Results 61 to 70 of about 1,074,495 (313)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Studies and analysis of drug-target interactions by affinity chromatography and related techniques: A review

Journal of Pharmaceutical Analysis
The characterization of drug-target interactions is a key component of drug discovery, testing, and development. Affinity chromatography is one approach that can be used for this type of analysis.
David S. Hage, Sadia Sharmeen, B.K. Sajeeb, Harshana Olupathage, Md Masudur Rahman, Isaac Kyei, Samiul Alim, Nigar Sultana Pinky   +7 more
doaj   +1 more source

fMRI Data Analysis of Affinity Propagation Clustering Based on Similarity Matrix Reduction [PDF]

Jisuanji gongcheng, 2016
Affinity Propagation Clustering(APC) method shows its limitations in time complexity,data storage and clustering results while handling massive functional Magnetic Resonance Imaging(fMRI) data.Aiming at these problems,this paper proposes a new method ...
GUAN Xiuying,ZENG Weiming,WANG Nizhuan
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Investigation of substituent effect of 1-(3,3-diphenylpropyl)-piperidinyl phenylacetamides on CCR5 binding affinity using QSAR and virtual screening techniques

, 2005
A linear quantitative–structure activity relationship model is developed in this work using Multiple Linear Regression Analysis as applied to a series of 51 1-(3,3-diphenylpropyl)-piperidinyl phenylacetamides derivatives with CCR5 binding affinity.
Melagraki, G, Markopoulos, J, Georgia Melagrakia, John Markopoulosd, Antreas Afantitisa, Panayiotis A, Koutentis, PA, Olga Igglessi-markopouloua, Sarimveis, H, Haralambos Sarimveisa, Igglessi-Markopoulou, O, Afantitis, A   +11 more
core   +1 more source

A Bioinformatics Platform for General Affinity Purification-Mass Spectrometry Analysis

Zhipu Xuebao
Protein-protein interactions (PPIs) are fundamental to cellular regulation, governing complex biological processes through the assembly of stable or transient molecular machineries. Affinity purification coupled with mass spectrometry (AP-MS) has emerged
Qian-ning ZHANG, An HE, Yuan LI, Mi KE, Rui-jun TIAN   +4 more
doaj   +1 more source

The Varieties of the Psychedelic Experience: A Preliminary Study of the Association Between the Reported Subjective Effects and the Binding Affinity Profiles of Substituted Phenethylamines and Tryptamines

Frontiers in Integrative Neuroscience, 2018
Classic psychedelics are substances of paramount cultural and neuroscientific importance. A distinctive feature of psychedelic drugs is the wide range of potential subjective effects they can elicit, known to be deeply influenced by the internal state of
Federico Zamberlan, Federico Zamberlan, Camila Sanz, Rocío Martínez Vivot, Rocío Martínez Vivot, Carla Pallavicini, Carla Pallavicini, Fire Erowid, Earth Erowid, Enzo Tagliazucchi, Enzo Tagliazucchi, Enzo Tagliazucchi   +11 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Modeling of protein adsorption in membrane affinity chromatography

, 2004
For the design of affinity membranes, protein adsorption in membrane affinity chromatography (MAC) was studied by frontal analysis. According to fast mass transfer, small thickness of affinity membranes and high affinity between the protein and the ...
Hao, WQ, Wang, JD, Chen, ZA, Liu, XL
core   +1 more source

Improved elution strategy and new monoclonal anti-biotin antibody for LC-MS/MS characterization of protein biotinylation sites

Biochemistry and Biophysics Reports
Biotin labeling in combination with mass spectrometry has been widely applied in large-scale biological studies, such as determination of protein partners, protein subcellular localization, and protein post-translational modifications.
Yiying Zhu
doaj   +1 more source