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Stem cell-based strategies for intervertebral disc regeneration in degenerative microenvironments: challenges and solutions. [PDF]

Front Cell Dev Biol
Wang H, Xu A, Hua W, Mao J, Zhang J, Ma X, Lu L.   +6 more
europepmc   +1 more source

NAT10-mediated ac4C modification of KDM1B drives osteoarthritis progression through epigenetic suppression of SOX9. [PDF]

Cell Mol Life Sci
Chen S, Ou W, Li X, Jie M, Zheng Y, Situ J, Liao Z, Huang L, Qi W, Ni S.   +9 more
europepmc   +1 more source

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Aggrecan, aging and assembly in articular cartilage

Cellular and Molecular Life Sciences, 2005
The primary function of articular cartilage to act as a self-renewing, low frictional material that can distribute load efficiently at joints is critically dependent upon the composition and organisation of the extracellular matrix. Aggrecan is a major component of the extracellular matrix, forming high molecular weight aggregates necessary for the ...
Jayesh Dudhia
exaly   +3 more sources

Decorin Regulates the Aggrecan Network Integrity and Biomechanical Functions of Cartilage Extracellular Matrix

ACS Nano, 2019
Joint biomechanical functions rely on the integrity of cartilage extracellular matrix. Understanding the molecular activities that govern cartilage matrix assembly is critical for developing effective cartilage regeneration strategies.
Biao Han, Hadi T Nia, Christopher Li
exaly   +2 more sources

Aggrecan and versican: two brothers close or apart.

American Journal of Physiology - Cell Physiology, 2022
Aggrecan (Acan) and versican (Vcan) are large chondroitin sulfate proteoglycans of the extracellular matrix. They share the same structural domains at both N and C-termini.
H. Watanabe
semanticscholar   +1 more source

Aggrecan and chondroitin-6-sulfate abnormalities in schizophrenia and bipolar disorder: a postmortem study on the amygdala

Translational Psychiatry, 2015
Perineuronal nets (PNNs) are specialized extracellular matrix aggregates surrounding distinct neuronal populations and regulating synaptic functions and plasticity.
Sabina Berretta
exaly   +2 more sources

Aggrecan Nanoscale Solid–Fluid Interactions Are a Primary Determinant of Cartilage Dynamic Mechanical Properties

ACS Nano, 2015
Hadi Tavakoli Nia, Lin Han, Iman Soltani Bozchalooi   +2 more
exaly   +2 more sources

An Enzyme‐Sensitive PEG Hydrogel Based on Aggrecan Catabolism for Cartilage Tissue Engineering

Advanced Healthcare Materials, 2015
Stacey C Skaalure, Stanley Chu, Stephanie J Bryant   +2 more
exaly   +2 more sources

Aggrecan in bovine tendon

Matrix Biology, 1994
Large proteoglycans were purified by ion-exchange chromatography, gel filtration and CsCl gradient centrifugation from the compressed and tensional regions of adult bovine deep flexor tendon. Tryptic peptide maps of proteoglycan from the compressed region were very similar to maps of aggrecan from bovine articular cartilage, with evidence for the ...
K G, Vogel, J D, Sandy, G, Pogány, J R, Robbins   +3 more
openaire   +2 more sources

Aggrecan from start to finish

Journal of Bone and Mineral Metabolism, 2000
terminal globular (G)1 domain and a C-terminal G3 domain that are joined by intervening nonglobular sequences of lengths characteristic for each core protein. In addition, the aggrecan core protein has a G2 domain. The G1, G2, and G3 domains each contain distinctive motifs, with each motif having its own folded structure (Fig. 1).
W, Luo, C, Guo, J, Zheng, T L, Chen, P Y, Wang, B M, Vertel, M L, Tanzer   +6 more
openaire   +2 more sources