Results 191 to 200 of about 245,119 (310)

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

Aspirin and atorvastatin augmentation treatment in patients with major affective disorders and inflammatory dysregulation: a 12-week randomised Placebo-controlled study. [PDF]

Acta Neuropsychiatr
Bai YM, Hsu JW, Liou YJ, Chen MH.
europepmc   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

The relationship between heart rate variability and affective disorders: associations with symptomatic improvement and therapeutic alliance. [PDF]

BMC Psychol
Gonçalves AF, Ribeiro E, Sampaio A, Couto-Pereira NS, Moreira P, Coutinho JF.   +5 more
europepmc   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

National mortality trends in mood affective disorders and hypertensive/ischemic heart diseases in the United States, 1999 to 2020: a CDC WONDER analysis. [PDF]

Proc (Bayl Univ Med Cent)
Dawood MH, Kumar R, Aman MS, Qadri SMH, Qadri L.   +4 more
europepmc   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Trajectories of affective disorders: neurobiological mechanisms during symptom change. [PDF]

Nervenarzt
Ebner-Priemer UW, Alferink J, Bauer M, Dannlowski U, Falkenberg I, Forstner AJ, Hahn T, Junghöfer M, Kircher T, Klotz L, Martini J, Mennigen E, Nenadić I, Pariante C, Pfennig A, Ziller M, Meinert S.   +16 more
europepmc   +1 more source

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source

The association between white matter hyperintensities and suicide attempts in affective disorders: a systematic review and meta-analysis. [PDF]

Transl Psychiatry
Torino G, Maggioni E, Lengvenyte A, Brambilla P, Delvecchio G.   +4 more
europepmc   +1 more source