Results 221 to 230 of about 329,197 (260)

The data-selective constrained affine-projection algorithm

2001 IEEE International Conference on Acoustics, Speech, and Signal Processing. Proceedings (Cat. No.01CH37221), 2001
This paper introduces a constrained version of the recently proposed set-membership affine projection algorithm based on the set-membership criteria for coefficient update. The algorithm is suitable for linearly constrained minimum-variance filtering applications.
Stefan Werner 0001, José Antonio Apolinário, Marcello L. R. de Campos   +2 more
openaire   +1 more source

Kinase selectivity profiling by inhibitor affinity chromatography

Expert Review of Proteomics, 2004
As new drugs rapidly advance into clinical trials, comprehensive identification of their intracellular targets becomes fundamental for the full understanding of the molecular basis of their efficacy and toxicity. This is particularly important when the targets belong to a large family and the inhibitors recognize a conserved site among different ...
Barbara, Valsasina, Henryk M, Kalisz, Antonella, Isacchi   +2 more
openaire   +2 more sources

The affinity, selectivity and biological activity of telenzepine enantiomers

European Journal of Pharmacology, 1989
The binding of the enantiomers of telenzepine to muscarinic receptor subtypes present in guinea-pig cerebral cortex, myocardium and salivary glands has been examined. The (+) enantiomer is more potent in all assays and exhibits a greater selectivity than the (-) enantiomer for the different receptor subtypes.
C, Schudt, R, Boer, M, Eltze, R, Riedel, G, Grundler, N J, Birdsall   +5 more
openaire   +2 more sources

Spiropiperidines as high-affinity, selective .sigma. ligands.

Journal of Medicinal Chemistry, 1992
A variety of achiral conformationally restricted spirocyclic piperidines have been prepared in an attempt to investigate the functional role of the central sigma recognition site. All the compounds possessed a lipophilic N-substituent incorporating either a tetralin, indan, or benzocycloheptane skeleton.
M S, Chambers, R, Baker, D C, Billington, A K, Knight, D N, Middlemiss, E H, Wong   +5 more
openaire   +2 more sources

An Affine Projection Algorithm With Update-Interval Selection

IEEE Transactions on Signal Processing, 2013
This paper presents a mean-square deviation (MSD) analysis of the periodic affine projection algorithm (P-APA) and two update-interval selection methods to achieve improved performance in terms of the convergence and the steady-state error. The MSD analysis of the P-APA considers the correlation between the weight error vector and the measurement noise
JaeWook Shin, Chang Hee Lee, NamWoong Kong, PooGyeon Park   +3 more
openaire   +2 more sources

Selecting aptamers with programmed affinities

Nature Chemistry, 2023
Ping Song, Chunhai Fan
openaire   +2 more sources

Low-affinity peptides and T-cell selection

Trends in Immunology, 2009
The dual requirement for T cells to recognize a particular major histocompatibility complex (MHC) antigen presenting a foreign peptide and to lack strong reactivity with a complex of the same molecule when bound to a self-peptide, is attained by thymic positive and negative selection processes, the molecular details of which are currently only ...
Andreas, Ziegler, Claudia A, Müller, Rainer A, Böckmann, Barbara, Uchanska-Ziegler   +3 more
openaire   +2 more sources

Affinity-based Media selection

Journal of Advertising Research, 2002
ABSTRACT The basic role of advertising media has been considered to be simply delivering the brand message to its target audience. However, even if the message is sufficiently delivered, it is not clear whether the audience will actively absorb it. This paper focuses on the psychological relationship between advertised brands and magazine vehicles as ...
openaire   +1 more source

Melanin-affinic thioureas as selective melanoma seekers

Melanoma Research, 1991
2-Thiouracil and some related thioureas are receiving growing interest as selective melanoma seekers. They are incorporated into growing melanin, apparently due to covalent binding to dopaquinone, and the adduct is gradually trapped in the melanin polymer during its formation.
openaire   +2 more sources

Selection of phage antibodies by binding affinity. Mimicking affinity maturation.

Journal of molecular biology, 1992
We describe a process, based on display of antibodies on the surface of filamentous bacteriophage, for selecting antibodies either by their affinity for antigen or by their kinetics of dissociation (off-rate) from antigen. For affinity selection, phage are mixed with small amounts of soluble biotinylated antigen (less than 1 microgram) such that the ...
R E, Hawkins, S J, Russell, G, Winter
openaire   +1 more source