Results 31 to 40 of about 1,349 (113)

"Screening of the Bruton Tyrosine Kinase (BTK) Gene Mutations in 13 Iranian Patients with Presumed X-Linked Agammaglobulinemia "

Iranian Journal of Allergy, Asthma and Immunology, 2004
X-linked agammaglobulinemia (XLA) is an immunodeficiency caused by mutations in the Bruton tyrosine kinase (Btk) gene. In order to identify the mutations in Btk gene in Iranian patients with antibody deficiency, 13 male patients with an XLA phenotype ...
"Asghar Aghamohammadi, Nima Parvaneh, Hirokazu Kanegana, Mostafa Moin, Ali Akbar Amirzargar, Abolhassan Farhoudi, Zahra Pourpak, Masoud Movahedi, Mohammad Gharagozlou, Nima Rezaei, Takeshi Futatani, Toshio Miyawaki "   +11 more
doaj  

Molecular studies on Burton's tyrosine kinase [PDF]

, 1999
X-Linked agammaglobulinaemia (XLA) is a humoral immunodeficiency resulting from a block in the B cell maturation pathway at the pre-B cell stage. Affected males have normal numbers of pre-B cells in the bone marrow but virtually no mature B cells in the ...
Gaspar, Hubert Baburaj
core  

Importance of B cell co-stimulation in CD4(+) T cell differentiation: X-linked agammaglobulinaemia, a human model

, 2011
P>We were interested in the question of whether the congenital lack of B cells actually had any influence on the development of the T cell compartment in patients with agammaglobulinaemia.
E Giorda, I Quinti, Warnatz, Klaus, B Grimbacher, S. Workman, Enright, Victoria, E. Giorda, S Workman, M. Perro, M Perro, Workman, Sarita, K. Warnatz, Perro, M., V. Lougaris, K Warnatz, Giorda, Ezio, J. Birmelin, Birmelin, Jennifer, Baronio, Manuela, QUINTI, Isabella, B. Grimbacher, Lougaris, Vassilios, H Martini, Grimbacher, Bodo, V. Enright, M Baronio, V Enright, J Birmelin, MARTINI, HELENE, M. Baronio, V Lougaris   +30 more
core   +1 more source

Bruton’s tyrosine kinase inhibitors impair FcγRIIa-mediated platelet responses to bacteria in chronic lymphocytic leukaemia

, 2021
Ibrutinib is highly effective in the treatment of chronic lymphocytic leukaemia (CLL), disrupting B cell receptor signalling through the inhibition of Bruton’s tyrosine kinase (Btk).
Naylor-Adamson, Leigh
core   +1 more source

Molecular interactions of bruton's tyrosine kinase [PDF]

, 1997
X-linked agammaglobulinaemia (XLA) is a primary immunodeficiency disorder characterised by a dramatic reduction in the numbers of peripheral B cells and immunoglobulins of all isotypes.
Cory, Giles Oliver Cholmondeley
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A new case of autosomal recessive agammaglobulinaemia with impaired pre-B cell differentiation due to a large deletion of the IGH locus [PDF]

, 2002
Males with X-linked agammaglobulinaemia (XLA) due to mutations in the Bruton tyrosine kinase gene constitute the major group of congenital hypogammaglobulinaemia with absence of peripheral B cells.
Milili, M, Blanco-Betancourt, C, Vasconcelos, J, Nogueiras, A, Santos, E, Castro e Melo, J, Schiff, C, Antunes, H   +7 more
core  

Constitutive protein-protien interactions regulate activity of Bruton´s-Tyrosine-Kinase in B-cells

, 2017
Die Protein-Tyrosin-Kinase Btk ist ein entscheidendes Effektorprotein in der ITAM-abhängigen B-Zell-Antigen-Rezeptor (BZR)-Signalkaskade. Ihr Fehlen oder Dysfunktion führt beim Menschen zur X-gekoppelten Agammaglobulinämie (XLA).
Schulze, Wiebke
core   +1 more source

Inhibidores de la tirosina quinasa de bruton: Nuevo enfoque en el tratamiento de la esclerosis múltiple [PDF]

, 2023
La esclerosis múltiple es una enfermedad autoinmune que afecta al sistema nervioso central (SNC). Se diagnostica con mayor frecuencia entre los 20 y 40 años, afectando más a las mujeres que a los hombres y siendo una causa de discapacidad importante ...
Martínez Lobo, Javier
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Bronchiectasis and deteriorating lung function in agammaglobulinaemia despite immunoglobulin replacement therapy

, 2017
\ua9 2017 British Society for Immunology. Immunoglobulin replacement therapy enhances survival and reduces infection risk in patients with agammaglobulinaemia.
Alachkar H, Bangs C, Herriot R, Shillitoe B, Burns SO, Buckland M, Jolles MS, Stubbs A, Edgar JD, Arkwright PD, Thomas M, Arumugakani G, Mcdermott E   +12 more
core  

Genomic organization of mouse and human Bruton's agammaglobulinemia tyrosine kinase (Btk) loci.

, 1994
Btk is a cytoplasmic protein tyrosine kinase (PTK) that has been directly implicated in the pathogenesis of X-linked agammaglobulinaemia (XLA) in humans and X-linked immunodeficiency (Xid) in mice. We have isolated phage and cosmid clones that allowed us
Nilsson, L, Parkinson, E, Larsson, I, Shiels, H, Jin, H, Khan, W N, Thomas, J D, Khan, WN, Thomas, JD, Müller, S, Brandén, L, Sideras, P   +11 more
core   +1 more source