Results 71 to 80 of about 431,918 (275)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

"So go downtown": simulating pedestrian movement in town centres [PDF]

, 2001
Pedestrian movement models have been developed since the 1970s. A review of the literature shows that such models have been developed to explain and predict macro, meso, and micro movement patterns.
Haklay, M, O'Sullivan, D, Schelhorn, T, Thurstain-Goodwin, M   +3 more
core   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Integrating artificial intelligence with mechanistic epidemiological modeling: a scoping review of opportunities and challenges

Nature Communications
Integrating prior epidemiological knowledge embedded within mechanistic models with the data-mining capabilities of artificial intelligence (AI) offers transformative potential for epidemiological modeling.
Yang Ye, Abhishek Pandey, Carolyn Bawden, Dewan Md. Sumsuzzman, Rimpi Rajput, Affan Shoukat, Burton H. Singer, Seyed M. Moghadas, Alison P. Galvani   +8 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

The mimosa generic modelling and simulation platform : The case of multi-agent systems [PDF]

, 2004
The aim of this paper is to introduce Mimosa: a generic platform for modelling and simulation and to show its applicability to the specification of multi-agent simulations based on the AGR (Agent-Group-Role) model.
Müller, Jean Pierre
core  

Agent-based modelling in synthetic biology [PDF]

, 2016
Biological systems exhibit complex behaviours that emerge at many different levels of organization. These span the regulation of gene expression within single cells to the use of quorum sensing to co-ordinate the action of entire bacterial colonies ...
Gorochowski, Thomas E
core   +4 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Integrating evolution into ecological modelling: accommodating phenotypic changes in agent based models. [PDF]

, 2013
PMCID: PMC3733718This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited ...
A Grafen, A Grafen, AA Hoffmann, AJ van Noordwijk, Aristides Moustakas, B Matthews, BEC Lyon, C Both, C Parmesan, C Zheng, CM Perrins, D Eisinger, G-R Walther, HQP Crick, JE Brommer, JMJ Travis, JR Bridle, JS Clark, Jérémie Bourdon, K Schiffers, LR Lawlor, M Begon, Matthew R. Evans, ME Visser, MJ Mustard, MR Evans, MR Evans, MT Ghiselin, NG Hairston, P Medawar, PA Abrams, PR Moorcroft, R Lande, RAG-C Stillman, RH McCleery, S Descamps, S Verhulst, SP Ellner, SW Pacala, T Coulson, T Coulson, T Day, TG Benton, THG Ezard, TJ Givnish, V Grimm, WJ Sutherland, WJ Sutherland, YG Matsinos   +48 more
core   +3 more sources