Results 181 to 190 of about 104,202 (300)

Bile acids enrichment fuel tumor aerobic glycolysis and immune evasion via stabilizing FXR-RARα. [PDF]

Front Immunol
Jiang H, Xiong W, Feng Y, Li X, Tan J, Zhang Z.   +5 more
europepmc   +1 more source

SLPI/FBW7/c‐Myc Axis Reduces Gemcitabine Sensitivity in PDAC by Enhancing Glycolysis and Impairing NK Cell Immunity

Cancer Science, EarlyView.
SLPI reduces the sensitivity of PDAC to gemcitabine by competing with FBW7 for binding to c‐Myc, thereby disrupting FBW7‐dependent ubiquitination and proteasomal degradation of c‐Myc, leading to increased c‐Myc stability and expression. SLPI knockdown could significantly increase gemcitabine sensitivity to gemcitabine‐induced direct cytotoxicity and NK
Haofei Chen, Xin Li, Weixiong Zhu, Yanxi Mu, Guoqing Zhang, Youheng Zhang, Yusheng Cheng, Wence Zhou   +7 more
wiley   +1 more source

HDAC6-mediated PFKL deacetylation enhances aerobic glycolysis and promotes VSMC proliferation. [PDF]

J Biol Chem
Hu ZK, Ren ZY, Pang JX, Li H, Yang MN, Dong LH.   +5 more
europepmc   +1 more source

Quantitative assessment of gait alterations and variability in sulky‐driven Standardbred trotters after a standardised exercise test

Equine Veterinary Journal, EarlyView.
Abstract Background Assessment of equine metabolic and locomotory responses to quantified levels of physical exercise is needed to support the creation of tailored protocols for optimal training adaptation. The locomotory response to exercise in horses is not fully understood.
Rhana Mackie Aarts, Ineke Hillie Smit, Guilherme de Camargo Ferraz, Marie Rhodin, Filipe Manuel Serra Braganca, Elin Hernlund   +5 more
wiley   +1 more source

TCF7L2/DEPDC1 axis contributes to tumor progression by promoting cell proliferation, aerobic glycolysis, and immunosuppression in pancreatic cancer. [PDF]

Clin Exp Med
Tasiheng Y, Kenjiabieke J, Tasiheng N, Adilijiang K, Cheng H.   +4 more
europepmc   +1 more source

Anti‐cancer drugs targeting the NADH‐binding site of VDAC rewire channel electrophysiology and partially suppress cation selectivity

The FEBS Journal, EarlyView.
VA molecules alter VDAC1 gating by increasing anion flow and reducing cation permeability. In cancer cells, which rely on ER‐mitochondria Ca2+ transfer and overexpress VDAC1, this imbalance triggers bioenergetic stress, ROS buildup, and mitochondrial collapse, leading to cell death.
Stefano Conti‐Nibali, Giuseppe Battiato, Salvatore Antonio Maria Cubisino, Cristina Arrigoni, Marco Lolicato, Simona Reina, Vito De Pinto   +6 more
wiley   +1 more source

Correction: Let-7b-5p inhibits breast cancer cell growth and metastasis via repression of hexokinase 2-mediated aerobic glycolysis. [PDF]

Cell Death Discov
Li L, Zhang X, Lin Y, Ren X, Xie T, Lin J, Wu S, Ye Q.   +7 more
europepmc   +1 more source

Persistent metabolic youth in the aging female brain [PDF]

, 2019
Bateman, Randall J., Benzinger, Tammie L.-S., Blazey, Tyler M., Couture, Lars E., Durbin, Tony J., Goyal, Manu S., Morris, John C., Raichle, Marcus E., Su, Yi, Vlassenko, Andrei G.   +9 more
core   +1 more source

Proteostasis of organelles in aging and disease

The FEBS Journal, EarlyView.
Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi, Cansu Doğan, Dunja Petrović, Gülce Perçin, Seda Koyuncu, David Vilchez   +5 more
wiley   +1 more source

RPL35A drives aerobic glycolysis and tumorigenesis by facilitating MYC-mediated SKP2 transcription. [PDF]

J Biol Chem
Yan L, Chen Y, Cao D, Hou M, Xue T, Zhang X.   +5 more
europepmc   +1 more source