Results 41 to 50 of about 1,349 (113)

Elevated cytokine production restores bone resorption by human Btk-deficient osteoclasts.

, 2010
Mutations in Bruton's tyrosine kinase (Btk) cause the B-cell disorder X-linked agammaglobulinaemia (XLA) in humans, but the effect of Btk deficiency in human bone health has not been investigated previously.
Horwood, Nicole J, Webster, D, Danks, L, Workman, Sarita, Nicole J Horwood, Sarita Workman, Workman, S, Horwood, NJ, Danks, Lynett, Webster, David, Lynett Danks, David Webster   +11 more
core   +1 more source

Host-pathogen interactions in Campylobacter infections: the host perspective

, 2008
Campylobacter is a major cause of acute bacterial diarrhea in humans worldwide. This study was aimed at summarizing the current understanding of host mechanisms involved in the defense against Campylobacter by evaluating data available from three sources:
Dep Infectieziekten Immunologie, Advances in Veterinary Medicine, Krogfelt, K.A., Robert J. Owen, Pelt, W., van, Karen A. Krogfelt, Shaun A. Cawthraw, Krogfelt, K., Strategic Infection Biology, Janssen, R., Wagenaar, J.A., van Pelt, W., Riny Janssen, Wilfrid van Pelt, Cawthraw, S.A., Jaap A. Wagenaar, Owen, R.J., Cawthraw, S., Owen, R.   +18 more
core   +1 more source

Signaling by Toll-like receptors 8 and 9 requires Bruton\u27s tyrosine kinase.

, 2007
Toll-like receptors (TLRs) are a primary surveillance system for the detection of pathogens and are crucial to the activation of host defense. TLR7 and TLR8 sense single-stranded RNA from viruses or host ribonucleoproteins and synthetic imidazoquinolines
FEIGHERY, CONLETH FRANCIS, O\u27NEILL, LUKE ANTHONY JOHN, DOYLE, SARAH LOUISE   +2 more
core  

Analysis of Btk mutations in patients with X-linked agammaglobulinaemia (XLA) and determination of carrier status in normal female relatives: a nationwide study of Btk deficiency in Greece

, 2001
Bruton’s tyrosine kinase (Btk) is a nonreceptor tyrosine kinase, critical for B-cell development and function. Mutations that inactivate this kinase were found in families with X-linked agammaglobulinaemia (XLA).
Kanariou, M, Constantopoulos, A, Pardali, E, Kanakoudi-Tsakalidou, F, Vihinen, M, Papadopoulou-Alataki, E, Kartalis, G, Speletas, M, Ritis, K, Arvanitidis, K, Sideras, P   +10 more
core  

Flow cytometry analysis of the expression of FCy and complement receptors in monocytes of X-linked agammaglobulinaemia and common variable immunodeficiency patients [PDF]

, 2018
Orientador: Maria Marluce dos Santos VilelaTese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciencias MedicasResumo: Recentemente, demonstramos defeitos na fagocitose e quimiotaxia de monócitos em pacientes com agamaglobulinemia ligada ...
Amoras, Ana Lidia Braga
core  

Анализ генеалогических данных у взрослых с первичными иммунодефицитами

, 2015
This study was aimed at analysis of pedigrees of adult patients with primary immunodeficiency (PID). Methods. We examined 94 adults with primary immunodeficiency and 217 adults without this disease.
В. Н. Шершнев, V. N. Shershnev, M. L. Karakina, I. A. Tuzankina, М. Л. Каракина, И. А. Тузанкина   +5 more
core   +1 more source

Characterisation of CD8neg and CD8+ human natural killer cell subsets [PDF]

, 2012
NK cells are CD3neg CD56+ lymphocytes that constitute about 10-15% of peripheral blood lymphocytes. They have an innate ability to recognise and kill virus infected cells and tumour cells.
Abdalla, Ibrahim.I.I.
core  

Evaluation of lentivirus-mediated reconstitution of the B-cell compartment in XLA patient-derived CD34+ cells in humanised mice

, 2016
X-Linked Agammaglobulinaemia (XLA) is a primary immune deficiency resulting in an absence of B-cells and antibody production due to mutations in the Bruton’s tyrosine kinase (Btk) gene.
Wootton, Virginia
core  

Novel BTK inhibitors and degraders for relapsed/refractory CLL/SLL: latest updates from ASH 2025 annual meeting. [PDF]

J Hematol Oncol
Sharma P, Jiang H, Liu D.
europepmc   +1 more source

Gastroenterological disorders in inborn errors of immunity. Part 2 A. Overview of selected diseases. [PDF]

Prz Gastroenterol
Napiórkowska-Baran K, Treichel P, Koperska K, Kudrej O, Mućka N, Rajewska A, Wawrzeńczyk A, Bartuzi Z.   +7 more
europepmc   +1 more source