Results 101 to 110 of about 147,005 (295)

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

The aerodynamic design of a compressor-drive turbine for use in a 75 kw automotive engine [PDF]

The design of a single stage axial-flow turbine with a tip diameter of 11.15 cm is presented. The design specifications are given, and the aerodynamic design procedure is described.
Mclallin, K. L., Roelke, R. J.
core   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

Experimental Investigation of Aerodynamic Interaction in Non-Parallel Tandem Dual-Rotor Systems for Tiltrotor UAV

Drones
The distributed electric tilt-rotor Unmanned Aerial Vehicle (UAV) combines the vertical take-off and landing (VTOL) capability of helicopters with the high-speed cruise performance of fixed-wing aircraft, offering a transformative solution for Urban Air ...
He Zhu, Yuhao Du, Hong Nie, Zhiyang Xin, Xi Geng   +4 more
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

The dynamic behavior of rotor entry vehicle configurations. Volume 2 - Digital computer program manual [PDF]

Digital computer program for evaluating aerodynamic performance of rotor in flight in proximity to reentry ...
Giansante, N., Metzger, R. F.
core   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

Efficient Adaptive Robust Aerodynamic Design Optimization Considering Uncertain Inflow Variations for a Diffusion Airfoil Across All Operating Incidences

Aerospace
The random fluctuations in inlet flow represent a common uncertainty in aero-engine compressors, necessitating the control of its effects through blade optimization design.
Zhengtao Guo, Lei Bao, Chaolong Li, Xianzhong Gao, Wuli Chu   +4 more
doaj   +1 more source

An effective approach for robust design optimization of wind turbine airfoils with random aerodynamic variables

Advances in Mechanical Engineering, 2019
The robust design optimization of an airfoil needs to continuously realize the probability-based aerodynamic simulation for various combinations of geometry and wind climate parameters.
Xufang Zhang, Zhenguang Wu, Wei He
doaj   +1 more source

Methodology for sensitivity analysis, approximate analysis, and design optimization in CFD for multidisciplinary applications [PDF]

Fundamental equations of aerodynamic sensitivity analysis and approximate analysis for the two dimensional thin layer Navier-Stokes equations are reviewed, and special boundary condition considerations necessary to apply these equations to isolated ...
Hou, Gene W., Taylor, Arthur C., III
core   +1 more source