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Why do cancers have high aerobic glycolysis?
Nature Reviews Cancer, 2004If carcinogenesis occurs by somatic evolution, then common components of the cancer phenotype result from active selection and must, therefore, confer a significant growth advantage. A near-universal property of primary and metastatic cancers is upregulation of glycolysis, resulting in increased glucose consumption, which can be observed with clinical ...
Robert A, Gatenby, Robert J, Gillies
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Aerobic Inhibition of Glycolysis
Nature, 1958DURING investigations on the synthesis of sucrose from glucose-1-phosphate and fructose by pea seed extracts it was observed that a glycolytic system was operating in the enzymic digests1,2. The pea extract had been partially purified by precipitation with ammonium sulphate (80 per cent saturation) and dialysis against phosphate buffer at pH. 7.0.
J F, TURNER, L W, MAPSON
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Ubiquitination regulation of aerobic glycolysis in cancer
Life Sciences, 2022Aerobic glycolysis, or the Warburg effect, is regarded as a critical part of metabolic reprogramming and plays a crucial role in the occurrence and development of tumours. Ubiquitination and deubiquitination, essential post-translational modifications, have attracted increasing attention with regards to the regulation of metabolic reprogramming in ...
Yao, Xie +5 more
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AEROBIC GLYCOLYSIS OF X-IRRADIATED THYMOCYTES
Canadian Journal of Biochemistry and Physiology, 1963The aerobic lactate production of rat thymocyte suspensions incubated at 37 °C for 2 hours was doubled following exposure to approximately 70 r X-radiation. Lower doses down to 18 r also produced a significant increase in aerobic lactate production. Increased lactate accumulation following exposure to 1000 r was observed after incubation for as little ...
K, ARAKI, D K, MYERS
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Aerobic glycolysis in the ox cornea
Experimental Eye Research, 1969Measurements of lactate production at steady state in aerobic conditions show conclusively that aerobie glycolysis does take place in the intact corneal epithelium of the ox. An earlier report to the contrary ( de Roetth, 1951 ) is resolved when the original data are reevaluated.
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Emerging roles of aerobic glycolysis in breast cancer
Clinical and Translational Oncology, 2019Altered aerobic glycolysis is a well-recognized characteristic of cancer cell energy metabolism, known as the Warburg effect. Even in the presence of abundant oxygen, a majority of tumor cells produce substantial amounts of energy through a high glycolytic metabolism, and breast cancer (BC) is no exception.
Z. Wu, J. Wu, Q. Zhao, S. Fu, J. Jin
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Effects of quercetin on rat testis aerobic glycolysis
Canadian Journal of Physiology and Pharmacology, 1995Lactate production by testicular fragments and isolated germinal cells at various stages of spermatogenesis was studied in aerobic and anerobic conditions. Several ATPase inhibitors were used to determine the role of ATPase activities in the control of aerobic lactate production.
R, Trejo +2 more
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Aerobic glycolysis: A study of human articular cartilage
Cell Biochemistry and Function, 1987AbstractCartilage generally is one of those tissues that exhibit aerobic glycolysis. In a previous study on rat epiphyseal cartilage it had been suggested that this phenomenon is related to potentially excessive production of pyruvate and acetyl coenzyme A, the latter derived from fatty acid oxidation and inhibiting pyruvate dehydrogenase activity. The
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Foxk1 promotes bone formation through inducing aerobic glycolysis
Cell Death & DifferentiationTranscription factor Foxk1 can regulate cell proliferation, differentiation, metabolism, and promote skeletal muscle regeneration and cardiogenesis. However, the roles of Foxk1 in bone formation is unknown. Here, we found that Foxk1 expression decreased in the bone tissue of aged mice and osteoporosis patients.
Chungeng Liu +7 more
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[Aerobic glycolysis of tumor cells].
Die Naturwissenschaften, 1981A high aerobic glycolysis (aerobic lactate production) is the most significant feature of the energy metabolism of rapidly growing tumor cells. Several mechanisms, which may be different in different cell lines, seem to be involved in this characteristic of energy metabolism of the tumor cell.
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