Expression and regulation of antimicrobial peptides in mucosal immunity [PDF]
, 2012 Antimicrobial polypeptides (AMPs) are effector molecules of the innate immune defense. AMPs are mainly expressed in epithelial cells and immune cells, providing the first line of defense to infection as direct antimicrobials.
Cederlund, Andreas
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Recurrent pneumonia with mild hypogammaglobulinemia diagnosed as X-linked agammaglobulinemia in adults [PDF]
, 2001 Background X-linked agammaglobulinemia (XLA) is a humoral immunodeficiency caused by disruption of the Bruton's tyrosine kinase (BTK) gene. Typical XLA patients suffer recurrent and severe bacterial infections in childhood.
Hagiwara, Koichi +7 more
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The physical health and quality of life of patients with X-linked agammaglobulinaemia in England and Wales [PDF]
, 2020 Ph. D. Thesis.Background Patients with X-linked agammaglobulinaemia (XLA) have absent peripheral circulating Blymphocytes and agammaglobulinaemia caused by defects in BTK. Treatment consists of life-long immunoglobulin replacement therapy.
Shillitoe, Benjamin Martin James
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B lymphocytes as effector cells in the immunotherapy of cancer [PDF]
, 2011 Over the years, the role of B cells in the host immune response to malignancy has been overshadowed by our focus on T cells. Nevertheless, B cells play important roles as antigen‐presenting cells and in the production of antibodies.
Chang, Alfred E. +8 more
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Gene editing in haematopoietic stem cells for the treatment of X-Linked Agammaglobulinaemia [PDF]
This project was a pre-clinical feasibility study to design a gene editing strategy for X-Linked Agammaglobulinaemia (XLA). This affects roughly 1 in 250,000 births and is caused by a mutation in the BTK gene.
Bahal, Sameer
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Molecular studies on Burton's tyrosine kinase [PDF]
, 1999 X-Linked agammaglobulinaemia (XLA) is a humoral immunodeficiency resulting from a block in the B cell maturation pathway at the pre-B cell stage. Affected males have normal numbers of pre-B cells in the bone marrow but virtually no mature B cells in the ...
Gaspar, Hubert Baburaj
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A Case of Fabry's Disease with Congenital Agammaglobulinemia [PDF]
, 2011 Fabry's disease is an X-linked lysosomal storage disorder caused by abnormalities in the α-galactosidase A (GLA) gene, which leads to a GLA deficiency and to the intracellular deposition of globotriaosylceramide (Gb3) within vascular endothelium and ...
Bernstein +22 more
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Recurrent infections in a five year old boy [PDF]
, 2014 Children are prone to develop recurrent illness in the form of upper respiratory tract infections, gastroenteritis, pustulosis and otitis media owing to developing immunity and environmental exposures.
Goyal , S, Goyal, V
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Expression of Bruton's tyrosine kinase gene and endoplasmic reticulum stress sensors in X-linked agammaglobulinemia [PDF]
, 2018 Orientador: Maria Marluce dos Santos VilelaTese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências MédicasResumo: A agamaglobulinemia ligada ao X (XLA; OMIM#300755) é caracterizada por um bloqueio na diferenciação dos linfócitos B na ...
Ramalho, Vanessa Domingues, 1985-
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Functional interaction between CD180 Toll-like receptor (TLR) and B cell receptor (BCR) in the biology of Chronic Lymphocytic Leukaemia (CLL) [PDF]
, 2017 Chronic Lymphocytic Leukaemia (CLL) is the most common leukaemia in the western world and remains incurable. It is driven by as yet unknown (auto)antigens via the B cell receptor (BCR) and growth, survival and expansion signals it receives from the ...
Rajakaruna, A., Rajakaruna, A.
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