Results 111 to 120 of about 425,521 (287)

Infield education: Enhancing adult learners’ affective domain for transformative learning endorsement

open access: yesCogent Education, 2019
The most influential element in any educational system is to develop high- quality learners to effectively participate in their community. The body of research ascertains that Experiential Learning (EL) develops the learners’ transferrable skills such as
Hany Zaky
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

Differences in Affective Domain Development Music Learning between Indonesia, The Netherlands, and France

open access: yesHarmonia: Journal of Arts Research and Education
The ‘affective domain’ supports students’ moral development, shaping their character. The research aims to investigate the music learning process in Indonesia, the Netherlands, and France and determine its contribution to the affective domain.
Kun Setyaning Astuti   +3 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Reflections on Interdisciplanary Communications - Metaperspectives; Exploring the Affective Domain [PDF]

open access: yesJournal of Systemics, Cybernetics and Informatics, 2019
Innovation and/or research performed by Inter, Cross, and Trans disciplinary teams requires individuals to develop an understanding of how their discipline relates to other disciplines.
Bruce Peoples
doaj  

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

open access: yesMolecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli   +7 more
wiley   +1 more source

IMPLEMENTASI PENGGUNAAN MEDIA VIDEO DALAM MODEL PEMBELAJARAN INQUIRY PADA PEMAHAMAN PROSEDUR KESELAMATAN KERJA PEMBUATAN BOX PADA MATA KULIAH PRAKTEK BENGKEL DAN KESELAMATAN KERJA [PDF]

open access: yes, 2015
Penelitian ini bertujuan untuk mengetahui hasil implementasi penggunaan video pada model pembelajaran inquiry pada pemahaman konsep keselamatan kerja dan bengkel ditinjau dari ranah kognitif, afektif, dan psikomotor.
Kusuma, Indra
core  

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