Results 21 to 30 of about 1,349 (113)

Delayed diagnosis of X-linked agammaglobulinaemia in a boy with recurrent meningitis

BMC Neurology, 2019
Background X-linked agammaglobulinaemia (XLA) is a rare inherited primary immunodeficiency disease characterized by the B cell developmental defect, caused by mutations in the gene coding for Bruton’s tyrosine kinase (BTK), which may cause serious ...
Ya-Ni Zhang, Yuan-Yuan Gao, Si-Da Yang, Bin-Bin Cao, Ke-Lu Zheng, Ping Wei, Lian-Feng Chen, Wen-Xiong Chen   +7 more
doaj   +1 more source

Invasive Aspergillosis in Patients Treated With Ibrutinib

, 2020
HemaSphere, Volume 4, Issue 2, April 2020.
Moritz Fürstenau, Florian Simon, Oliver A. Cornely, Tillman Hicketier, Barbara Eichhorst, Michael Hallek, Sibylle C. Mellinghoff   +6 more
wiley   +1 more source

Effects of BTK signalling in pathogenic microorganism infections

Journal of Cellular and Molecular Medicine, Volume 23, Issue 10, Page 6522-6529, October 2019., 2019
Abstract As a cytoplasmic protein tyrosine kinase, Bruton's tyrosine kinase (Btk) is widely considered as a vital kinase in many aspects of different physiologic processes. It is engaged in many important signalling pathways related to the immune response, such as the B cell receptor pathway, pattern‐recognition receptor pathway, and triggering ...
Bingjue Ye, Cheng Zhou, Huiting Guo, Min Zheng   +3 more
wiley   +1 more source

Disseminated Cryptococcal Disease in a Patient with Chronic Lymphocytic Leukemia on Ibrutinib

Case Reports in Infectious Diseases, Volume 2016, Issue 1, 2016., 2016
Cryptococcus is a unique environmental fungus that can cause disease most often in immunocompromised individuals with defective cell‐mediated immunity. Chronic lymphocytic leukemia (CLL) is not known to be a risk factor for cryptococcal disease although cases have been described mainly in patients treated with agents that suppress cell‐mediated ...
Koh Okamoto, Laurie A. Proia, Patricia L. Demarais, Pau Montesinos Fernández   +3 more
wiley   +1 more source

Itk: The Rheostat of the T Cell Response

Journal of Signal Transduction, Volume 2011, Issue 1, 2011., 2011
The nonreceptor tyrosine kinase Itk plays a key role in TCR‐initiated signaling that directly and significantly affects the regulation of PLCγ1 and the consequent mobilization of Ca2+. Itk also participates in the regulation of cytoskeletal reorganization as well as cellular adhesion, which is necessary for a productive T cell response.
Juris A. Grasis, Constantine D. Tsoukas, Fred Schaper   +2 more
wiley   +1 more source

Low dose Btk inhibitors selectively block platelet activation by CLEC-2 [PDF]

, 2020
Inhibitors of the tyrosine kinase Btk have been proposed as novel antiplatelet agents. In this study we show that low concentrations of the Btk inhibitor ibrutinib block CLEC-2-mediated activation and tyrosine phosphorylation including Syk and PLCγ2 in ...
Joana Campos, Kavanagh, Diedre M, Jeremy A. Pike, Smith, Christopher W, Hayley Clifford, Clifford, Hayley, Smith, Christopher, Huissoon, Aarnoud P, Pollitt, Alice Y, Campos, Joana, Nicolson, Pip; id_orcid, Joshua Hinds, Poulter, Natalie S, Kavanagh, Deirdre, Khan, Abdullah, Alice Y. Pollitt, Stephanie Watson, Steve P. Watson, Alexander Brill, Pratt, Guy, Pike, Jeremy, Phillip L.R. Nicolson, Garcia-Quintanilla, Lourdes, Craig E. Hughes, Nicolson, Phillip L R, Huissoon, Aarnoud, Sophie H. Nock, Diedre M. Kavanagh, Watson, Steve; id_orcid, Nicolson, Phillip LR, Kavanagh, Deidre M, Khan, Abdullah O, Aarnoud P. Huissoon, Hinds, Joshua, Watson, Stephanie, Nock, Sophie H, Johannes A. Eble, Eble, Johannes A, Natalie S. Poulter, Watson, Steve P, Guy Pratt, Pratt, Dickens, Watson, Callum N, Pollitt, Alice, Hughes, Craig E, Pike, Jeremy A, Poulter, Natalie; id_orcid, Christopher W. Smith, Abdullah O. Khan, Garcia Quintanilla, Lourdes, Lourdes Garcia-Quintanilla, Brill, Alexander, Hughes, Craig, Callum N. Watson   +53 more
core   +1 more source

Identification of Btk mutations in 20 unrelated patients with X-Iinked agammaglobulinaemia (XLA)

, 1995
X-linked agammaglobulinaemia (XLA) is an inherited immunodeficiency resulting from mutations in the gene for a cytoplasmic protein tyrosine kinase (Btk).
Vorechovsky, lgor, VIHINEN, M, Vetrie, David, Hammarstróm, Lennart, Jin, Hong, Smith, C.I.E., JIN, H, VETRIE, D, Bernatowska-Matuszkiewicz, Ewa, Webster, A.D.B., Vihinen, Mauno, Sideras, Paschalis, WEBSTER, ADB, HAMMARSTROM, L, SMITH, CIE, SIDERAS, P, VORECHOVSKY, I, Bobrow, Martin, BERNATOWSKAMATUSZKIEWICZ, E, BOBROW, M   +19 more
core   +1 more source

A role for Bruton's tyrosine kinase (Btk) in platelet activation by collagen

, 1998
Bruton's tyrosine kinase (Btk) is essential for normal B-cell receptor signalling. The lack of expression of functional Btk in humans leads to the B-cell deficiency X-linked agammaglobulinaemia (XLA).
Bolen, J., Quek, L.S., Watson, S.P.
core   +1 more source

Expression of Fcγ and complement receptors in monocytes of X-linked agammaglobulinaemia and common variable immunodeficiency patients

, 2007
Summary Recently we reported that monocyte phagocytosis and chemotaxis are impaired in X-linked agammaglobulinaemia (XLA) and common variable immunodeficiency (CVI) patients.
M T N Da Silva, T Miyawaki, R L Zollner, A L B Amoras, H Kanegane, M M S Vilela   +5 more
core   +2 more sources

Absence of Bruton's tyrosine kinase (Btk) mutations in patients with acute myeloid leukaemia

, 1998
Bruton's tyrosine kinase (Btk) is a non-receptor protein tyrosine kinase (PTK) that is expressed in all haemopoietic lineages except mature T cells and plasma cells. Despite the broad range of expression.
Kanariou, M, ROSSI, PAOLO, Orlandi, P, Tsironidou, V, Rossi, P, Pardali, E, Ritis, K, Speletas, M, Sideras, P, Skordala, M, Sideras, P., Moschese, V, Kartalis, G, Bourikas, G, MOSCHESE, VIVIANA   +14 more
core   +1 more source