Results 141 to 150 of about 733,038 (191)

Selective Affinity Propagation Ensemble Clustering

2019 IEEE Conference on Control Technology and Applications (CCTA), 2019
An ensemble clustering algorithm based on affinity propagation clustering (APC) algorithm is proposed in the paper. Different base clustering results are obtained by using APC algorithm under the selected preference parameter. However, some base clusters have little effect on the final clustering result, the “good” base clusters should be selected from
Qi Lei, Ting Li
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Affinity Selection Using Filamentous Phage Display

2013
Display of peptides on filamentous phage, phage display, is an in vitro selection technique well suited for identification of therapeutic peptide binders for a huge variety of protein targets. The peptides are identified in a process where phage libraries are subjected to affinity selection towards a particular protein target.
Mari Ann, Kulseth, Annette, Fagerlund, Astrid Hilde, Myrset   +2 more
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Kinase selectivity profiling by inhibitor affinity chromatography

Expert Review of Proteomics, 2004
As new drugs rapidly advance into clinical trials, comprehensive identification of their intracellular targets becomes fundamental for the full understanding of the molecular basis of their efficacy and toxicity. This is particularly important when the targets belong to a large family and the inhibitors recognize a conserved site among different ...
Barbara, Valsasina, Henryk M, Kalisz, Antonella, Isacchi   +2 more
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Affinity-based Media selection

Journal of Advertising Research, 2002
ABSTRACT The basic role of advertising media has been considered to be simply delivering the brand message to its target audience. However, even if the message is sufficiently delivered, it is not clear whether the audience will actively absorb it. This paper focuses on the psychological relationship between advertised brands and magazine vehicles as ...
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Affinity Selection from Biological Libraries

Science, 2002
Phage display is a simple yet powerful technology that is used to rapidly characterize protein-protein interactions from amongst billions of candidates. This widely practiced technique is used to map antibody epitopes, create vaccines and to engineer peptides, antibodies and other proteins as both diagnostic tools and as human therapeutics. We overview
James F. Smothers, Steven Henikoff, Paul Carter   +2 more
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Low-affinity peptides and T-cell selection

Trends in Immunology, 2009
The dual requirement for T cells to recognize a particular major histocompatibility complex (MHC) antigen presenting a foreign peptide and to lack strong reactivity with a complex of the same molecule when bound to a self-peptide, is attained by thymic positive and negative selection processes, the molecular details of which are currently only ...
Andreas, Ziegler, Claudia A, Müller, Rainer A, Böckmann, Barbara, Uchanska-Ziegler   +3 more
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Spiropiperidines as high-affinity, selective .sigma. ligands.

Journal of Medicinal Chemistry, 1992
A variety of achiral conformationally restricted spirocyclic piperidines have been prepared in an attempt to investigate the functional role of the central sigma recognition site. All the compounds possessed a lipophilic N-substituent incorporating either a tetralin, indan, or benzocycloheptane skeleton.
M S, Chambers, R, Baker, D C, Billington, A K, Knight, D N, Middlemiss, E H, Wong   +5 more
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Affinity Peptidomics: Peptide Selection and Affinity Capture on Hydrogels and Microarrays

2009
Affinity peptidomics relies on the successfully proven approach used widely in mass-spectrometry-based protein analysis, where protein samples are proteolytically digested prior to the analysis. Unlike traditional proteomic analyses, affinity peptidomics employs affinity detection instead of, or in addition to, the mass-spectrometry detection. Affinity
Fan, Zhang, Anna, Dulneva, Julian, Bailes, Mikhail, Soloviev   +3 more
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Affinity-selected heparan sulfate for bone repair

Biomaterials, 2013
Bone morphogenetic protein (BMP)-2 is a potent bone healing compound produced at sites of bone trauma. Here we present a therapeutic strategy to harness the activity of endogenously produced BMP-2 by delivery of an affinity-matched heparan sulfate (HS) glycos aminoglycan biomaterial that increases the bioavailability, bioactivity and half-life of this ...
S, Murali, B, Rai, C, Dombrowski, J L J, Lee, Z X H, Lim, D S, Bramono, L, Ling, T, Bell, S, Hinkley, S S, Nathan, J H, Hui, H K, Wong, V, Nurcombe, S M, Cool   +13 more
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Not Elective but Selective Affinities

Journal of Classical Sociology, 2005
Max Weber’s ambivalent attitude to the application of the concepts of selection and adaptation to the study of cultural and social evolution is readily understandable in view of his scepticism about the reducibility of sociology to biology and his suspicion that selectionist explanations will turn out on close inspection to be either value-laden or ...
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