Results 31 to 40 of about 174,156 (175)

Invasive Aspergillosis in Patients Treated With Ibrutinib

, 2020
HemaSphere, Volume 4, Issue 2, April 2020.
Moritz Fürstenau, Florian Simon, Oliver A. Cornely, Tillman Hicketier, Barbara Eichhorst, Michael Hallek, Sibylle C. Mellinghoff   +6 more
wiley   +1 more source

Effects of BTK signalling in pathogenic microorganism infections

Journal of Cellular and Molecular Medicine, Volume 23, Issue 10, Page 6522-6529, October 2019., 2019
Abstract As a cytoplasmic protein tyrosine kinase, Bruton's tyrosine kinase (Btk) is widely considered as a vital kinase in many aspects of different physiologic processes. It is engaged in many important signalling pathways related to the immune response, such as the B cell receptor pathway, pattern‐recognition receptor pathway, and triggering ...
Bingjue Ye, Cheng Zhou, Huiting Guo, Min Zheng   +3 more
wiley   +1 more source

Disseminated Cryptococcal Disease in a Patient with Chronic Lymphocytic Leukemia on Ibrutinib

Case Reports in Infectious Diseases, Volume 2016, Issue 1, 2016., 2016
Cryptococcus is a unique environmental fungus that can cause disease most often in immunocompromised individuals with defective cell‐mediated immunity. Chronic lymphocytic leukemia (CLL) is not known to be a risk factor for cryptococcal disease although cases have been described mainly in patients treated with agents that suppress cell‐mediated ...
Koh Okamoto, Laurie A. Proia, Patricia L. Demarais, Pau Montesinos Fernández   +3 more
wiley   +1 more source

Research-based flow cytometry assays for pathogenic assessment in the human B-cell biology of gene variants revealed in the diagnosis of inborn errors of immunity: a Bruton’s tyrosine kinase case-study [PDF]

, 2023
IntroductionInborn errors of immunity (IEI) are an expanding group of rare diseases whose field has been boosted by next-generation sequencing (NGS), revealing several new entities, accelerating routine diagnoses, expanding the number of atypical ...
B. González Martínez, E. López Granados, E. López Granados, E. López Granados, J. Marty Lobo, K. Reche Yebra, L. del Pino-Molina, L. del Pino-Molina, L. Y. Bravo Gallego, L. Y. Bravo Gallego, M. Bravo García-Morato, M. Bravo García-Morato, M. Bravo García-Morato, M. van der Burg, R. Rodríguez Pena, R. Rodríguez Pena, R. Rodríguez Pena, Y. Soto Serrano   +17 more
core   +4 more sources

Itk: The Rheostat of the T Cell Response

Journal of Signal Transduction, Volume 2011, Issue 1, 2011., 2011
The nonreceptor tyrosine kinase Itk plays a key role in TCR‐initiated signaling that directly and significantly affects the regulation of PLCγ1 and the consequent mobilization of Ca2+. Itk also participates in the regulation of cytoskeletal reorganization as well as cellular adhesion, which is necessary for a productive T cell response.
Juris A. Grasis, Constantine D. Tsoukas, Fred Schaper   +2 more
wiley   +1 more source

Bruton’s Disease [PDF]

, 2015
Bruton’s disease, in other terms X-linked agammaglobulinemia (XLA), is the first reported primary immunodeficiency in 1952, caused by a single genetic defect.
Camcıoğlu, Yıldız
core   +2 more sources

The European internet-based patient and research database for primary immunodeficiencies: results 2006-2008 [PDF]

, 2009
Primary immunodeficiencies (PID) are rare diseases; therefore transnational studies are essential to maximize the scientific outcome and to improve diagnosis and therapy.
Abuzakouk M., Bangs C., Baumann U., Beauté J., Beauté J., Benslama L., Brodszki N., Caragol I., Ciznar P., Core C., Cucuruz M., Dempster J., Dudoit Y., Dudoit Y., Duobiene R., Exley A., Farber C.M., Fasshauer M., Feighery C., Fischer A., Gathmann B., Goldacker S., Grimbacher B., Hatzistilianou M., Hörnes M., Kanariou M., Kilic S., Kindle G., Knerr V., Knerr V., Kondratenko I., Koren A., Kumararatne D., Kütükcüler N., Litzman J., Llobet P., Lucas M., Mahlaoui N., Marodi L., Marques L., Meyts I., Micol R., Niehues T., Notarangelo L., Papadopoulou Alataki E., Paschenko O., Pasic S., PIGNATA, CLAUDIO, Plebani A., Reda S., Reisli I., Richter D., Ritterbusch H., Sanal O., Savchak I., Shchebet S., Shcherbina A., Soler P., Sollinger F., Stimm H., Szaflarska A., Thon V., Tierney P., Touitou I., Trachana M., Velbri S., Viemann D., Witte T., Wittkowski H., Wolska B., Yegin O.   +70 more
core   +1 more source

Dendritic and T Cell Response to Influenza is Normal in the Patients with X-Linked Agammaglobulinemia [PDF]

, 2011
Introduction Influenza virus is a potential cause of severe disease in the immunocompromised. X-linked agammaglobu-linemia (XLA) is a primary immunodeficiency characterized by the lack of immunoglobulin, B cells, and plasma cells, secondary to mutation ...
A Amedei, A Plebani, AD Crockard, AM Zeman, C Kinnon, D Rastogi, D Vetrie, DJ Rawlings, E Liu, F Rosa Di, FE Lund, G Qin, H Mao, H Taneichi, J Bayry, J Zheng, J Zheng, J Zheng, JS Peiris, K Sochorova, Kwok-Tai Lam, M Paroli, M Terajima, MC Gagliardi, ME Conley, MM Epstein, NJ Horwood, NW Schmidt, P Gray, Pamela Pui-Wah Lee, PJ Linton, PP Lee, W Tu, W Tu, W Tu, Wenwei Tu, XS He, Y Kawakami, Yinping Liu, YL Lau, Yu-Lung Lau, Yuet Wu   +41 more
core   +3 more sources

COVID-19 and X-linked agammaglobulinemia (XLA) - insights from a monogenic antibody deficiency [PDF]

, 2021
Purpose of review The clinical outcomes from COVID-19 in monogenic causes of predominant antibody deficiency have pivotal implications for our understanding of the antiviral contribution of humoral immunity.
Gennery, Andrew R., Humphreys, Ian R., Jolles, Stephen, Ponsford, Mark J., Shillitoe, Benjamin M.J.   +4 more
core   +1 more source

Primary immunodeficiency in Hong Kong and the use of genetic analysis for diagnosis [PDF]

, 2005
Objectives. To review the management of primary immunodeficiency and discuss recent advances in genetic analysis. Design. Retrospective study. Setting. University teaching hospital, Hong Kong. Patients.
Chan, KW, Ho, HK, Lam, DST, Lau, YL, Lee, TL   +4 more
core