Results 101 to 110 of about 1,841,120 (284)

Effect of bioactive compounds from Cornus mas L. fruits on the level of advanced glycation end-products (AGEs) and receptors for ages in blood plasma and leukocytes of rats with streptozotocin-induced diabetes mellitus

Біологічні студії
Background. Мetabolic distortions mediated сhronic hyperglycemia lead to pathophysiological alterations in diabetes mellitus. Persistent elevation of blood glucose promotes non-enzymatic glycation of proteins and lipids, leading to the accumulation of ...
Iryna Brodyak, Nataliia Sybirna
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Ageing through the Ages

Journal of the Royal College of Physicians of Edinburgh, 1999
MacLennan, W. J., Sellers, W. I.; id_orcid 0000-0002-2913-5406   +1 more
openaire   +3 more sources

Beyond the Kannisto-Thatcher Database on Old Age Mortality: an assessment of data quality at advanced ages [PDF]

The old age population in developed countries has been increasing remarkably, yet internationally comparable high quality data on oldest-old mortality remain relatively scarce.
Dmitri A. Jdanov, Eugeny L. Soroko, James W. Vaupel, Domantas Jasilionis, Roland Rau   +4 more
core  

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Tea Polyphenols Protect the Blood–Brain Barrier Structure in the Hippocampus of Early Diabetic Mice by Inhibiting the AGEs–RAGE Pathway

Journal of Integrative Neuroscience
Background: Diabetic encephalopathy is a prevalent complication of diabetes mellitus, which is primarily characterized by hippocampal injury and blood-brain barrier (BBB) dysfunction.
Zhiyong Xu, Yan Liu, Yan Yu
doaj   +1 more source

Childhood through the ages

, 2013
This chapter examines different historical interpretations of childhood and identifies and evaluates some of the salient themes and forms of discourse that have surrounded the major traditions of research into childhood.
Valkanova, D.
core  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Childhood through the ages

, 2017
This chapter examines different historical interpretations of childhood and identifies and evaluates some of the salient themes and forms of discourse that have surrounded the major traditions of research into childhood.
Valkanova, D.
core  

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source