Results 111 to 120 of about 1,605,329 (295)
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard +5 more
wiley +1 more source
InterfasesEl desarrollo de arquitecturas agénticas de inteligencia artificial (IA) ha dado lugar a nuevos modelos de interacción y automatización, entre los que destacan los flujos de trabajo basados en agentes de IA (agentic workflows) y la comunicación entre ...
Olda Bustillos Ortega +4 more
doaj +1 more source
Raciocínio adaptativo de base emocional em agentes inteligentes [PDF]
, 2005 O projecto e implementação de agentes inteligentes capazes de comportamento eficaz em ambientes reais, onde a incerteza e o dinamismo são generalizados e onde tempo e recursos são limitados, levanta problemas importantes, relacionados quer com a ...
Gaspar, Graça, Morgado, Luís
core
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Women from Santiago: Invisible or Invisibilized?
Santiago, 2016 In spite of the advance experienced in the last years, the research about female participation in the independent struggle results insifficient and demand a deepening in local researches This present work, has objective to give some dates related with ...
Damaris Amparo Torres-Eler
doaj
Agents, agent architectures and multi-agent systems
, 2010 M.Sc. The use of computer systems has changed over the years. Modern computer systems operate in an environment that is open, distributed and heterogeneous. They have the capability of locating information stored in remote locations and satisfying the interests and objectives of different users.
openaire +1 more source
El presente artículo pretende mostrar al lector el amplio abanico de posibilidades que ofrecen los materiales compuestos en el campo de la ingeniería y el diseño.
Castejón, Luis, Miravete, Antonio
core
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source