Results 1 to 10 of about 392,809 (314)

Reporting about value creation – Evidence from the Netherlands [PDF]

MAB, 2020
Value creation is a key element in transparent and informative reporting, as it gives a better impression of the risks and opportunities that a company faces.
Kavita Nandram, Mohamed El Harchaoui
doaj   +3 more sources

Identification of signaling pathways modifying human dopaminergic neuron development using a pluripotent stem cell-based high-throughput screening automated system: purinergic pathways as a proof-of-principle

Frontiers in Pharmacology, 2023
Introduction: Alteration in the development, maturation, and projection of dopaminergic neurons has been proposed to be associated with several neurological and psychiatric disorders.
Claire Boissart, Marie Lasbareilles, Marie Lasbareilles, Marie Lasbareilles, Johana Tournois, Laure Chatrousse, Thifaine Poullion, Alexandra Benchoua, Alexandra Benchoua   +8 more
doaj   +1 more source

NanoLocz: Image analysis platform for AFM, high-speed AFM and localization AFM

Small Methods, 2023
AbstractNanoLocz is an open-source computer program designed for high-throughput automatic processing and single-particle analysis of Atomic Force Microscopy (AFM) image data. High-Speed AFM and Localization AFM (LAFM) enable the study of single molecules with increasingly higher spatiotemporal resolution.
Heath, G.R., Micklethwaite, E., Storer, T.M.   +2 more
openaire   +3 more sources

CRISPR/Cas9-mediated generation of human embryonic stem cell sub-lines with HPRT1 gene knockout to model Lesch Nyhan disease

Stem Cell Research, 2023
Lesch-Nyhan disease (LND) is a X-linked genetic disease affecting boys characterized by complex neurological and neuropsychiatric symptoms. LND is caused by loss of function mutations in the HPRT1 gene leading to decrease activity of hypoxanthine-guanine
Claire Boissart, Laure Chatrousse, Thifaine Poullion, Lina El-Kassar, Karine Giraud-Triboult, Alexandra Benchoua   +5 more
doaj   +1 more source

Establishment of heterozygous and homozygous SHANK3 knockout clonal pluripotent stem cells from the parental hESC line SA001 using CRISPR/Cas9

Stem Cell Research, 2023
Phelan-McDermid syndrome (PMS) is a rare genetic disease characterized by a global developmental delay with autism spectrum disorder. PMS is caused by loss of function mutations in the SHANK3 gene leading to SHANK3 protein haploinsufficiency.
Laure Chatrousse, Thifaine Poullion, Lina El-Kassar, Karine Giraud-Triboult, Claire Boissart, Peggy Sanatine, Peter Sommer, Alexandra Benchoua   +7 more
doaj   +1 more source

Contribution of Human Pluripotent Stem Cell-Based Models to Drug Discovery for Neurological Disorders

Cells, 2021
One of the major obstacles to the identification of therapeutic interventions for central nervous system disorders has been the difficulty in studying the step-by-step progression of diseases in neuronal networks that are amenable to drug screening ...
Alexandra Benchoua, Marie Lasbareilles, Johana Tournois   +2 more
doaj   +1 more source

Empirical Analysis of the Elasticity of Employment to Output Gap in the Republic of Croatia [PDF]

Interdisciplinary Description of Complex Systems, 2021
This article deals with the impact of cyclical activity of GDP on employment in the Republic of Croatia in the period from 2000 to 2020. According to the prevailing economic paradigm, employment growth follows GDP growth in the long run, but cyclical ...
Željko Kučiš, Irena Palić
doaj   +1 more source

The Future of Regenerative Medicine: Cell Therapy Using Pluripotent Stem Cells and Acellular Therapies Based on Extracellular Vesicles

Cells, 2021
The rapid progress in the field of stem cell research has laid strong foundations for their use in regenerative medicine applications of injured or diseased tissues.
Margot Jarrige, Elie Frank, Elise Herardot, Sabrina Martineau, Annabelle Darle, Manon Benabides, Sophie Domingues, Olivier Chose, Walter Habeler, Judith Lorant, Christine Baldeschi, Cécile Martinat, Christelle Monville, Lise Morizur, Karim Ben M’Barek   +14 more
doaj   +1 more source

Semi-automated optimized method to isolate CRISPR/Cas9 edited human pluripotent stem cell clones

Stem Cell Research & Therapy, 2023
Background CRISPR/Cas9 editing systems are currently used to generate mutations in a particular gene to mimic a genetic disorder in vitro. Such “disease in a dish” models based on human pluripotent stem cells (hPSCs) offer the opportunity to have access ...
Elie Frank, Michel Cailleret, Constantin Nelep, Pascal Fragner, Jérome Polentes, Elise Herardot, Lina El Kassar, Karine Giraud-Triboult, Christelle Monville, Karim Ben M’Barek   +9 more
doaj   +1 more source

SISTEMA: A large and standardized collection of transcriptome data sets for human pluripotent stem cell research

iScience, 2021
Summary: Human pluripotent stem cells have ushered in an exciting new era for disease modeling, drug discovery, and cell therapy development. Continued progress toward realizing the potential of human pluripotent stem cells will be facilitated by robust ...
Margot Jarrige, Hélène Polvèche, Alexandre Carteron, Stéphane Janczarski, Marc Peschanski, Didier Auboeuf, Cécile Martinat   +6 more
doaj   +1 more source