Results 181 to 190 of about 1,578,929 (319)

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Inverted insulin to C-Peptide ratios in neonatal intensive care: is there something we don't know? [PDF]

Front Pediatr
Chase JG, Shannon HD.
europepmc   +1 more source

HELIN E-Resources Affinity Group minutes for 1/10/2013

, 2013
Minutes of the E-Resources Affinity Group of the HELIN Consortium for January ...
HELIN Consortium. E-Resources Affinity Group
core  

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

GAMT-GINE: A Graph Isomorphism Network Integrating Continuous Spatial Awareness and Multi-Task Learning for Protein-Ligand Binding Affinity Prediction. [PDF]

Int J Mol Sci
Li J, Li H, Wu D, He W, Cao W, Yang H, Hou Z.   +6 more
europepmc   +1 more source

HELIN E-Resources Affinity Group minutes for 1/28/2016

, 2016
Minutes of the E-Resources Affinity Group of the HELIN Consortium for January ...
HELIN Consortium. E-Resources Affinity Group
core  

Ofatumumab in Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease: A Comparison With Rituximab

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the efficacy and safety of ofatumumab in patients with myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), and compare it with rituximab. Methods We conducted a single–center, observational study including 22 MOGAD patients treated with ofatumumab and 21 treated with rituximab.
Yuxin Fan, Lei Zhou, Jingzi ZhangBao, Hongmei Tan, Zhouzhou Wang, Chao Quan   +5 more
wiley   +1 more source

4-Ethyl phenyl sulfate binding to human serum albumin. [PDF]

Protein Sci
Niestanak VD, Zattoni J, McKay RT, Tonelli M, Aminpour M, Unsworth LD.   +5 more
europepmc   +1 more source

HELIN E-Resources Affinity Group Minutes for 3/12/2015

, 2015
Minutes of the E-Resources Affinity Group of the HELIN Consortium for March ...
HELIN Consortium. E-Resources Affinity Group
core  

White Matter Microstructural Abnormalities in Neonatal Onset Genetic Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Recent evidence indicates that epilepsy is associated with abnormal white matter. If seizures alter white matter, then the impact upon network function, epileptogenesis, and cognition could be pronounced in neonates undergoing rapid developmental myelination. Neonates with epilepsy due to nonstructural genetic causes provide a unique
Amanda G. Sandoval Karamian, Tianjia Zhu, Hao Huang, Shavonne L. Massey, Mark P. Fitzgerald, Darshana Parikh, Arastoo Vossough, Ingo Helbig, Nicholas S. Abend   +8 more
wiley   +1 more source