Functional interaction between CD180 Toll-like receptor (TLR) and B cell receptor (BCR) in the biology of Chronic Lymphocytic Leukaemia (CLL) [PDF]
, 2017 Chronic Lymphocytic Leukaemia (CLL) is the most common leukaemia in the western world and remains incurable. It is driven by as yet unknown (auto)antigens via the B cell receptor (BCR) and growth, survival and expansion signals it receives from the ...
Rajakaruna, A., Rajakaruna, A.
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The physical health and quality of life of patients with X-linked agammaglobulinaemia in England and Wales [PDF]
, 2020 Ph. D. Thesis.Background Patients with X-linked agammaglobulinaemia (XLA) have absent peripheral circulating Blymphocytes and agammaglobulinaemia caused by defects in BTK. Treatment consists of life-long immunoglobulin replacement therapy.
Shillitoe, Benjamin Martin James
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Gene editing in haematopoietic stem cells for the treatment of X-Linked Agammaglobulinaemia [PDF]
This project was a pre-clinical feasibility study to design a gene editing strategy for X-Linked Agammaglobulinaemia (XLA). This affects roughly 1 in 250,000 births and is caused by a mutation in the BTK gene.
Bahal, Sameer
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STUDIO COMPUTAZIONALE DI VIRTUAL SCREENING PER LO SVILUPPO DI NUOVI INBITORI DELLA CHINASI BTK [PDF]
, 2014 La BTK (Bruton’s Tyrosine Kinase) è un membro della famiglia delle tirosine chinasi TEC. La BTK è espressa in molte cellule ematopoietiche come linfociti B, nei mastociti, e nei macrofagi, ma non è espressa a livello dei linfociti T, nelle cellule ...
PICCINNO, MARIA ELEONORA
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Recurrent infections in a five year old boy [PDF]
, 2014 Children are prone to develop recurrent illness in the form of upper respiratory tract infections, gastroenteritis, pustulosis and otitis media owing to developing immunity and environmental exposures.
Goyal , S, Goyal, V
core +1 more source
Expression of Bruton's tyrosine kinase gene and endoplasmic reticulum stress sensors in X-linked agammaglobulinemia [PDF]
, 2018 Orientador: Maria Marluce dos Santos VilelaTese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências MédicasResumo: A agamaglobulinemia ligada ao X (XLA; OMIM#300755) é caracterizada por um bloqueio na diferenciação dos linfócitos B na ...
Ramalho, Vanessa Domingues, 1985-
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Btk Regulated Macrophage Polarization in Response to Lipopolysaccharide [PDF]
, 2014 Bacterial Lipopolysaccharide (LPS) is a strong inducer of inflammation and does so by inducing polarization of macrophages to the classic inflammatory M1 population.
Brennan, Kiva +7 more
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Mutations in topoisomerase IIβ result in a B cell immunodeficiency. [PDF]
, 2019 B cell development is a highly regulated process involving multiple differentiation steps, yet many details regarding this pathway remain unknown. Sequencing of patients with B cell-restricted immunodeficiency reveals autosomal dominant mutations in ...
Austin, Caroline A +22 more
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A novel mutation leading to a deletion in the SH3 domain of Bruton's tyrosine kinase [PDF]
, 2006 X-linked agammaglobulinemia (XLA) is a primary B cell immunodeficiency disorder, caused by a defect in the Bruton tyrosine kinase (BTK) gene. Here, we describe a novel four base pair mutation (838delGAGT) in intron 9 of the BTK gene leading to the ...
Fügen Ersoy +5 more
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Bruton's Agammaglobulinemia: Case Series and Literature Review From King Fahad Central Hospital, Jizan, Saudi Arabia. [PDF]
Am J Case RepShamakhi A +7 more
europepmc +1 more source