Results 21 to 30 of about 1,738 (148)

Targeting Brutons Tyrosine Kinase in Chronic Lymphocytic Leukemia at the Crossroad between Intrinsic and Extrinsic Pro-survival Signals [PDF]

, 2016
Chemo immunotherapies for chronic lymphocytic leukemia (CLL) showed a positive impact on clinical outcome, but many patients relapsed or become refractory to the available treatments.
Facco, Monica, Frezzato, Federica, Martini, Veronica, Semenzato, Gianpietro, Severin, Filippo, Trentin, Livio, Trimarco, Valentina, Visentin, Andrea   +7 more
core   +1 more source

Role of Bruton's tyrosine kinase in B cells and malignancies [PDF]

, 2018
Bruton's tyrosine kinase (BTK) is a non-receptor kinase that plays a crucial role in oncogenic signaling that is critical for proliferation and survival of leukemic cells in many B cell malignancies. BTK was initially shown to be defective in the primary
Dammeijer, F. (Floris), Hendriks, R.W. (Rudi), Pal Singh, S. (Simar)   +2 more
core   +4 more sources

Severe platelet dysfunction in NHL patients receiving ibrutinib is absent in patients receiving acalabrutinib [PDF]

, 2017
The Bruton’s tyrosine kinase (Btk) inhibitor ibrutinib induces platelet dysfunction and causes increased risk of bleeding. Off-target inhibition of Tec is believed to contribute to platelet dysfunction and other side-effects of ibrutinib.
Appleby, Niamh, Bruce, David, Bye, Alex P., Desborough, Michael J., Gibbins, Jon M., Hildyard, Catherine A. T., Hughes, Craig E., Kriek, Neline, Nock, Sophie H., Sage, Tanya, Unsworth, Amanda J.   +10 more
core   +2 more sources

Delayed diagnosis of X-linked agammaglobulinaemia in a boy with recurrent meningitis

BMC Neurology, 2019
Background X-linked agammaglobulinaemia (XLA) is a rare inherited primary immunodeficiency disease characterized by the B cell developmental defect, caused by mutations in the gene coding for Bruton’s tyrosine kinase (BTK), which may cause serious ...
Ya-Ni Zhang, Yuan-Yuan Gao, Si-Da Yang, Bin-Bin Cao, Ke-Lu Zheng, Ping Wei, Lian-Feng Chen, Wen-Xiong Chen   +7 more
doaj   +1 more source

Future therapeutic targets in rheumatoid arthritis? [PDF]

, 2017
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by persistent joint inflammation. Without adequate treatment, patients with RA will develop joint deformity and progressive functional impairment.
A Balanescu, A Bilancio, A Del Prete, A Maas, AB Avci, AB Satterthwaite, AD Cook, AG Semb, AJ Fleetwood, AJ Fleetwood, AJ Mohamed, AL Bell, AL Cornish, AM Condliffe, AR Pettit, AW Lieshout van, B Ludewig, BF Nashed, BJ Jenkins, BZ Li, C Baerwald, C Meune, C Rommel, C Schindler, C Voigtlander, CA Martin, CJ Heijnen, CM Hilkens, CV Brenol, D Heijde van der, DH Solomon, DJ Rawlings, DL Bellinger, DM Nance, DS Lim, DT Patton, E Banham-Hall, E Clayton, E Feist, E Hirsch, E Martin, E Thomas, EB Lee, EC Tsark, EK Evans, F Berenbaum, F Bussolino, F Ramadani, FA Koopman, FA Koopman, FM Foster, G Hansen, GM Bell, GR Burmester, GR Burmester, H Evrengul, H Wang, Iain B. McInnes, IC Eijk van, IJ Elenkov, IK Campbell, J Askling, J Jang, J Kremer, JA Avina-Zubieta, JA Hamilton, JC Barrientos, JE Park, JM Kremer, JM Waldburger, JS Rawlings, JS Smolen, K Imada, K Okkenhaug, K Okkenhaug, K Okkenhaug, K Pavelka, K Reif, K Shuai, K Thiele, K Yamaoka, KL Winthrop, KP MacDonald, KS Nair, L Conti, L Jansson, L Senolt, L Zhang, L Zou, LC Cantley, LG Schipper, LJ Courtright, LV Borovikova, M Camps, M Dougados, M Field, M Gilliet, M Pesu, M Rosas-Ballina, M Skoberne, M Skoberne, M Soubrier, M Westman, MA Maanen van, MA Maanen van, MA Maanen van, MB Torchinsky, MC Genovese, MC Genovese, MC Genovese, MC Genovese, MC Genovese, MC Genovese, MC Lebre, MC Lebre, MG Roncarolo, MJ Peters, MS Ahmed, MS Thomas, N Krishnamoorthy, N Sato, NJ Gullick, P Geborek, P Norman, P Sujobert, PC Heinrich, PC Taylor, Q Yang, R Fleischmann, R Fleischmann, RA Maldonado, RF Vollenhoven van, RH Straub, RM Buijs, RM Steinman, RM Steinman, S Hayer, S Kleinau, S Mukhopadhyay, S Mukhopadhyay, S Somersan, S Tsukada, SA Provan, ST Jou, T Leizer, T Li, Tommy Tsang Cheung, TR Radstake, WJ Jonge de, WN Khan, Y Ren, Y Xu, YP Goekoop-Ruiterman, Z Li, Z Pan   +154 more
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Invasive Aspergillosis in Patients Treated With Ibrutinib

, 2020
HemaSphere, Volume 4, Issue 2, April 2020.
Moritz Fürstenau, Florian Simon, Oliver A. Cornely, Tillman Hicketier, Barbara Eichhorst, Michael Hallek, Sibylle C. Mellinghoff   +6 more
wiley   +1 more source

Effects of BTK signalling in pathogenic microorganism infections

Journal of Cellular and Molecular Medicine, Volume 23, Issue 10, Page 6522-6529, October 2019., 2019
Abstract As a cytoplasmic protein tyrosine kinase, Bruton's tyrosine kinase (Btk) is widely considered as a vital kinase in many aspects of different physiologic processes. It is engaged in many important signalling pathways related to the immune response, such as the B cell receptor pathway, pattern‐recognition receptor pathway, and triggering ...
Bingjue Ye, Cheng Zhou, Huiting Guo, Min Zheng   +3 more
wiley   +1 more source

Disseminated Cryptococcal Disease in a Patient with Chronic Lymphocytic Leukemia on Ibrutinib

Case Reports in Infectious Diseases, Volume 2016, Issue 1, 2016., 2016
Cryptococcus is a unique environmental fungus that can cause disease most often in immunocompromised individuals with defective cell‐mediated immunity. Chronic lymphocytic leukemia (CLL) is not known to be a risk factor for cryptococcal disease although cases have been described mainly in patients treated with agents that suppress cell‐mediated ...
Koh Okamoto, Laurie A. Proia, Patricia L. Demarais, Pau Montesinos Fernández   +3 more
wiley   +1 more source

Itk: The Rheostat of the T Cell Response

Journal of Signal Transduction, Volume 2011, Issue 1, 2011., 2011
The nonreceptor tyrosine kinase Itk plays a key role in TCR‐initiated signaling that directly and significantly affects the regulation of PLCγ1 and the consequent mobilization of Ca2+. Itk also participates in the regulation of cytoskeletal reorganization as well as cellular adhesion, which is necessary for a productive T cell response.
Juris A. Grasis, Constantine D. Tsoukas, Fred Schaper   +2 more
wiley   +1 more source

The European internet-based patient and research database for primary immunodeficiencies: results 2006-2008 [PDF]

, 2009
Primary immunodeficiencies (PID) are rare diseases; therefore transnational studies are essential to maximize the scientific outcome and to improve diagnosis and therapy.
Abuzakouk M., Bangs C., Baumann U., Beauté J., Beauté J., Benslama L., Brodszki N., Caragol I., Ciznar P., Core C., Cucuruz M., Dempster J., Dudoit Y., Dudoit Y., Duobiene R., Exley A., Farber C.M., Fasshauer M., Feighery C., Fischer A., Gathmann B., Goldacker S., Grimbacher B., Hatzistilianou M., Hörnes M., Kanariou M., Kilic S., Kindle G., Knerr V., Knerr V., Kondratenko I., Koren A., Kumararatne D., Kütükcüler N., Litzman J., Llobet P., Lucas M., Mahlaoui N., Marodi L., Marques L., Meyts I., Micol R., Niehues T., Notarangelo L., Papadopoulou Alataki E., Paschenko O., Pasic S., PIGNATA, CLAUDIO, Plebani A., Reda S., Reisli I., Richter D., Ritterbusch H., Sanal O., Savchak I., Shchebet S., Shcherbina A., Soler P., Sollinger F., Stimm H., Szaflarska A., Thon V., Tierney P., Touitou I., Trachana M., Velbri S., Viemann D., Witte T., Wittkowski H., Wolska B., Yegin O.   +70 more
core   +1 more source