Results 61 to 70 of about 642,146 (342)
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Collation of the results of the 2014 aggregate minerals survey for England and Wales [PDF]
, 2016 1.1 Aggregate Minerals (AM) surveys, normally undertaken at four-yearly intervals since 1973, provide an in-depth and up-to-date understanding of national and sub-national sales, inter-regional flows, transportation, consumption and permitted reserves
Bide, T.P. +4 more
core
The contribution of ecological footprinting to planning policy development: using REAP to evaluate policies for sustainable housing construction [PDF]
, 2008 The complexity of the sustainable-development policy goal is such that policy makers are searching for tools to enable them to evaluate and develop policy directions.
Nye, M, Rydin, Y
core +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Modeling an aggregate production planning
, 2022 This paper aims to present and discuss the benefits that small- and medium-sized companies can get when using mathematical programming to help in the decision-making process regarding aggregate production planning. The aggregate plan is concerned with determining the quantity of a good or a family of goods to be produced and also scheduling its ...
Zanella, Fernando, Vaz, Clara B.
openaire +2 more sources
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Greenhouse Gases, Cooperation, and Exchange [PDF]
, 2001 Emission of uniformly dispersed greenhouse gases is construed here as a cooperative production game, featuring side-payments, quota exchange, uncertainty, and multi-period planning.
Flam, S.D.
core
Mathematical Problems in Engineering, 2019 In this paper, we study the aggregate production planning problem for vegetables within the framework of uncertainty theory. In detail, preservation technology investment is taken into consideration to reduce the deterioration rate and improve the ...
Yufu Ning, Na Pang, Xiao Wang
semanticscholar +1 more source
Molecular Oncology, EarlyView.To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley +1 more source