Results 21 to 30 of about 138,715 (220)

Age-related macular degeneration

Nature Reviews Disease Primers, 2021
Age-related macular degeneration (AMD) is the leading cause of legal blindness in the industrialized world. AMD is characterized by accumulation of extracellular deposits, namely drusen, along with progressive degeneration of photoreceptors and adjacent tissues.
Monika Fleckenstein, Tiarnán D. L. Keenan, Robyn H. Guymer, Usha Chakravarthy, Steffen Schmitz-Valckenberg, Caroline C. Klaver, Wai T. Wong, Emily Y. Chew   +7 more
  +10 more sources

Age-Related Macular Degeneration and Circadian Preference [PDF]

Clinical Ophthalmology
Estefany Garces,1 Katarzyna Slota,2 Michael W Stewart,3 Maria P Guzman,4 Natalia M Werninck,1 Pablo R Castillo1 1Division of Pulmonary, Allergy and Sleep Medicine, Mayo Clinic College of Medicine and Science, Jacksonville, FL, USA; 2Northwest Community ...
Garces E, Slota K, Stewart MW, Guzman MP, Werninck NM, Castillo PR   +5 more
doaj   +2 more sources

Age-related macular degeneration [PDF]

Journal of the Royal Society of Medicine, 2009
Age-related macular degeneration (AMD) is a significant source of morbidity in aging adults. The damage to the macula and vision loss in advanced forms of wet AMD stems from choroidal neovascularization that originates in the choroid and proliferates through breaks in the Bruch membrane. Although inhibitors of angiogenesis have been a recent advance in
Tariq, Ayoub, Nishal, Patel
  +6 more sources

Statins for age-related macular degeneration [PDF]

Cochrane Database of Systematic Reviews, 2008
Age-related macular degeneration (AMD) is a progressive late onset disorder of the macula affecting central vision. Age-related macular degeneration is the leading cause of blindness in people over 65 years in industrialized countries (Congdon 2003). Recent epidemiologic, genetic and pathological evidence has shown AMD shares a number of risk factors ...
Peter L. Gehlbach, Tianjing Li, Elham Hatef   +2 more
openaire   +8 more sources

Age-related macular degeneration [PDF]

The Lancet, 2008
Age-related macular degeneration is the leading cause of blindness in elderly populations of European descent. The most consistent risk factors associated with this ocular condition are increasing age and cigarette smoking. Genetic investigations have shown that complement factor H, a regulator of the alternative complement pathway, and LOC387715/HtrA1
Hanna R, Coleman, Chi-Chao, Chan, Frederick L, Ferris, Emily Y, Chew   +3 more
openaire   +4 more sources

Non-invasive testing for early detection of neovascular macular degeneration in unaffected second eyes of older adults: EDNA diagnostic accuracy study [PDF]

, 2022
Background Neovascular age-related macular degeneration is a leading cause of sight loss, and early detection and treatment is important. For patients with neovascular age-related macular degeneration in one eye, it is usual practice to monitor the ...
Azuara-Blanco, Augusto, Banister, Katie, Chakravarthy, Usha, Cook, Jonathan A, Goulão, Beatriz, Heimann, Heinrich, Hernández, Rodolfo, Hogg, Ruth, Kennedy, Charlotte, Ramsay, Craig, Scotland, Graham, Sivaprasad, Sobha   +11 more
core   +2 more sources

Y chromosome mosaicism is associated with age-related macular degeneration [PDF]

, 2019
Acknowledgements The authors thank Sudha K. Iyengar, Rob Igo and Alberto H. Santana (Case Western Reserve University, Cleveland, Ohio, USA) as well as the IAMDGC (http://eaglep.case.edu/iamdgc_web/) for providing the raw probe intensities.
on behalf of the International Age-related Macular Degeneration Genomics Consortium (IAMDGC)
core   +1 more source

Macular Pigment Optical Density and its Determinants among Adults: A Cross-sectional Study [PDF]

Journal of Clinical and Diagnostic Research, 2021
Introduction: Interplay exists between the risk factors of Agerelated Macular Degeneration (AMD) and the factors influencing Macular Pigment Optical Density (MPOD) level.
POOJA GOYAL, MITASHA SINGH, SHASHI VASHISHTH, SATISH JAYERIA   +3 more
doaj   +1 more source

Complement C3 variant and the risk of age-related macular degeneration [PDF]

, 2007
Background: Age-related macular degeneration is the most common cause of blindness in Western populations. Susceptibility is influenced by age and by genetic and environmental factors.
Armbrecht, AM, Bird, AC, Clayton, DG, Deary, IJ, Dhillon, B, Genetic Factors AMD Study G, Hayward, C, Khan, JC, Matharu, BK, Moore, AT, Morgan, J, Redmond, E, Sepp, T, Shahid, H, Thurlby, DA, Wright, AF, Yates, JRW   +16 more
core   +1 more source

Colour contrast sensitivity in eyes at high risk of neovascular age-related macular degeneration [PDF]

, 2020
Purpose: To generate the first published reference database of colour contrast sensitivity in eyes at high risk of neovascular age-related macular degeneration and to explore this important feature in quality of vision.
Bartlett, Hannah, Calcagni, Antonio, Denniston, Alastair Ko, Eperjesi, Frank, Gibson, Jonathan M, Hogg, Christopher R, Howells, Olivia, Matthews, Timothy D   +7 more
core   +1 more source