Results 81 to 90 of about 7,446,825 (333)

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Effective Discussions of Affective Cases: A Survey of Attenders of the Mood Disorders Grand Rounds

BJPsych Open
Aims: Specialist mood disorder services in the UK are diverse in structure and spread over different clinical-academic centres in the UK. Relationships between these centres are strong but often based on academic projects, with limited opportunities for ...
Joseph Thorne, Tiago Costa, Michael Browning, Stuart Watson   +3 more
doaj   +1 more source

A latent class analysis of parental bipolar disorder: examining associations with offspring psychopathology [PDF]

, 2015
Bipolar disorder (BD) is highly heterogeneous, and course variations are associated with patient outcomes. This diagnostic complexity challenges identification of patients in greatest need of intervention.
Freed, Rachel D., Henin, Aude, Nierenberg, Andrew A., Otto, Michael W., Tompson, Martha C.   +4 more
core   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Subdividing the functional psychoses: a family hereditary approach [PDF]

, 2017
Family genetic data, based on standardized and independent diagnostic procedures of index and secondary cases, confirmed the dichotomy between schizophrenias and affective disorders.
Scharfetter, Christian
core  

Family coordination in families who have a child with autism spectrum disorder [PDF]

, 2018
Little is known about the interactions of families where there is a child with autism spectrum disorder (ASD). The present study applies the Lausanne Trilogue Play (LTP) to explore both its applicability to this population as well as to assess resources ...
A Lonigro, AA Hollingshead, AB Kelly, AH Rutgers, AS Carter, C Carneiro, C Kasari, C Lord, C Lord, C Trevarthen, CD Hoffman, CG Pottie, Christian Veronesi, D Oppenheim, D Oppenheim, D Steijn van, Diane Philipp, DN Stern, E Fivaz Depeursinge, E Fivaz Depeursinge, E Fivaz Depeursinge, E Sucksmith, EM Dykens, F Laghi, Fiorenzo Laghi, G Montes, G Vivanti, GM Griffith, I Marcu, II Fishman, J Cohen, J Duvekot, J McHale, J McHale, JL Taylor, JS Karst, L Adamson, L Oberman, Laura Vismara, LC Wynne, LE Libero, LE Marsh, M Ainsworth, M Losh, M Malagoli Togliatti, MH IJzendoorn Van, N Favez, N Favez, NO Davis, NV Ekas, P Fonagy, P Fonagy, PA Rao, PJ Curran, R Giallo, R Hoefman, R Phelps, RP Hastings, S Baron-Cohen, S Minuchin, S Rogers, Silvia Mazzoni, SSF Gau, T Cadman, U Frith   +64 more
core   +1 more source

Vitamin D in anxiety and affective disorders.

Physiological Research, 2015
Reduced levels of vitamin or its metabolites have been reported in various psychiatric disorders. Insufficient levels of vitamin D in depressive patients have been confirmed by many authors, but there have been conflicting results in subjects with ...
M. Bičı́ková, M. Dušková, J. Vítků, B. Kalvachová, D. Řípová, P. Mohr, Ľ. Stárka   +6 more
semanticscholar   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Trends in pharmacological prescriptions and polypharmacy for personality disorders: a 10-year cross-sectional analysis of naturalistic data

BMC Psychiatry
Introduction The purpose of this study was to examine trends in prescribing practices for individuals diagnosed with personality disorders (PD) over a 10-year period in a major metropolitan area in Sweden.
Flavio Di Leone, Steinn Steingrimsson, Hanne Krage Carlsen, Sophie I. Liljedahl, Peter Sand   +4 more
doaj   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source