Results 71 to 80 of about 2,022,626 (303)
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Dopamine restores reward prediction errors in old age. [PDF]
, 2013 Senescence affects the ability to utilize information about the likelihood of rewards for optimal decision-making. Using functional magnetic resonance imaging in humans, we found that healthy older adults had an abnormal signature of expected value ...
Chowdhury, R +6 more
core +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Deep Learning and Multiplex Networks for Accurate Modeling of Brain Age
Frontiers in Aging Neuroscience, 2019 Recent works have extensively investigated the possibility to predict brain aging from T1-weighted MRI brain scans. The main purposes of these studies are the investigation of subject-specific aging mechanisms and the development of accurate models for ...
Nicola Amoroso +14 more
doaj +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
LSTGINet: Local Attention Spatio-Temporal Graph Inference Network for Age Prediction
AlgorithmsThere is a close correlation between brain aging and age. However, traditional neural networks cannot fully capture the potential correlation between age and brain aging due to the limited receptive field.
Yi Lei +7 more
doaj +1 more source
Towards Automated Performance Bug Identification in Python
, 2016 Context: Software performance is a critical non-functional requirement, appearing in many fields such as mission critical applications, financial, and real time systems.
Mazzawi, Elie +2 more
core +1 more source
Trauma Early Mortality Prediction Tool (TEMPT) for assessing 28-day mortality. [PDF]
, 2018 Background:Prior mortality prediction models have incorporated severity of anatomic injury quantified by Abbreviated Injury Severity Score (AIS). Using a prospective cohort, a new score independent of AIS was developed using clinical and laboratory ...
Callcut, Rachael A +3 more
core +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source