Results 11 to 20 of about 20,026 (197)

Enhanced hemato-endothelial specification during human embryonic differentiation through developmental cooperation between AF4-MLL and MLL-AF4 fusions

Haematologica, 2019
The t(4;11)(q21;q23) translocation is associated with high-risk infant pro-B-cell acute lymphoblastic leukemia and arises prenatally during embryonic/fetal hematopoiesis.
Clara Bueno, Fernando J Calero-Nieto, Xiaonan Wang, Rafael Valdés-Mas, Francisco Gutiérrez-Agüera, Heleia Roca-Ho, Veronica Ayllon, Pedro J Real, David Arambilet, Lluis Espinosa, Raul Torres-Ruiz, Antonio Agraz-Doblas, Ignacio Varela, Jasper de Boer, Anna Bigas, Bertie Gottgens, Rolf Marschalek, Pablo Menendez   +17 more
doaj   +16 more sources

t(4;11) leukemias display addiction to MLL-AF4 but not to AF4-MLL [PDF]

Leukemia Research, 2011
The most frequent MLL-gene rearrangement found in leukemia is a reciprocal translocation with AF4 on chromosome 4 resulting in the formation of the MLL-AF4 and the AF4-MLL fusion genes. The oncogenic role of MLL-AF4 is documented but the significance of the reciprocal product - AF4-MLL in leukemia is less clear.
Ashish R, Kumar, Qing, Yao, Quanzhi, Li, Thien A, Sam, John H, Kersey   +4 more
openaire   +2 more sources

MLL-AF4 and a murinized pSer-variant thereof are turning on the nucleolar stress pathway

Cell & Bioscience, 2022
Background Recent pathomolecular studies on the MLL-AF4 fusion protein revealed that the murinized version of MLL-AF4, the MLL-Af4 fusion protein, was able to induce leukemia when expressed in murine or human hematopoietic stem/progenitor cells (Lin et ...
Anna Lena Siemund, Thomas Hanewald, Eric Kowarz, Rolf Marschalek   +3 more
doaj   +1 more source

The elucidation of the multimodal action of the investigational anti-Candida lipopeptide (AF4) lead from Bacillus subtilis

Frontiers in Molecular Biosciences, 2023
Background:Candida species are the main etiological agents for candidiasis, and Candida albicans are the most common infectious species. Candida species’ growing resistance to conventional therapies necessitates more research into novel antifungal agents.
Swetha Ramesh, Utpal Roy, Subhashis Roy
doaj   +1 more source

Neuroprotective and anti-inflammatory effects of the flavonoid-enriched fraction AF4 in a mouse model of hypoxic-ischemic brain injury. [PDF]

PLoS ONE, 2012
We report here neuroprotective and anti-inflammatory effects of a flavonoid-enriched fraction isolated from the peel of Northern Spy apples (AF4) in a mouse of model of hypoxic-ischemic (HI) brain damage.
Paul G W Keddy, Kate Dunlop, Jordan Warford, Michel L Samson, Quinton R D Jones, H P Vasantha Rupasinghe, George S Robertson   +6 more
doaj   +1 more source

The Power of Field-Flow Fractionation in Characterization of Nanoparticles in Drug Delivery

Molecules, 2023
Asymmetric-flow field-flow fractionation (AF4) is a gentle, flexible, and powerful separation technique that is widely utilized for fractionating nanometer-sized analytes, which extend to many emerging nanocarriers for drug delivery, including lipid ...
Juan Bian, Nemal Gobalasingham, Anatolii Purchel, Jessica Lin   +3 more
doaj   +1 more source

Asymmetrical Flow Field-Flow Fractionation Coupled to ICP-MS for Characterization of Trace Metal Species in the Environment from Macromolecular to Nano-Assemblage Forms: Current Challenges for Quantification

CHIMIA, 2022
Asymmetrical flow field-flow fractionation (AF4) is a powerful technique employed for the separation of macromolecules, nanoparticles, and their assemblages according to their hydrodynamic behavior.
Isabelle A. M. Worms, Vera I. Slaveykova
doaj   +1 more source

Interaction of AF4 wild-type and AF4·MLL fusion protein with SIAH proteins: indication for t(4;11) pathobiology? [PDF]

Oncogene, 2004
The human AF4 (ALL-1 fused gene on chromosome 4) gene (4q11) is recurrently involved in reciprocal translocations to the MLL (mixed lineage leukemia) gene (11q23), correlated with high-risk acute lymphoblastic leukemia (ALL) in infants and early childhood. The t(4;11) translocation is one of the most frequent MLL translocations known today. In general,
Adelheid, Bursen, Sven, Moritz, Anne, Gaussmann, Sören, Moritz, Theo, Dingermann, Rolf, Marschalek   +5 more
openaire   +3 more sources

Research on Multi-Energy Coordinated Intelligent Management Technology of Urban Power Grid Under the Environment of Energy Internet

Applied Sciences, 2019
Integrated energy systems (IES) are an important physical carrier of the energy Internet, which undertakes the tasks of energy conversion, distribution, and storage of electricity, heat and cold.
Xin Wang, Xiangyu Kong, Zhijun E, Fangyuan Sun, Changzhi Zhang   +4 more
doaj   +1 more source

Lattice distortions in a sawtooth chain with Heisenberg and Ising bonds [PDF]

, 2010
An exactly solvable model of the sawtooth chain with Ising and Heisenberg bonds and with coupling to lattice distortion for Heisenberg bonds is considered in the magnetic field.
A. Honecker, A. Klümper, A. Klümper, C. Kittel, C. Trippe, D. Antonosyan, D. Sen, D.C. Cabra, E. Aydiner, E. Aydiner, F. Litaiff, G.C. Lau, J. Richter, J. Richter, J. Richter, J. Schulenburg, J. Strečka, J. Strečka, J.S. Valverde, K. Hida, K. Penc, L. Čanová, M. Oshikawa, M.S.S. Pereira, M.S.S. Pereira, O. Derzhko, O. Derzhko, O. Le Bacq, S. Bellucci, S. Bissola, S. Miyahara, S.A. Blundell, T. Nakamura, T. Nakamura, T. Vekua, V. Ohanyan, V. Ohanyan, V. Ohanyan, V. Ohanyan   +38 more
core   +2 more sources