Results 21 to 30 of about 474,048 (356)

Repeat length of C9orf72-associated glycine–alanine polypeptides affects their toxicity

Acta Neuropathologica Communications, 2023
G4C2 hexanucleotide repeat expansions in a non-coding region of the C9orf72 gene are the most common cause of familial amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).
Javier Morón-Oset, Lilly Katharina Sophie Fischer, Nathalie Jauré, Pingze Zhang, Annika Julia Jahn, Tessa Supèr, André Pahl, Adrian M. Isaacs, Sebastian Grönke, Linda Partridge   +9 more
doaj   +1 more source

Feedback between p21 and reactive oxygen production is necessary for cell senescence

Molecular Systems Biology, 2010
Cellular senescence—the permanent arrest of cycling in normally proliferating cells such as fibroblasts—contributes both to age‐related loss of mammalian tissue homeostasis and acts as a tumour suppressor mechanism.
João F Passos, Glyn Nelson, Chunfang Wang, Torsten Richter, Cedric Simillion, Carole J Proctor, Satomi Miwa, Sharon Olijslagers, Jennifer Hallinan, Anil Wipat, Gabriele Saretzki, Karl Lenhard Rudolph, Tom B L Kirkwood, Thomas von Zglinicki   +13 more
doaj   +1 more source

Balancing the struggle to live with dementia: a systematic meta-synthesis of coping

BMC Geriatrics, 2019
Background People with dementia describe experiences of loss that threaten their autonomy and ability to contribute to society. They often have difficulties with orientation, loss of roll function, and fear about the future, and need help from others. An
Guro Hanevold Bjørkløf, Anne-Sofie Helvik, Tanja Louise Ibsen, Elisabeth Wiken Telenius, Ellen Karine Grov, Siren Eriksen   +5 more
doaj   +1 more source

The ENJOY MAP for HEALTH: Exercise interveNtion outdoor proJect in the cOmmunitY for older people—More Active People for HEALTHier communities: a study protocol

BMC Public Health, 2022
Background Physical activity is important to maintain health in older age, with physical activity in the outdoors providing mental and physical health benefits for all age groups.
Pazit Levinger, Jeremy Dunn, Emma Abfalter, Briony Dow, Frances Batchelor, Stephanie Garratt, Neil T Diamond, Keith D. Hill   +7 more
doaj   +1 more source

The Expression and Function of Metastases Associated Lung Adenocarcinoma Transcript-1 Long Non-Coding RNA in Subchondral Bone and Osteoblasts from Patients with Osteoarthritis

Cells, 2021
Metastasis Associated Lung Adenocarcinoma Transcript-1 (MALAT1) is implicated in regulating the inflammatory response and in the pathology of several chronic inflammatory diseases, including osteoarthritis (OA).
Fawzeyah A. Alnajjar, Archana Sharma-Oates, Susanne N. Wijesinghe, Hussein Farah, Dominika E. Nanus, Tom Nicholson, Edward T. Davis, Simon W. Jones   +7 more
doaj   +1 more source

The longitudinal progression of autonomic dysfunction in Parkinson's disease: A 7-year study

Frontiers in Neurology, 2023
BackgroundAutonomic dysfunction, including gastrointestinal, cardiovascular, and urinary dysfunction, is often present in early Parkinson's Disease (PD). However, the knowledge of the longitudinal progression of these symptoms, and the connection between
Charlotte B. Stewart, David Ledingham, Victoria K. Foster, Kirstie N. Anderson, Sahana Sathyanarayana, Debra Galley, Nicola Pavese, Nicola Pavese, Jacopo Pasquini, Jacopo Pasquini   +9 more
doaj   +1 more source

Plant-Derived Antioxidants: Significance in Skin Health and the Ageing Process

International Journal of Molecular Sciences, 2022
Natural substances have traditionally been used in skin care for centuries. There is now an ongoing search for new natural bioactives that not only promote skin health but also protect the skin against various harmful factors, including ultraviolet ...
M. Michalak
semanticscholar   +1 more source

Oxidative Stress in Ageing and Chronic Degenerative Pathologies: Molecular Mechanisms Involved in Counteracting Oxidative Stress and Chronic Inflammation

International Journal of Molecular Sciences, 2022
Ageing and chronic degenerative pathologies demonstrate the shared characteristics of high bioavailability of reactive oxygen species (ROS) and oxidative stress, chronic/persistent inflammation, glycation, and mitochondrial abnormalities.
Thobekile S Leyane, S. W. Jere, N. Houreld   +2 more
semanticscholar   +1 more source

Ageing and vascular ageing [PDF]

Postgraduate Medical Journal, 2006
Abstract There is an age related decline in various physiological processes. Vascular ageing is associated with changes in the mechanical and the structural properties of the vascular wall, which leads to the loss of arterial elasticity and reduced arterial compliance.
B, Jani, C, Rajkumar
openaire   +2 more sources

MARK-AGE biomarkers of ageing [PDF]

Mechanisms of Ageing and Development, 2015
Many candidate biomarkers of human ageing have been proposed in the scientific literature but in all cases their variability in cross-sectional studies is considerable, and therefore no single measurement has proven to serve a useful marker to determine, on its own, biological age.
Bürkle, Alexander, Moreno Villanueva, María, Bernhard, Jürgen, Blasco, María, Zondag, Gerben, Hoeijmakers, Jan H. J., Toussaint, Olivier, Grubeck Loebenstein, Beatrix, Mocchegiani, Eugenio, Collino, Sebastiano, Gonos, Efstathios S., Sikora, Ewa, Gradinaru, Daniela, Dollé, Martijn, Salmon, Michel, Kristensen, Peter, Griffiths, Helen R., Libert, Claude, Grune, Tilman, Breusing, Nicolle, Simm, Andreas, FRANCESCHI, CLAUDIO, CAPRI, MIRIAM, Talbot, Duncan, Caiafa, Paola, Friguet, Bertrand, Slagboom, P. Eline, Hervonen, Antti, Hurme, Mikko, Aspinall, Richard   +29 more
openaire   +6 more sources