Results 131 to 140 of about 425,521 (287)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

POSITIVE ATTITUDES AND NEGATIVE OF THE STUDENTS IN THE LEARNING OF MATHEMATICS, ITS IMPACT ON THE REPROACH AND TERMINAL EFFICIENCY

Ra Ximhai, 2014
The present investigation aimed to problematize "the positive and negative attitudes of students in learning mathematics, their impact on disapproval index and terminal efficiency." It was held in the Academic Unit "Rubén Jaramillo" of the Autonomous ...
Ladislao Romero–Bojórquez, Alejandra Utrilla–Quiroz, Victor Manuel Utrilla–Quiroz   +2 more
doaj  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Beyond Language Gains: A Meta-Analysis of Non-Linguistic Outcomes of ChatGPT-Integrated English Instruction in South Korea

Education Sciences
This meta-analysis investigates the outcomes associated with ChatGPT-integrated English instruction on non-linguistic outcomes in South Korea. Following the PRISMA 2020 guidelines, 22 experimental studies (k = 26, N = 1303) were synthesized using a ...
Je-Young Lee
doaj   +1 more source

About relationships in the affect domain

, 2015
During the last decade, learning/teaching environment has assumed an important role in affect research due to the socio-constructivist account of learning/teaching mathematics. Despite this, the concept of interperson-al relationship, which is an important variable of the environment, has not yet been considered explicitly in affect research. The first
MOSCUCCI, MANUELA, Bibbò, Cecilia
openaire   +2 more sources

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Analysis of the online microteaching practice of undergraduate physical education students

Cakrawala Pendidikan: Jurnal Ilmiah Pendidikan
Microteaching aims to ensure that students, as prospective educators, deserve to experience real teaching-learning situations. However, in light of recent advancements in educational technology and the increasing integration of online learning, it has ...
Hermawan Pamot Raharjo, Donny Wira Yudha Kusuma, Ani Mazlina Dewi Mohamed, Tandiyo Rahayu, Mohamad Annas, Ranu Baskora Aji Putra, Agus Widodo Suripto, Wahyu Ragil Kurniawan   +7 more
doaj   +1 more source

Expressing social attitudes in virtual agents for social training games

, 2014
The use of virtual agents in social coaching has increased rapidly in the last decade. In order to train the user in different situations than can occur in real life, the virtual agent should be able to express different social attitudes.
Chollet, Mathieu, Jones, Hazaël, Ochs, Magalie, Pelachaud, Catherine, Sabouret, Nicolas   +4 more
core  

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source