Results 11 to 20 of about 474,048 (356)

cGAS–STING drives ageing-related inflammation and neurodegeneration

Nature, 2023
The cGAS–STING signalling pathway is a critical driver of chronic inflammation and functional decline during ageing, and could be targeted to halt neurodegenerative processes during old age.
M. F. Gulen, Natasha Samson, Alexander Keller, Marius Schwabenland, Chong Liu, S. Glück, Vivek V. Thacker, L. Favre, Bastien Mangeat, Lona J Kroese, P. Krimpenfort, M. Prinz, A. Ablasser   +12 more
semanticscholar   +1 more source

Implementing care for healthy ageing

BMJ Global Health, 2022
The WHO concept of Healthy Ageing (ie, the process of developing and maintaining the functional ability that enables well-being in older age) has initiated a global discussion about the need for shifting paradigms to reorient health and social services ...
Anshu Banerjee, Yuka Sumi, Matteo Cesari, Andrew Briggs, Hyobum Jang, Ritu Sadana, Jotheeswaran Amuthavalli Thiyagarajan, Zee A Han, Monica Perracini   +8 more
doaj   +1 more source

Ageing threatens sustainability of smallholder farming in China

Nature, 2023
Rapid demographic ageing substantially affects socioeconomic development^ 1 – 4 and presents considerable challenges for food security and agricultural sustainability^ 5 – 8 , which have so far not been well understood. Here, by using data from more than
Chenchen Ren, Xinyue Zhou, Chen Wang, Yaolin Guo, Yu Diao, Sisi Shen, Stefan Reis, Wanyue Li, Jianming Xu, Baojing Gu   +9 more
semanticscholar   +1 more source

Regulation of the one carbon folate cycle as a shared metabolic signature of longevity

Nature Communications, 2021
Metabolic pathways are closely intertwined with longevity. Here the authors perform metabolomic profiling of canonical longevity pathways and show that folate and methionine cycle intermediates are changed in common, and further, genetic manipulation of ...
Andrea Annibal, Rebecca George Tharyan, Maribel Fides Schonewolff, Hannah Tam, Christian Latza, Markus Max Karl Auler, Adam Antebi   +6 more
doaj   +1 more source

Mapping the use of patient reported outcomes at a health organisation to inform integration into hospital data systems.

International Journal of Population Data Science, 2022
Objectives Incorporating patient reported outcomes into health data linkage research ensures that the patient’s perspective is considered. We aimed to understand the use of patient reported outcomes across an entire healthcare organisation, to inform ...
David Snowdon, Velandai Srikanth, Lucy Marsh, Richard Beare, Emily Parker, Nadine Andrew   +5 more
doaj   +1 more source

Correction: Who Lives Where and Does It Matter? Changes in the Health Profiles of Older People Living in Long Term Care and the Community over Two Decades in a High Income Country.

PLoS ONE, 2016
[This corrects the article DOI: 10.1371/journal.pone.0161705.].
Cognitive Function and Ageing Studies (DFAS)
doaj   +1 more source

Aging [PDF]

Korean Journal of Audiology, 2013
Aging is initiated based on genetic and environmental factors that operate from the time of birth of organisms. Aging induces physiological phenomena such as reduction of cell counts, deterioration of tissue proteins, tissue atrophy, a decrease of the metabolic rate, reduction of body fluids, and calcium metabolism abnormalities, with final progression
Park, Dong Choon, Yeo, Seung Geun
openaire   +2 more sources

Comprehensive measurement of stroke gait characteristics with a single accelerometer in the laboratory and community: a feasibility, validity and reliability study

Journal of NeuroEngineering and Rehabilitation, 2017
Background Application of objective measurement of stroke gait with accelerometer-based wearable technology and associated algorithms is increasing, despite reports questioning the accuracy of this technique in quantifying specific stroke-related gait ...
Sarah A. Moore, Aodhan Hickey, Sue Lord, Silvia Del Din, Alan Godfrey, Lynn Rochester   +5 more
doaj   +1 more source

The gut microbiome as a modulator of healthy ageing

Nature reviews: Gastroenterology & hepatology, 2022
The gut microbiome is a contributory factor in ageing-related health loss and in several non-communicable diseases in all age groups. Some age-linked and disease-linked compositional and functional changes overlap, while others are distinct.
T. Ghosh, F. Shanahan, P. O’Toole
semanticscholar   +1 more source

A multidimensional systems biology analysis of cellular senescence in aging and disease

Genome Biology, 2020
Background Cellular senescence, a permanent state of replicative arrest in otherwise proliferating cells, is a hallmark of aging and has been linked to aging-related diseases.
Roberto A. Avelar, Javier Gómez Ortega, Robi Tacutu, Eleanor J. Tyler, Dominic Bennett, Paolo Binetti, Arie Budovsky, Kasit Chatsirisupachai, Emily Johnson, Alex Murray, Samuel Shields, Daniela Tejada-Martinez, Daniel Thornton, Vadim E. Fraifeld, Cleo L. Bishop, João Pedro de Magalhães   +15 more
doaj   +1 more source