Results 61 to 70 of about 68,481 (311)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Surrogate-based evolutionary optimization of aerodynamic performance and emitted sound for an impeller fan

Engineering Applications of Computational Fluid Mechanics
Centrifugal fans are widely used in building ventilation and air-conditioning systems but face increasing demands for higher energy efficiency, improved performance, and lower noise levels.
Hamid Motamedi Zokae, David Moxey, Gavin Tabor   +2 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Efficient aerodynamic shape optimization by using unsupervised manifold learning to filter geometric features

Engineering Applications of Computational Fluid Mechanics
Many aerodynamic shape optimization methods often focus on utilizing the end-to-end relationship between design variables and aerodynamic performance to find the optimal design, while overlooking the exploration of geometric knowledge of the shape itself.
Long Ma, Xiao-Jing Wu, Wei-Wei Zhang
doaj   +1 more source

Aerodynamic optimization of NACA 0012 airfoils with attached Gurney flap in the rarefied gas flow

AIP Advances, 2023
The aerodynamic optimization of a Gurney flap attached to the NACA 0012 airfoil in rarefied gas flow is studied in this study. In order to investigate the effects of Gurney flap geometry (height, mounting angle, and mounting location) and angle of attack
Keren Lin, Songqin Zhang, Chenfan Liu, Haiwei Yang, Bin Zhang   +4 more
doaj   +1 more source

Cluster-based feedback control of turbulent post-stall separated flows

, 2018
We propose a novel model-free self-learning cluster-based control strategy for general nonlinear feedback flow control technique, benchmarked for high-fidelity simulations of post-stall separated flows over an airfoil. The present approach partitions the
Brunton, Steven L., Kaiser, Eurika, Nair, Aditya G., Noack, Bernd R., Taira, Kunihiko, Yeh, Chi-An   +5 more
core   +1 more source

A multifidelity multiobjective optimization framework for high-lift airfoils [PDF]

, 2016
High-lift devices design is a challenging task as it involves highly complex flow features while being critical for the overall performance of the aircraft.
Demange, Jean, Kipouros, Timoleon, Savill, Mark A.   +2 more
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

An optimization procedure of shape and position of the aerodynamic device at the rear side of a semi-trailer truck model

Heliyon
The paper outlines the development and optimization of an aerodynamic device for a semi-trailer truck model to reduce aerodynamic drag force. The optimization procedure involves the selection of a basic aerodynamic device shape, using airfoil profiles ...
Stjepan Galamboš, Nebojša Nikolić, Goran Vorotović, Boris Stojić, Jovan Dorić, Dalibor Feher   +5 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source