Results 131 to 140 of about 1,605,329 (295)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
La desregulación de la comercialización de electricidad en Inglaterra y Gales [PDF]
A partir de 1995, las autoridades regulatorias de Reino Unido han comenzado un proceso de introducción de competencia para ventas minoristas de electricidad.
Romero, Carlos A.
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Agentes tutor e estilos de aprendizagem em ambientes adaptativos [PDF]
, 2008 O Processo de Bolonha que pretende mudar o paradigma educativo passando a estar centrado no aluno, é um dos maiores desafios que o ensino superior enfrenta actualmente.
Alves, Paulo
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Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Fasciolosis humana diagnosticada en fase aguda. Primer reporte clínico en México
Revista de Gastroenterología de México, 2016 O.R. Cruz y López +4 more
doaj +1 more source
Metodología para el Desarrollo Automatizado de Aplicaciones Seguras Basadas en Agentes Móviles [PDF]
, 2006 En este trabajo presentamos una metodología para el diseño de aplicaciones basadas en agentes móviles seguros, y unas herramientas para aplicar esta metodología.
Garrigues Olivella, Carles +2 more
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ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
A Política pública do turismo e o turismo social [PDF]
, 2012 Em 2009, o turismo foi erigido pelo XVII Governo Constitucional português como uma política pública, em virtude da adoção no seu programa o turismo como uma área de intervenção prioritária, tendo em conta a crescente importância do turismo na economia ...
Patrício, Manuela
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Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
CAB-O-SIL .......instant agent ... agent... agent [PDF]
Chemical & Engineering News Archive, 1960 openaire +1 more source