Results 41 to 50 of about 1,074,495 (313)
Delimiting affinity zones as a basis for air pollution mapping in Europe
Environment International, 2013 Affinity zones are defined as areas within which air quality displays consistent behaviour over space and time. Constructed using multivariate statistical techniques and physiographic and landscape variables reflecting underlying sources and spatial ...
Danielle Vienneau, David J. Briggs
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Probing high affinity sequences of DNA aptamer against VEGF165. [PDF]
PLoS ONE, 2012 Vascular endothelial growth factor (VEGF(165)) is a potent angiogenic mitogen commonly overexpressed in cancerous cells. It contains two main binding domains, the receptor-binding domain (RBD) and the heparin-binding domain (HBD). This study attempted to
Harleen Kaur, Lin-Yue Lanry Yung
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FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Analysis of a complete DNA–protein affinity landscape [PDF]
Journal of The Royal Society Interface, 2009 Properties of biological fitness landscapes are of interest to a wide sector of the life sciences, from ecology to genetics to synthetic biology. For biomolecular fitness landscapes, the information we currently possess comes primarily from two sources: sparse samples obtained from directed evolution experiments; and more fine-grained but less ...
Rowe, William +5 more
openaire +2 more sources
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
A mathematical model for germinal centre kinetics and affinity maturation
, 2002 We present a mathematical model which reproduces experimental data on the germinal centre (GC) kinetics of the primed primary immune response and on affinity maturation observed during the reaction.
DAGMAR IBER +6 more
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, 2020 Protein-ligand binding affinity is a key pharmacodynamic endpoint in drug discovery. Sole reliance on experimental design, make, and test cycles is costly and time consuming, providing an opportunity for computational methods to assist.
conor, parks, Zied, Gaieb, Rommie, Amaro
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Frontiers in Molecular Biosciences, 2022 Numerous studies have highlighted the utility of glycan microarray analysis for the elucidation of protein-glycan interactions. However, most current glycan microarray studies analyze glycan binding protein (GBP)-glycan interactions at a single protein ...
Alex D. Ho +6 more
doaj +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Expression analysis of putative high-affinity phosphate transporters in Chinese winter wheats
, 2002 China's soils tend to be phosphate deficient. Application of phosphorus fertilisers to the soil is yield and cost ineffective as much of the phosphate applied is rapidly locked-in and is inaccessible to the crop.
Gordon-Weeks, R. +5 more
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