Results 161 to 170 of about 103,305 (302)

Hcfc1 and Ogt Mediate Zebrafish CNS Regeneration Through Hippo/Yap Signalling

Cell Proliferation, EarlyView.
This work identifies Hcfc1 and Ogt as key regulators of zebrafish CNS regeneration through modulation of Hippo/Yap signalling. Loss of Hcfc1 or Ogt activity inhibition impairs regeneration, which is restored by Yap overexpression, revealing a new regulatory axis that enhances CNS regenerative capacity.
Priyanka P. Srivastava, Sidharth Bhasin, Poonam Sharma, Omkar Mahadeo Desai, Kshitiz Yadav, Ayushma, Rohan Chakraborty, Suhel Parvez, Rajesh Ramachandran, Shilpi Minocha   +9 more
wiley   +1 more source

Spotlight on aerobic glycolysis [PDF]

Nature Reviews Neuroscience, 2010
openaire   +1 more source

Quantitative assessment of gait alterations and variability in sulky‐driven Standardbred trotters after a standardised exercise test

Equine Veterinary Journal, EarlyView.
Abstract Background Assessment of equine metabolic and locomotory responses to quantified levels of physical exercise is needed to support the creation of tailored protocols for optimal training adaptation. The locomotory response to exercise in horses is not fully understood.
Rhana Mackie Aarts, Ineke Hillie Smit, Guilherme de Camargo Ferraz, Marie Rhodin, Filipe Manuel Serra Braganca, Elin Hernlund   +5 more
wiley   +1 more source

Anti‐cancer drugs targeting the NADH‐binding site of VDAC rewire channel electrophysiology and partially suppress cation selectivity

The FEBS Journal, EarlyView.
VA molecules alter VDAC1 gating by increasing anion flow and reducing cation permeability. In cancer cells, which rely on ER‐mitochondria Ca2+ transfer and overexpress VDAC1, this imbalance triggers bioenergetic stress, ROS buildup, and mitochondrial collapse, leading to cell death.
Stefano Conti‐Nibali, Giuseppe Battiato, Salvatore Antonio Maria Cubisino, Cristina Arrigoni, Marco Lolicato, Simona Reina, Vito De Pinto   +6 more
wiley   +1 more source

Proteostasis of organelles in aging and disease

The FEBS Journal, EarlyView.
Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi, Cansu Doğan, Dunja Petrović, Gülce Perçin, Seda Koyuncu, David Vilchez   +5 more
wiley   +1 more source

Untargeted Metabolomic and Lipidomic Profiles of Gingival Crevicular Fluid in the Context of Periodontitis

Journal of Clinical Periodontology, EarlyView.
ABSTRACT Aim(s) This cross‐sectional clinical study aimed to explore the untargeted metabolomic and lipidomic profiles in gingival crevicular fluid (GCF) obtained from healthy individuals and patients with periodontitis. Materials and Methods GCF was collected from 17 periodontally healthy and 19 periodontitis patients.
Caroline H. Henderzahs, Chiaki Yamada, Alexandr Morozov, Thelmalane Yalartai, Vanchit John, Hawra AlQallaf, Alexandru Movila   +6 more
wiley   +1 more source

Proteomic analysis of the zone of degeneration at the mitosis–meiosis transition stage in wild‐caught male catshark (Scyliorhinus canicula), correlated with an unusually high‐water temperature in the English Channel

Journal of Fish Biology, EarlyView.
Abstract In the context of current global change, variations in water temperature are one of the environmental conditions with serious consequences for marine life, including reproductive processes. In the small spotted catshark Scyliorhinus canicula, spermatogenesis occurs in spermatocysts composed of synchronously developing germ cells associated ...
Fabian Jeanne, Stanislas Pilet, Sean Heighton, Benoît Bernay, Pascal Sourdaine   +4 more
wiley   +1 more source

Epithelial‐Mesenchymal Transition, Immune Response, and Extracellular Matrix Remodelling in Oral Cancer

Journal of Oral Pathology &Medicine, EarlyView.
ABSTRACT Aim This retrospective study investigates the interplay between epithelial‐mesenchymal transition (EMT) and immune response within the tumor microenvironment (TME) of oral squamous cell carcinoma (OSCC). Methodology Immunohistochemistry was conducted on OSCC specimens to evaluate the expression of podoplanin (PDP), E‐cadherin (CDH1), vimentin (
Nicole Lonni, Camilla Kammer Pereira, Amanda Maciel Costa, Aline Hsiao Bona, Andressa Fernanda Paza Miguel, Elis Ângela Batistella, Daniella Serafin Couto Vieira, Elena Riet Correa Rivero   +7 more
wiley   +1 more source

HSPA12A maintains aerobic glycolytic homeostasis and Histone3 lactylation in cardiomyocytes to attenuate myocardial ischemia/reperfusion injury

JCI Insight
Myocardial ischemia/reperfusion (MI/R) injury is a major cause of adverse outcomes of revascularization following myocardial infarction. Anaerobic glycolysis during myocardial ischemia is well studied, but the role of aerobic glycolysis during the early ...
Wansu Yu, Qiuyue Kong, Surong Jiang, Yunfan Li, Zhaohe Wang, Qian Mao, Xiaojin Zhang, Qianhui Liu, Pengjun Zhang, Yuehua Li, Chuanfu Li, Zhengnian Ding, Li Liu   +12 more
doaj   +1 more source

Role and Molecular Mechanisms of Aerobic Glycolysis in Gastrointestinal Tumors. [PDF]

J Cancer
Lei Y, Peng L, Qin Z, Luo J, Luo Y, Fan Z, Wang J, Huang S, Zhao H, Lin S, Xiang L, Luo Y.   +11 more
europepmc   +1 more source