Results 31 to 40 of about 20,026 (197)

Frecuencia de los genes de fusión BCR-ABL1, E2A-PBX1, MLL-AF4, y TEL-AML1 con leucemia linfoblástica aguda de células B

Revista Peruana de Ciencias de la Salud, 2023
Objetivo. Describir la frecuencia de los genes de fusión BCR-ABL1, E2A-PBX1, MLL-AF4, y TEL-AML1 en pacientes con leucemia linfoblástica aguda de células B en el Instituto Nacional de Salud del Niño de San Borja, Lima (Perú). Métodos.
Francisco Sánchez-Pinto, Gioconda Manassero, Mónica Carola Correa Guerrero, Guillermo Frank Romero Guerra, Julissa Fuentes Vera   +4 more
doaj   +1 more source

MLL-AF4 Spreading Identifies Binding Sites that Are Distinct from Super-Enhancers and that Govern Sensitivity to DOT1L Inhibition in Leukemia

Cell Reports, 2017
Summary: Understanding the underlying molecular mechanisms of defined cancers is crucial for effective personalized therapies. Translocations of the mixed-lineage leukemia (MLL) gene produce fusion proteins such as MLL-AF4 that disrupt epigenetic ...
Jon Kerry, Laura Godfrey, Emmanouela Repapi, Marta Tapia, Neil P. Blackledge, Helen Ma, Erica Ballabio, Sorcha O’Byrne, Frida Ponthan, Olaf Heidenreich, Anindita Roy, Irene Roberts, Marina Konopleva, Robert J. Klose, Huimin Geng, Thomas A. Milne   +15 more
doaj   +1 more source

The human leukemic oncogene MLL-AF4 promotes hyperplastic growth of hematopoietic tissues in Drosophila larvae

iScience, 2023
Summary: MLL-rearranged (MLL-r) leukemias are among the leukemic subtypes with poorest survival, and treatment options have barely improved over the last decades.
Julie A. Johannessen, Miriam Formica, Aina Louise C. Haukeland, Nora Rojahn Bråthen, Amani Al Outa, Miriam Aarsund, Marc Therrien, Jorrit M. Enserink, Helene Knævelsrud   +8 more
doaj   +1 more source

Uncertainties of size measurements in electron microscopy characterization of nanomaterials in foods [PDF]

, 2015
Electron microscopy is a recognized standard tool for nanomaterial characterization, and recommended by the European Food Safety Authority for the size measurement of nanomaterials in food.
Boxall, A. B. A., Chaudhry, Q., Dudkiewicz, A., Hofmann, P., Linsinger, T. P. J., Molhave, K., Tiede, K.   +6 more
core   +1 more source

Overexpression of the catalytically impaired Taspase1 T234V or Taspase1 D233A variants does not have a dominant negative effect in T(4;11) leukemia cells. [PDF]

PLoS ONE, 2012
BACKGROUND: The chromosomal translocation t(4;11)(q21;q23) is associated with high-risk acute lymphoblastic leukemia of infants. The resulting AF4•MLL oncoprotein becomes activated by Taspase1 hydrolysis and is considered to promote oncogenic ...
Carolin Bier, Rouven Hecht, Lena Kunst, Sabine Scheiding, Désirée Wünsch, Dorothée Goesswein, Günter Schneider, Oliver H Krämer, Shirley K Knauer, Roland H Stauber   +9 more
doaj   +1 more source

circRNA circAF4 functions as an oncogene to regulate MLL-AF4 fusion protein expression and inhibit MLL leukemia progression

Journal of Hematology & Oncology, 2019
Background Circular RNAs (circRNAs) represent a type of endogenous noncoding RNAs that are generated by back-splicing events and favor repetitive sequences.
Wei Huang, Ke Fang, Tian-Qi Chen, Zhan-Cheng Zeng, Yu-Meng Sun, Cai Han, Lin-Yu Sun, Zhen-Hua Chen, Qian-Qian Yang, Qi Pan, Xue-Qun Luo, Wen-Tao Wang, Yue-Qin Chen   +12 more
doaj   +1 more source

Quality control and purification of ready-to-use conjugated gold nanoparticles to ensure effectiveness in biosensing

Frontiers in Sensors, 2022
Introduction: Gold nanoparticles (AuNPs) and their conjugates are used for many applications in the field of sensors. Literature lacks procedures able to separate, purify and characterize these species in native conditions without altering them while ...
Junjie Wang, Stefano Giordani, Valentina Marassi, Valentina Marassi, Barbara Roda, Barbara Roda, Pierluigi Reschiglian, Pierluigi Reschiglian, Andrea Zattoni, Andrea Zattoni   +9 more
doaj   +1 more source

Infant acute leukemia with lineage switch at relapse expressing a novel t(4;11)(q21;q23) MLL-AF4 fusion transcript

Romanian Journal of Laboratory Medicine, 2013
Introducere. Pacienţii cu leucemie acuta limfoblastică (LAL) neonatală prezintă în mod frecvent, o tran- slocaţie particulară, t(4;ll)(q21;q23), care duce la fuziunea genei MLL (mixed lineage leukemia) de pe cromo- zomul 11 cu gena AF4 de pe cromozomul 4.
Ivanov Iuliu C., Jitam Daniela, Grigore Georgiana E., Zlei Mihaela, Ivanov Anca V., Dumitraş Silvia, Carasevici Eugen, Miron Ingritli C.   +7 more
doaj   +1 more source

Detecting Error-Related Negativity for Interaction Design [PDF]

, 2012
This paper examines the ability to detect a characteristic brain potential called the Error-Related Negativity (ERN) using off-the-shelf headsets and explores its applicability to HCI.
Subramanian, S, Vi, C.T
core   +2 more sources

Unraveling the Activation Mechanism of Taspase1 which Controls the Oncogenic AF4–MLL Fusion Protein

EBioMedicine, 2015
We have recently demonstrated that Taspase1-mediated cleavage of the AF4–MLL oncoprotein results in the formation of a stable multiprotein complex which forms the key event for the onset of acute proB leukemia in mice.
Samaneh Sabiani, Tim Geppert, Christian Engelbrecht, Eric Kowarz, Gisbert Schneider, Rolf Marschalek   +5 more
doaj   +1 more source