Results 21 to 30 of about 52,982 (221)
Innovation in AgingAbstract Objective indicators of cognitive decline, immune function and inflammation are used as objective markers of aging (OMAs) to predict an individuals aging success. Individuals beliefs and evaluations of their own age and aging, like subjective age have been found to significantly impact longevity and health in old age, making ...
Selovin, Fabio +3 more
openaire +2 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Allogeneic hematopoietic stem cell transplantation (alloHSCT) is an essential therapy for several malignant and nonmalignant diseases, but relapse and graft loss remain the principal threats to its success. Routine monitoring of chimerism and minimal residual disease (MRD) enables early detection of imminent recurrence and guides ...
Carmen Junk +10 more
wiley +1 more source
Metabolic and Genetic Markers of Biological Age [PDF]
Frontiers in Genetics, 2017 Biological age is a concept that takes into account the heterogeneity of the aging process in different individuals that results in differences in survival and variations in relative health. Any measure of biological age must be better than chronological age at predicting mortality.
Jazwinski, S. Michal, Kim, Sangkyu
openaire +3 more sources
Pediatric Idiopathic Multicentric Castleman Disease Is Often Severe But Responsive to Siltuximab
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Idiopathic multicentric Castleman disease (iMCD) is a potentially fatal immunologic disorder marked by widespread lymphadenopathy and inflammation. Siltuximab, an interleukin‐6 (IL‐6) inhibitor, is the only FDA‐approved treatment for adult patients with iMCD.
Bridget Austin +17 more
wiley +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Numerous international studies have reported declines in new cancer diagnoses, delayed diagnoses and disruptions in cancer treatment following the implementation of COVID‐19 pandemic public health measures, raising concerns that these effects may ultimately contribute to increased cancer mortality.
Friederike Erdmann +8 more
wiley +1 more source
Biological Age is a Universal Marker of Aging, Stress, and Frailty [PDF]
, 2019 Summary We carried out a systematic investigation of supervised learning techniques for biological age modeling. The biological aging acceleration is associated with the remaining health- and life-span. Artificial Deep Neural Networks (DNN) could be used to reduce the error of chronological age predictors, though often at the expense of
Pyrkov, Timothy V., Fedichev, Peter O.
openaire +1 more source
BACH2: A marker of DNA damage and ageing [PDF]
DNA Repair, 2013 DNA damage and ageing share expression changes involving alterations in many aspects of metabolism, suppression of growth and upregulation of defence and genome maintenance systems. "Omics" technologies have permitted large-scale parallel measurements covering global cellular constituents and aided the identification of specific response pathways that ...
Uittenboogaard L. M. +7 more
openaire +2 more sources
Inflammatory marker trajectories associated with frailty and ageing in a 20‐year longitudinal study
Clinical & Translational Immunology, 2022 Objective The aim of this exploratory study was to investigate the development of low‐grade inflammation during ageing and its relationship with frailty.
Leonard Daniël Samson +6 more
doaj +1 more source
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Background Therapeutic apheresis (TA) is an established treatment modality for hematologic, neurologic, and immunologic disorders, yet access remains severely limited in sub‐Saharan Africa. Donor apheresis, including platelet apheresis collection from healthy donors, represents an important complementary modality supporting blood product ...
Nosa Bazuaye +33 more
wiley +1 more source
Income and Markers of Immunological Cellular Aging [PDF]
Psychosomatic Medicine, 2016 ABSTRACTObjectiveSocioeconomic disadvantage may contribute to poor health through immune-related biological mechanisms. We examined the associations between socioeconomic status, as measured by annual household income, and T-cell markers of aging, including the ratios of CD4 and CD8 effector cells to naïve cells (E/N ratio) and the CD4/CD8 T-cell ratio.
Allison E, Aiello +8 more
openaire +3 more sources