Results 11 to 20 of about 50,207 (142)

Endocrine markers of aging [PDF]

Experimental Gerontology, 1988
Sophisticated methods available to quantitate hormone secretion and hormone action provide opportunities to identify potential endocrine biomarkers of aging. However, there are many challenges facing the investigator who wishes to establish an endocrine biomarker.
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Revisiting the Hallmarks of Aging to Identify Markers of Biological Age [PDF]

The Journal of Prevention of Alzheimer's Disease, 2020
The Geroscience aims at a better understanding of the biological processes of aging, to prevent and/or delay the onset of chronic diseases and disability as well as to reduce the severity of these adverse clinical outcomes. Geroscience thus open up new perspectives of care to live a healthy aging, that is to say without dependency.
Guerville, Florent, de Souto Barreto, Philipe, Ader, I., Andrieu, Sandrine, Casteilla, L., Dray, C., Fazilleau, Nicolas, Guyonnet, Sophie, Langin, D., Liblau, Roland, Parini, A., Valet, P., Vergnolle, Nathalie, Rolland, Yves, Vellas, Bruno   +14 more
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Malondialdehyde: A Possible Marker of Ageing

Gerontology, 2002
<i>Background:</i> Numerous recent studies have suggested that oxidative damage may be important in the ageing process, and lipid peroxidation is an important biological consequence of oxidative cellular damage. <i>Objective:</i> The aim of this work was to analyze the activities of the two protective enzymes, superoxide ...
Gil, P., Fariñas, F., Casado Moragón, Ángela, López-Fernández, M.E.   +3 more
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The Role of BDNF on Aging-Modulation Markers [PDF]

Brain Sciences, 2020
An important link between brain aging and a class of growth/survival factors called neurotrophins has recently been demonstrated. In particular, brain-derived neurotrophic factor (BDNF) plays a fundamental role during age-related synaptic loss, preventing cerebral atrophy and cognitive decline.
Claudio Molinari, Vera Morsanuto, Sara Ruga, Felice Notte, Mahitab Farghali, Rebecca Galla, Francesca Uberti   +6 more
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Metabolomics in aging research: aging markers from organs

Frontiers in Cell and Developmental Biology, 2023
Metabolism plays an important role in regulating aging at several levels, and metabolic reprogramming is the main driving force of aging. Due to the different metabolic needs of different tissues, the change trend of metabolites during aging in different organs and the influence of different levels of metabolites on organ function are also different ...
Weicheng Fang, Shuxin Chen, Xuejiao Jin, Shenkui Liu, Xiuling Cao, Beidong Liu, Beidong Liu   +6 more
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Income and Markers of Immunological Cellular Aging [PDF]

Psychosomatic Medicine, 2016
ABSTRACTObjectiveSocioeconomic disadvantage may contribute to poor health through immune-related biological mechanisms. We examined the associations between socioeconomic status, as measured by annual household income, and T-cell markers of aging, including the ratios of CD4 and CD8 effector cells to naïve cells (E/N ratio) and the CD4/CD8 T-cell ratio.
Allison E, Aiello, Lydia, Feinstein, Jennifer B, Dowd, Graham, Pawelec, Evelyna, Derhovanessian, Sandro, Galea, Monica, Uddin, Derek E, Wildman, Amanda M, Simanek   +8 more
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Fluctuation of the Fibrosis Markers with Aging.

Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics, 2002
Actual age and biological age are not always proportional. To find out indices of aging, other than actual age, we investigated relationship between aging and four hepatic fibrosis markers: hyaluronates, type IV collagen, type IV collagen 7s and P III P. The subject of this study were 78 patients of inpatients and outpatients of our hospital. They were
Eto, Nao, Yoshino, Junji, Inui, Kazuo, Wakabayashi, Takao, Okushima, Kazumu, Kobayashi, Takashi, Miyoshi, Hironao   +6 more
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Metabolic and Genetic Markers of Biological Age [PDF]

Frontiers in Genetics, 2017
Biological age is a concept that takes into account the heterogeneity of the aging process in different individuals that results in differences in survival and variations in relative health. Any measure of biological age must be better than chronological age at predicting mortality.
Jazwinski, S. Michal, Kim, Sangkyu
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Biological Age is a Universal Marker of Aging, Stress, and Frailty [PDF]

, 2019
Summary We carried out a systematic investigation of supervised learning techniques for biological age modeling. The biological aging acceleration is associated with the remaining health- and life-span. Artificial Deep Neural Networks (DNN) could be used to reduce the error of chronological age predictors, though often at the expense of
Pyrkov, Timothy V., Fedichev, Peter O.
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γH2AX as a molecular marker of aging and disease [PDF]

Epigenetics, 2010
Double-strand breaks are one of the most critical DNA lesions with respect to cell-death and preservation of genomic integrity. Rapid phosphorylation of the histone variant H2AX at Ser-139 to form gammaH2AX is an early cellular response to DNA double-strand breaks.
Li-Jeen, Mah, Assam, El-Osta, Tom C, Karagiannis   +2 more
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