Aging and Cancer, EarlyView.Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu +8 more
wiley +1 more source
Vitamin B12 and Affective Disorders: A Focus on the Gut-Brain Axis. [PDF]
Alpha PsychiatryXu C +5 more
europepmc +1 more source
Aging Is a Key Driver for Adult Acute Myeloid Leukemia
Aging and Cancer, EarlyView.Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley +1 more source
0049 The Role Of Environmental Light Exposure And Circadian Phase In Seasonal Affective Disorder [PDF]
, 2018 Chris Dupont +5 more
openalex +1 more source
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Case Report: Right-sided vagus nerve stimulation for treatment-resistant affective disorders with complex cardiac comorbidity. [PDF]
Front PsychiatryLicht C, Landgrebe M, Pieper T.
europepmc +1 more source
Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham +7 more
wiley +1 more source
Probiotics as Modulators of Adult Neurogenesis and Synaptic Plasticity: New Perspectives in the Pathophysiology and Treatment of Affective Disorders. [PDF]
BiomedicinesRosas-Sánchez GU +8 more
europepmc +1 more source
THE RELATIONSHIP ALEXITYMIA, POSITIVE AFFECT AND NEGATIVE AFFECT WITH THE OBSESSIVE - COMPULSIVE DISORDER SYNDROME [PDF]
, 2013 Jahangir Karami +2 more
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