Results 191 to 200 of about 104,202 (300)

Beyond the chaos: How architecture structures tumour biology

The FEBS Journal, EarlyView.
Tissue architecture shapes tumour initiation and progression through multiple interconnected layers continuously remodelled over time. This review outlines how physical forces, biochemical cues, cellular niches and systemic influences contribute to tumour evolution.
Lea Dörner, Catrin Lutz, Stefan Prekovic, Hendrik A. Messal   +3 more
wiley   +1 more source

METTL3 Potentiates Corneal Allograft Rejection via Increased Pro-Inflammatory Cytokine Production and Aerobic Glycolysis. [PDF]

Invest Ophthalmol Vis Sci
Yu H, Zeng F, Qu J, Liu X, Wei C, Wei C, Gao H.   +6 more
europepmc   +1 more source

Mitochondrial transfer in acute myeloid leukaemia and multiple myeloma: Mechanisms, consequences and potential therapeutic opportunities

The FEBS Journal, EarlyView.
Mitochondria can be transferred from bone marrow cells to cancer cells in acute myeloid leukaemia and multiple myeloma, boosting tumour energy production, growth, and drug resistance. This review highlights key transfer mechanisms and shows how targeting mitochondrial movement and dynamics may offer new therapeutic strategies to limit cancer ...
Ebubechukwu Nwarunma, Mark T. S. Williams   +1 more
wiley   +1 more source

FGF 13 functions as a regulator of the ERK/aerobic glycolysis axis in the inflammatory state during septic lung injury. [PDF]

Nat Commun
Zhu J, Wang J, Jiang C, Wang J, Zhou J, Tong G, Wu Y, Ou Z, Ye J, Shen E, Ke A, Li F, Jiang M, Ma J, Jin L, Li X, Cong W.   +16 more
europepmc   +1 more source

Fast & fuelious: the malate–aspartate shuttle in brown adipocyte lipid metabolism

The FEBS Journal, EarlyView.
Brown adipose tissue (BAT) produces heat in response to cold exposure, for which it relies on the coordination of aerobic and anaerobic metabolism. However, how reaction intermediates connect these two essential pathways is unclear. In this issue of The FEBS Journal, Veliova et al., report that the malate–aspartate shuttle (MAS) supports norepinephrine‐
Lukas Blaas, Alexander Bartelt
wiley   +1 more source

Fungal infection drives metabolic reprogramming in epithelial cells via aerobic glycolysis and an alternative TCA cycle shunt. [PDF]

Sci Adv
Pellon A, Sadeghi Nasab SD, Bidkhori G, Griffiths JS, Vaga S, Begum N, Blagojevic M, Sigh NK, Kotowicz NK, Uzochukwu I, Le Guennec A, Henley-Smith R, Gregson-Williams H, Clasen F, Pryce M, Karimpour N, Cook R, Anguita J, Richardson JP, Thavaraj S, Naglik JR, Shoaie S, Moyes DL.   +22 more
europepmc   +1 more source

Notch signaling suppresses glucose metabolism in mesenchymal progenitors to restrict osteoblast differentiation [PDF]

, 2018
Fanxin Long, Hart, Ismaili, Kitagawa, Megason, Seung-Yon Lee   +5 more
core   +2 more sources

Molecular Signatures of Peripheral and Central Dental Pulp Subpopulations in Response to Streptococcus mutans: A Bulk RNA‐Seq Analysis

International Endodontic Journal, EarlyView.
ABSTRACT Aim The dental pulp is an immunologically active tissue that responds dynamically to cariogenic challenge. Peripheral pulp cells adjacent to dentine encounter bacterial stimuli earlier than cells located in the central pulp. To investigate signalling and immune interactions, this study profiled the transcriptomes of dentine‐adherent cells ...
Sandra Pohl, Maximilian L. Huber, Tobias Akamp, Andreas Rosendahl, Melanie Linnebank, Lea Schreiber, Claudia Gebhard, Nicholas Strieder, Michael Rehli, Wolfgang Buchalla, Matthias Widbiller   +10 more
wiley   +1 more source

AARS1-mediated AKR1B10 lactylation stabilizes an aerobic glycolysis-positive feedback loop to drive lenvatinib resistance in hepatocellular carcinoma. [PDF]

Clin Transl Med
Liu Z, Yuan J, Su S, Han J, Zeng N, Ma Y, Chen N, Lv T.   +7 more
europepmc   +1 more source

Notch signaling regulates metabolic heterogeneity in glioblastoma stem cells [PDF]

, 2017
et al,, Si, Sheng
core   +2 more sources