Results 51 to 60 of about 93,339 (287)

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

Long-Term Follow-Up of Dry Age-Related Macular Degeneration Patients

Journal of Current Ophthalmology
Purpose: To assess the progression rate from dry age-related macular degeneration (dAMD) to advanced AMD and possible risk factors. Methods: Demographics, medical and ocular conditions, baseline eye examinations, optical coherence tomography features ...
Elham Sadeghi, Golnoush Mahmoudinezhad, Nicola Valsecchi, Sharat Chandra Vupparaboina, Sandeep Chandra Bollepalli, Kiran Kumar Vupparaboina, Jose-Alain Sahel, Andrew W. Eller, Jay Chhablani   +8 more
doaj   +1 more source

Structural basis for complement factor H-linked age-related macular degeneration

, 2007
Nearly 50 million people worldwide suffer from age-related macular degeneration (AMD), which causes severe loss of central vision. A single-nucleotide polymorphism in the gene for the complement regulator factor H (FH), which causes a Tyr-to-His ...
Pietro Roversi, Clark, S, Robert B. Sim, Susan M. Lea, Jowitt, Thomas A., Beverly E. Prosser, Prosser, Beverly E., Prosser, B, Day, Anthony J., Herbert, AP, Dušan Uhrín, Sim, Robert B., Uhrin, Dusan, Barlow, P, Johnson, S, Lea, SM, Steven Johnson, Blaum, Barbel S., Barlow, Paul N., Herbert, A, Barlow, PN, Sim, RB, Simon J. Clark, Roversi, P, Uhrín, D, Johnson, Steven, Thomas A. Jowitt, Day, A, Jowitt, Thomas A.; id_orcid, Edward Tarelli, Jess Tyrrell, Lea, Susan M., Tyrrell, J, Blaum, BS, Herbert, Andrew P., Clark, Simon J., Tyrrell, Jess, Day, Anthony J.; id_orcid, Lea, Susan, Tarelli, E, Clark, SJ, Paul N. Barlow, Bärbel S. Blaum, Clark, Simon; id_orcid, Tarelli, Edward, Prosser, BE, Jowitt, TA, Day, AJ, Andrew P. Herbert, Roversi, Pietro, Anthony J. Day   +50 more
core   +1 more source

Micronutrients in Age-Related Macular Degeneration [PDF]

Ophthalmologica, 2012
Several lines of evidence from in vitro and in vivo studies suggest that specific micronutrients may have beneficial effects in age-related macular degeneration (AMD). Such effects appear to be complex and may include filtering short wavelength light and attenuating oxidative and inflammatory damage as well as other structural and physiological factors.
Aslam, Tariq; id_orcid 0000-0002-9739-7280, Delcourt, Cécile, Silva, Rufino, Holz, Frank G., Leys, Anita, Garcià Layana, Alfredo, Souied, Eric   +6 more
openaire   +3 more sources

ORBIT‐AMD: Ordinal Risk, Bilateral Imaging, and Trajectory Learning for Age‐Related Macular Degeneration in Multi‐Cohorts

Advanced Science, EarlyView.
Eligibility flow and real‐world AMD burden in the UKB retinal imaging cohort and TMUEH external‐validation cohort. Overview of the ORBIT‐AMD architecture, integrating retinal representation pretraining, bilateral eye‐graph modeling and concept bottleneck learning to support ordered risk, bilateral context, interpretable lesion concepts, longitudinal ...
Xuehao Cui, Dejia Wen, Patrick Yu‐Wai‐Man, Xiaorong Li   +3 more
wiley   +1 more source

Pharmacogenetics and Age-Related Macular Degeneration

Journal of Ophthalmology, 2011
Pharmacogenetics seeks to explain interpatient variability in response to medications by investigating genotype-phenotype correlations. There is a small but growing body of data regarding the pharmacogenetics of both nonexudative and exudative age ...
Stephen G. Schwartz, Milam A. Brantley
doaj   +1 more source

Biological effects of cigarette smoke in cultured human retinal pigment epithelial cells. [PDF]

, 2012
The goal of the present study was to determine whether treatment with cigarette smoke extract (CSE) induces cell loss, cellular senescence, and extracellular matrix (ECM) synthesis in primary human retinal pigment epithelial (RPE) cells. Primary cultured
Johannes Burger, Yu, Alice L., Burger, Johannes, Welge-Lussen, Ulrich, Alice L Yu, Kerstin Birke, Birke, Kerstin, Alice L. Yu, Ulrich Welge-Lussen   +8 more
core   +1 more source

Age-related macular degeneration [PDF]

Postgraduate Medical Journal, 1998
Summary Macular degeneration is now responsible for approximately 95% of blindness and partial sighted registrations in the UK. This review has been written specifically to make the general medical community of the UK aware of the prevalence and clinical manifestations of aged-related macular degeneration. The review encompasses the risk
openaire   +2 more sources

Macular pigment and age related macular degeneration [PDF]

British Journal of Ophthalmology, 1999
The yellow coloration of the macula lutea is attributable to the presence of macular pigment in the axons of its photoreceptors.1 In the 1980s several investigators demonstrated that macular pigment consists of the xanthophyll isomers, lutein and zeaxanthin.2 3 Although the role of the macular pigment remains uncertain, several functions have been ...
Beatty, S., Boulton, M., Henson, D., Koh, H. H., Murray, I. J.   +4 more
openaire   +3 more sources

Retinal Vessel Segmentation: A Comprehensive Review From Classical Methods to Deep Learning Advances (1982–2025)

Advanced Intelligent Systems, EarlyView.
Four decades of retinal vessel segmentation research (1982–2025) are synthesized, spanning classical image processing, machine learning, and deep learning paradigms. A meta‐analysis of 428 studies establishes a unified taxonomy and highlights performance trends, generalization capabilities, and clinical relevance.
Avinash Bansal, Jan Kubíček, Jana Bahrová, Alice Varyšová, Martin Augustýnek, Marek Penhaker, Juraj Timkovič   +6 more
wiley   +1 more source