the mitochondrial stress test, glycolytic rate assay, and real‐time ATP rate assay, with applications in food safety and health and in metabolic disease.
Zhihao Liu +3 more
wiley +1 more source
Therapeutic targeting of circ‐CUX1/EWSR1/MAZ axis inhibits glycolysis and neuroblastoma progression
EMBO Molecular Medicine, 2019 Aerobic glycolysis is a hallmark of metabolic reprogramming in tumor progression. However, the mechanisms regulating glycolytic gene expression remain elusive in neuroblastoma (NB), the most common extracranial malignancy in childhood.
Huanhuan Li +14 more
doaj +1 more source
Functional optimization of the arterial network [PDF]
, 2014 We build an evolutionary scenario that explains how some crucial physiological constraints in the arterial network of mammals - i.e. hematocrit, vessels diameters and arterial pressure drops - could have been selected by evolution.
Mauroy, Benjamin, Moreau, Baptiste
core
International Journal of Cancer, EarlyView.What's New? Hypoxic regions and inflammatory Th17 cells in the tumor environment are both associated with poor prognosis in cervical cancer. However, synergistic mechanisms between hypoxia and Th17 cells remain elusive. This study demonstrated Th17–hypoxia‐driven mechanisms underlying cervical cancer progression.
Selina Gies +12 more
wiley +1 more source
Move beyond free radical theory of aging
iMetaOmics, EarlyView.Free radicals play a dual, dose‐dependent role in aging. Low levels activate the key sensor adenosine 5'‐monophosphate‐activated protein kinase (AMPK), promoting cell survival mechanisms like autophagy and enhancing mitochondrial health. High levels, however, push AMPK to initiate cell death pathways, such as apoptosis. This positions AMPK as a central
Xiaofeng Dai, Meilan Hu, Ruohan Lyu
wiley +1 more source
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Non‐small cell lung cancer (NSCLC) is the most common type of lung cancer, with a 5‐year survival rate of less than 20% and a high risk of recurrence despite advances in treatment. This study aimed to identify new therapeutic targets to increase the effectiveness of NSCLC treatments.
Rui‐Shi Wei +5 more
wiley +1 more source
Non‐Histone Lactylation: A New Frontier in Cerebral Ischemia‐Reperfusion Injury
Med Research, EarlyView.ABSTRACT Reperfusion therapy is the mainstay of treatment for ischemic stroke (IS) but frequently exacerbates secondary injury. Following cerebral ischemia and hypoxia, lactate accumulates markedly. Traditionally regarded as a metabolic byproduct, lactate has gained new significance with the discovery of protein lactylation. In addition to experimental
Minghui Tang +13 more
wiley +1 more source
Nano Select, EarlyView.Improving selectivity within therapeutic design is critical to ensure targeted delivery to brain tumors. Targeting the cellular membrane composition distinctive of the blood–brain barrier and brain cancer cells is explored in this review. Nanomedicine can be utilized for precise tumor recognition, and detailed mechanistic interactions of therapeutics ...
Mahnoor Kadri +2 more
wiley +1 more source
Evolutionary dynamics of the Warburg effect: Glycolysis as a collective action problem among cancer cells. [PDF]
, 2013 Archetti, Marco
core +1 more source
Identifying Subcellular Structure Components in Escherichia Coli by Crosslinking and SEC‐MS
PROTEOMICS, EarlyView.ABSTRACT Cells are comprised of a broad spectrum of structures that compartmentalize biochemical and signaling mechanisms. These structures can be comprised of many biomolecules, but especially lipids, proteins, and nucleic acids. Techniques are limited to quantify or discover new subcellular structures.
Rachel A. Victor +3 more
wiley +1 more source