Results 61 to 70 of about 67,904 (291)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Surrogate-based evolutionary optimization of aerodynamic performance and emitted sound for an impeller fan

Engineering Applications of Computational Fluid Mechanics
Centrifugal fans are widely used in building ventilation and air-conditioning systems but face increasing demands for higher energy efficiency, improved performance, and lower noise levels.
Hamid Motamedi Zokae, David Moxey, Gavin Tabor   +2 more
doaj   +1 more source

Aerodynamic optimization of NACA 0012 airfoils with attached Gurney flap in the rarefied gas flow

AIP Advances, 2023
The aerodynamic optimization of a Gurney flap attached to the NACA 0012 airfoil in rarefied gas flow is studied in this study. In order to investigate the effects of Gurney flap geometry (height, mounting angle, and mounting location) and angle of attack
Keren Lin, Songqin Zhang, Chenfan Liu, Haiwei Yang, Bin Zhang   +4 more
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Stealth Unmanned Aerial Vehicle Penetration Efficiency Optimization Based on Radar Detection Probability Model

Aerospace
Aerodynamic/stealth optimization is a key issue during the design of a stealth UAV. Balancing the weight of different incident angles of the RCS and combining stealth characteristics with aerodynamic characteristics are hotspots of aerodynamic/stealth ...
Chengen Yuan, Dongli Ma, Yuhong Jia, Liang Zhang   +3 more
doaj   +1 more source

Application of Nontraditional Optimization Techniques for Airfoil Shape Optimization

Modelling and Simulation in Engineering, 2012
The method of optimization algorithms is one of the most important parameters which will strongly influence the fidelity of the solution during an aerodynamic shape optimization problem.
R. Mukesh, K. Lingadurai, U. Selvakumar
doaj   +1 more source

Geometry Design Optimization of a Wind Turbine Blade Considering Effects on Aerodynamic Performance by Linearization

Energies, 2020
For a wind turbine to extract as much energy as possible from the wind, blade geometry optimization to maximize the aerodynamic performance is important.
Kyoungboo Yang
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Efficient aerodynamic shape optimization by using unsupervised manifold learning to filter geometric features

Engineering Applications of Computational Fluid Mechanics
Many aerodynamic shape optimization methods often focus on utilizing the end-to-end relationship between design variables and aerodynamic performance to find the optimal design, while overlooking the exploration of geometric knowledge of the shape itself.
Long Ma, Xiao-Jing Wu, Wei-Wei Zhang
doaj   +1 more source

A Study of Multi-Objective Aerodynamic Optimization Design for Variable Camber Airfoils and High Lift Devices [PDF]

Xibei Gongye Daxue Xuebao, 2018
Aiming at the synthetical optimization of the aerodynamic performance between the low-speed condition of two-dimensional high lift devices during take-off and landing phase and the high-speed condition of variable camber airfoil during cruise phase, an ...

doaj   +1 more source