Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
MathematicsThis paper proposes an icon-based methodology for the design of prototype aggregated production planning software that addresses the complexity of multi-process and multi-product production. Aggregate planning is a critical task in production management,
Erick Miranda-Meza +2 more
doaj +1 more source
Model Penunjang Keputusan Jadwal Produksi Jus Buah Segar
Jurnal Teknik Industri, 2012 Planning and production control are important factors to determine the efficiency derived through proper management of raw material supply of fresh fruits, production planning and master production schedule.
Iffan Maflahah +2 more
doaj +1 more source
Desining a Multi-Objective Mathematical Model of Cumulative Production Planning in Reverse Supply Chain With Production Quality Function Under Uncertainty and Using MPSOGA Tran-Innovation Algorithm (High-Tech Industry Case Study) [PDF]
مدیریت مهندسی و رایانش نرم, 2023 In the present paper, the cogeneration program in the form of an inverse supply chain using multi-objective mathematical modeling in conditions of uncertainty is considered.
Saeid Rezaie Moghadam, Aslan Doosti
doaj
Collation of the results of the 2014 aggregate minerals survey for England and Wales [PDF]
, 2016 1.1 Aggregate Minerals (AM) surveys, normally undertaken at four-yearly intervals since 1973, provide an in-depth and up-to-date understanding of national and sub-national sales, inter-regional flows, transportation, consumption and permitted reserves
Bide, T.P. +4 more
core
Environmental sustainability in the mining sector: evidence from Catalan companies [PDF]
, 2014 This paper examines the adoption of environmental practices in small and medium sized companies inthe surface mining industry in Catalonia (Spain). To fulfill this aim, a survey of 41 items concernint environmental management systems and environmentally ...
Freijo Álvarez, Modesto +2 more
core +3 more sources
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Solving Fuzzy Multiproduct Aggregate Production Planning Problems Based on Extension Principle
International Journal of Mathematics and Mathematical Sciences, 2014 Aggregate production planning (APP) plays a critical role in supply chain management (SCM). This paper investigates multiproduct, multiperiod APP problems with several distinct types of fuzzy uncertainties.
Shih-Pin Chen, Wen-Lung Huang
doaj +1 more source
Greenhouse Gases, Cooperation, and Exchange [PDF]
, 2001 Emission of uniformly dispersed greenhouse gases is construed here as a cooperative production game, featuring side-payments, quota exchange, uncertainty, and multi-period planning.
Flam, S.D.
core
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source