Results 41 to 50 of about 66,075 (218)

Salivarian Trypanosomes Have Adopted Intricate Host-Pathogen Interaction Mechanisms That Ensure Survival in Plain Sight of the Adaptive Immune System

open access: yesPathogens, 2021
Salivarian trypanosomes are extracellular parasites affecting humans, livestock and game animals. Trypanosoma brucei rhodesiense and Trypanosoma brucei gambiense are human infective sub-species of T.
Stefan Magez   +3 more
doaj   +1 more source

Cloning and Characterization of Trypanosoma congolense and T. vivax Nucleoside Transporters Reveal the Potential of P1-Type Carriers for the Discovery of Broad-Spectrum Nucleoside-Based Therapeutics against Animal African Trypanosomiasis

open access: yesInternational Journal of Molecular Sciences, 2023
African Animal Trypanosomiasis (AAT), caused predominantly by Trypanosoma brucei brucei, T. vivax and T. congolense, is a fatal livestock disease throughout Sub-Saharan Africa. Treatment options are very limited and threatened by resistance.
Marzuq A. Ungogo   +12 more
semanticscholar   +1 more source

Insights from quantitative and mathematical modelling on the proposed 2030 goal for gambiense human African trypanosomiasis (gHAT) [PDF]

open access: yes, 2019
Gambiense human African trypanosomiasis (gHAT) is a parasitic, vector-borne neglected tropical disease that has historically affected populations across West and Central Africa and can result in death if untreated.
Aliee, Maryam   +10 more
core   +1 more source

Challenges facing the elimination of sleeping sickness in west and central Africa: sustainable control of animal trypanosomiasis as an indispensable approach to achieve the goal

open access: yesParasites & Vectors, 2015
African trypanosomiases are infectious diseases caused by trypanosomes. African animal trypanosomiasis (AAT) remains an important threat for livestock production in some affected areas whereas human African trypanosomiasis (HAT) is targeted for ...
Gustave Simo, Jean Baptiste Rayaisse
doaj   +1 more source

Delineating neuroinflammation, parasite CNS invasion, and blood-brain barrier dysfunction in an experimental murine model of human African trypanosomiasis [PDF]

open access: yes, 2017
Although Trypanosoma brucei spp. was first detected by Aldo Castellani in CSF samples taken from sleeping sickness patients over a century ago there is still a great deal of debate surrounding the timing, route and effects of transmigration of the ...
Bradley, Barbara   +2 more
core   +1 more source

Animal African Trypanosomiasis: Time to Increase Focus on Clinically Relevant Parasite and Host Species [PDF]

open access: yesTrends in Parasitology, 2016
Animal African trypanosomiasis (AAT), caused by Trypanosoma congolense and Trypanosoma vivax, remains one of the most important livestock diseases in sub-Saharan Africa, particularly affecting cattle. Despite this, our detailed knowledge largely stems from the human pathogen Trypanosoma brucei and mouse experimental models.
Morrison, Liam   +3 more
openaire   +3 more sources

A mathematical model for evaluating the role of trypanocide treatment of cattle in the epidemiology and control of Trypanosoma brucei rhodesiense and T. b. gambiense sleeping sickness in Uganda

open access: yesParasite Epidemiology and Control, 2019
Background: Human and animal African trypanosomiases impose a large economic and health burden in their endemic regions. Large strides have been made in the control of human African trypanosomiasis (HAT), yet these efforts have largely focused on the non-
Julianne Meisner   +2 more
doaj   +1 more source

Nanobodies as tools to understand, diagnose, and treat African trypanosomiasis [PDF]

open access: yes, 2017
African trypanosomes are strictly extracellular protozoan parasites that cause diseases in humans and livestock and significantly affect the economic development of sub-Saharan Africa.
Caljon, Guy   +5 more
core   +1 more source

In Vitro Mechanism of Action of Acanthospermum hispidum in Trypanosoma brucei

open access: yesAdvances in Pharmacological and Pharmaceutical Sciences, 2022
African trypanosomiasis is a major neglected tropical disease with significant health and economic concerns in sub-Saharan Africa. In the absence of vaccines for African trypanosomiasis, there is a consideration for alternative sources of chemotherapy ...
Aboagye Kwarteng Dofuor   +4 more
doaj   +1 more source

African animal trypanocide resistance: A systematic review and meta-analysis

open access: yesFrontiers in Veterinary Science, 2023
Background African animal trypanocide resistance (AATr) continues to undermine global efforts to eliminate the transmission of African trypanosomiasis in endemic communities. The continued lack of new trypanocides has precipitated drug misuse and overuse,
K. I. Kasozi, E. MacLeod, S. Welburn
semanticscholar   +1 more source

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