Identification of genes transcriptionally responsive to the loss of MLL fusions in MLL-rearranged acute lymphoblastic leukemia. [PDF]
PLoS ONE, 2015 MLL-rearranged acute lymphoblastic leukemia (ALL) in infants (
Marieke H van der Linden +10 more
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Cardio-renal protection and mechanisms of the antihypertensive activity of Alcalase-derived moth bean hydrolysate in DOCA-salt induced hypertensive Wistar rats [PDF]
Scientific ReportsHypertension remains a major global health concern, often leading to severe cardiovascular and renal complications. In this study, we investigated the antihypertensive and cardiorenal protective effects of AF4, a bioactive Alcalase derived peptide ...
Nancy Goyal +3 more
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AF4-to-SAXS: expanded characterization of nanoparticles and proteins at the P12 BioSAXS beamline [PDF]
Journal of Synchrotron RadiationBiological small-angle X-ray scattering (SAXS) is a versatile and powerful technique for investigating the structural and biophysical properties of biologically and pharmaceutically relevant macromolecules and nanoparticles. SAXS offers detailed insights
Stefano Da Vela +12 more
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MLL-AF4 upregulates 5-lipoxygenase expression in t(4;11) leukemia cells via the ALOX5 core promoter [PDF]
Frontiers in Pharmacology5-Lipoxygenase (5-LO), encoded by the gene ALOX5, is implicated in several pathologies. As key enzyme in leukotriene biosynthesis, 5-LO plays a central role in inflammatory diseases, but the 5-LO pathway has also been linked to development of certain ...
Marius Hyprath +4 more
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Clinical characteristics and prognostic analysis of different fusion gene abnormalities in childhood acute lymphoblastic leukaemia [PDF]
Frontiers in OncologyObjectiveThis study aimed to analyze the clinical features and prognostic significance of different fusion gene subtypes in pediatric patients with acute lymphoblastic leukaemia (ALL).MethodsClinical data from 132 childhood patients with ALL diagnosed ...
Rui Fan +9 more
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Bacillus-derived lipopeptides inhibit and eradicate Candida tropicalis Biofilms: An in vitro exploration [PDF]
BiofilmCandida tropicalis is a WHO-prioritised opportunistic fungal pathogen capable of causing superficial-to-systemic fungal infections and forming biofilms on both biotic and abiotic surfaces, such as tissues and medical implants.
Madhuri Madduri +2 more
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Venetoclax in combination with chidamide and azacitidine for the treatment of relapsed/refractory B-cell acute lymphoblastic leukemia with the MLL-AF4 gene: a case report and literature review [PDF]
Frontiers in ImmunologyB-cell acute lymphoblastic leukemia (B-ALL) with the MLL-AF4 fusion gene has a poor prognosis, and the mortality rate exceeds 90%, particularly in cases of extramedullary relapse (EMR).
Xuelian Jin, Zhigang Liu, Yu Wu, Jie Ji
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Stability of Am(Ⅲ) Colloid and Its Adsorption Behavior on Bentonite Colloids
He huaxue yu fangshe huaxue, 2022 The formation of Am(Ⅲ) colloid and its adsorption behaviors on bentonite colloid were investigated in Beishan 03 groundwater. A series of influencing factors, such as, pH, CO2 concentration in gas atmosphere, ionic strength and temperature, on colloidal ...
LIU Chen +6 more
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Pharmaceuticals, 2022 RNA molecules provide promising new possibilities for the prevention and treatment of viral infections and diseases. The rapid development of RNA biology and medicine requires advanced methods for the purification of RNA molecules, which allow fast and ...
Alesia A. Levanova +5 more
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RNA-binding proteins of KHDRBS and IGF2BP families control the oncogenic activity of MLL-AF4
Nature Communications, 2022 The establishment of a mouse model of MLL-AF4-induced leukaemia is a challenge as the introduction of fusion gene of human MLL-AF4 does not cause leukaemia in mice.
Hiroshi Okuda +7 more
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