Results 71 to 80 of about 20,831 (218)

A phase 1 evaluation of inhaled oxytocin: Physiologically‐based pharmacokinetic model informed dosing of a novel heat‐stable oxytocin delivery system

British Journal of Clinical Pharmacology, EarlyView.
Aim To develop and validate a physiologically‐based pharmacokinetic (PBPK) model enabling inhaled oxytocin dose selection for clinical evaluation. Subsequently, to conduct a phase 1 study investigating the pharmacokinetics and safety of selected doses of an optimized inhaled oxytocin product in healthy, non‐pregnant female participants.
Pete Lambert, Carl M. J. Kirkpatrick, Rory Marriott, Siladitya Ray Chaudhuri, David Polidori, Bart Remmerie, Michelle P. McIntosh   +6 more
wiley   +1 more source

Stratospheric Polar Vortex Exerts Different Controls on the Transport of Tropical and Mid‐Latitude Volcanic Aerosols

Geophysical Research Letters
Moderate volcanic eruptions and extreme wildfires in recent two decades have persistently perturbed global stratospheric aerosol loadings. Based on satellite observations and climate model simulations, we find that these events contribute to ∼67% of ...
Yifeng Peng, Wenshou Tian, Cheng‐Cheng Liu, Pengfei Yu   +3 more
doaj   +1 more source

Status and future of recombinant adeno‐associated virus vector manufacturing

Biotechnology Progress, EarlyView.
Abstract Sixty years of adeno‐associated virus (AAV) research illustrates a trajectory marked by basic science exploration, iterative innovation, persistent challenges, a number of clinical setbacks, as well as commercial therapeutic triumphs. This continual evolution has led to recombinant AAV (rAAV) becoming a cornerstone of modern gene therapy ...
Frank Agbogbo, David Dismuke
wiley   +1 more source

Perovskite Photodetectors at the Intelligence Frontier: From Tunable Materials to Adaptive Optoelectronic Systems

Carbon Energy, EarlyView.
This comprehensive review presents a progressive roadmap for perovskite vision detectors. Centered on perovskite‐based artificial perception, the graphic illustrates a systematic evolution: starting with fundamental material engineering and device architectures, advancing toward complex functional strategies such as flexible neuromorphic imaging ...
Chenglong Li, Wei Qu, Deepak Kumar, Naini Jain, Nur Wardina Syahirah binti Mohamad Fadil, Nur Najiha binti Ahmad Rasid, Emannuel Kymakis, Maria Vasilopoulou, Chunxiong Bao, Feng Gao, Peng Gao, Sanjeev Kumar Sharma, Mohammad Khaja Nazeeruddin, Abd. Rashid bin Mohd Yusoff, Haotong Wei   +14 more
wiley   +1 more source

A Date Under the Stars? Maybe Not with Aerosol Injection

Eos, 2016
Injecting aerosols into the atmosphere on purpose could help cool Earth, but new research shows that it could also make the night sky brighter and negatively affect human health.
openaire   +1 more source

Fungal Antimicrobial Resistance: Mechanisms, Drivers, and Global Clinical Burden

ChemFoodChem, EarlyView.
ABSTRACT Fungal antimicrobial resistance (AMR) is a growing concern for world health caused by an increase in multidrug‐resistant infections, an increase in environmental reservoirs, and the ineffectiveness of current antifungal treatments. Fungal infections continue to be largely excluded from AMR initiatives while causing over 1.6 million deaths ...
Bikash Baral
wiley   +1 more source

Solar Fuels Via Methane Valorization: Thermochemical Pathways, Unified Metrics, and Techno‐Economic Perspectives

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
A first‐of‐its‐kind review benchmarks three solar methane valorization pathways with unified performance metrics for clean fuel production. Meeting global climate targets and sustainable energy demands requires carbon‐neutral fuels and innovative conversion pathways.
Muhammad Abdulmoez, Amjad Othman, Majid Linjawi, Amro Al‐Qutub   +3 more
wiley   +1 more source

One‐Step Synthesis of Si–Graphene Heterostructures via in‐Flight Gas‐Phase Mixing for High‐Capacity Silicon‐Rich Anodes

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
A one‐step gas‐phase synthesis directly assembles amorphous Si nanoparticles with few‐layer graphene heterostructures via in‐flight mixing. Compositions with only 15 wt.% FLG deliver ~2800 mAh g−1 (Si + FLG) at 0.05 C and retain ~1400 mAh g−1 after 100 cycles at a high cycling rate of 1 C, enabled by a percolated, strain‐buffering graphene network that
Muhammad Ali, Mukarram Ali, Yasaman Jarrahizadeh, Axel Lorke, Michael A. Pope, Hartmut Wiggers   +5 more
wiley   +1 more source

Decadal Changes of UV Aerosol Optical Depth in Hobart, Australia Measured With a Brewer MKIII: Relationship to Bushfire Events and Climate Indices

International Journal of Climatology, EarlyView.
Monthly average aerosol optical depth at 320 nm obtained with a Brewer MKIII spectrophotometer for Hobart, Australia (42.8806° S, 147.3250° E) over a 21‐year period. There is a linear trend of 15.4% per decade. There are 9 months when the average aerosol optical depth exceeds twice the monthly standard deviation.
Manuel Nuñez, Antonio Serrano, Peter Love, Nels Larson   +3 more
wiley   +1 more source

Kinetic Study on the Reaction of Phenylperoxy Radicals With Nitric Oxide

International Journal of Chemical Kinetics, EarlyView.
ABSTRACT Cavity ring‐down spectroscopy (CRDS) and quantum cascade laser absorption spectroscopy (QCLAS), in conjunction with pulsed laser photolysis, were employed to investigate the reaction between phenylperoxy radicals (C6H5O2) and nitric oxide (NO) at a temperature of 296 ± 4 K. The experiment was carried out under N2 as bath gas.
Maya Matsushita, Michiya Fujita, Kenichi Tonokura   +2 more
wiley   +1 more source