Trypanocidal and leishmanicidal activity of six limonoids [PDF]
, 2020 Six limonoids [kotschyienone A and B (1, 2), 7-deacetylgedunin (3), 7-deacetyl-7-oxogedunin (4), andirobin (5) and methyl angolensate (6)] were investigated for their trypanocidal and leishmanicidal activities using bloodstream forms of Trypanosoma ...
A-E Hay +30 more
core +3 more sources
Molecular epidemiology of African sleeping sickness [PDF]
, 2009 Human sleeping sickness in Africa, caused by Trypanosoma brucei spp. raises a number of questions. Despite the widespread distribution of the tsetse vectors and animal trypanosomiasis, human disease is only found in discrete foci which periodically give ...
A. TAIT +5 more
core +2 more sources
Anilinoquinoline based inhibitors of trypanosomatid proliferation.
PLoS Neglected Tropical Diseases, 2018 We recently reported the medicinal chemistry re-optimization of a series of compounds derived from the human tyrosine kinase inhibitor, lapatinib, for activity against Plasmodium falciparum.
Lori Ferrins +11 more
doaj +1 more source
The study of trypanosome species circulating in domestic animals in two human African trypanosomiasis foci of Côte d'Ivoire identifies pigs and cattle as potential reservoirs of Trypanosoma brucei gambiense. [PDF]
PLoS Neglected Tropical Diseases, 2017 BACKGROUND:Important control efforts have led to a significant reduction of the prevalence of human African trypanosomiasis (HAT) in Côte d'Ivoire, but the disease is still present in several foci.
Martial Kassi N'Djetchi +15 more
doaj +1 more source
Comparative clinico-haematological analysis in young Zebu cattle experimentally infected with Trypanosoma vivax isolates from tsetse infested and non-tsetse infested areas of Northwest Ethiopia [PDF]
, 2015 Background: Ethiopia, particularly in the Northwest region, is affected by both tsetse and non-tsetse fly transmitted trypanosomosis, with significant impact on livestock productivity. The aim of this study was to determine and compare clinical findings
Abebe, Getachew +5 more
core +2 more sources
Parasites & Vectors, 2014 Background African animal trypanosomiasis (AAT) is considered to be one of the greatest constraints to livestock production and livestock-crop integration in most African countries.
Dennis Muhanguzi +6 more
doaj +1 more source
PLoS Neglected Tropical Diseases, 2021 In the Maasai Steppe, public health and economy are threatened by African Trypanosomiasis, a debilitating and fatal disease to livestock (African Animal Trypanosomiasis -AAT) and humans (Human African Trypanosomiasis-HAT), if not treated.
Happiness Jackson Nnko +4 more
doaj +1 more source
Genetic and Phenotypic Features of the Five Known Polyaminopathies: A Critical Narrative Review
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT Polyaminopathies are a recently described family of rare genetic neurodevelopmental disorders. Polyaminopathies disrupt the biosynthesis of the primary polyamines: putrescine, spermidine, and spermine. Snyder–Robinson syndrome results from hemizygous loss‐of‐function variants in the spermine synthase (SMS) gene, resulting in decreased or ...
Elizabeth A. VanSickle +26 more
wiley +1 more source
International Journal for Parasitology: Drugs and Drug Resistance, 2018 Trypanosoma congolense is a protozoan parasite that is transmitted by tsetse flies, causing African Animal Trypanosomiasis, also known as Nagana, in sub-Saharan Africa. Nagana is a fatal disease of livestock that causes severe economic losses.
M. Gysin +5 more
doaj +1 more source
Design of an Epitope-Based Vaccine Ensemble for Animal Trypanosomiasis by Computational Methods
Vaccines, 2020 African animal trypanosomiasis is caused by vector-transmitted parasites of the genus Trypanosoma. T. congolense and T. brucei brucei are predominant in Africa; T. evansi and T. vivax in America and Asia.
Lucas Michel-Todó +5 more
doaj +1 more source