Results 21 to 30 of about 12,311,713 (381)

Aging and age‐related diseases: from mechanisms to therapeutic strategies

Biogerontology (Dordrecht), 2021
Aging is a physiological process mediated by numerous biological and genetic pathways, which are directly linked to lifespan and are a driving force for all age-related diseases.
Zhe Li, Zhenkun Zhang, Yikun Ren, Yingying Wang, Jiarui Fang, Han Yue, Shanshan Ma, F. Guan   +7 more
semanticscholar   +1 more source

Double-Blind Placebo-Controlled Pilot Investigation of the Safety of a Single Dose of Rapid-Acting Intranasal Insulin in Down Syndrome

Drugs in R&D, 2020
Background Individuals with Down syndrome are likely to develop clinical and neuropathological brain changes resembling Alzheimer’s disease dementia by the ages of 35–40 years.
Michael Rosenbloom, Terry Barclay, Justin Johnsen, Lauren Erickson, Aleta Svitak, Maria Pyle, William Frey, Leah R. Hanson   +7 more
doaj   +1 more source

Cell-Type Specific Changes in Glial Morphology and Glucocorticoid Expression During Stress and Aging in the Medial Prefrontal Cortex. [PDF]

, 2018
Repeated exposure to stressors is known to produce large-scale remodeling of neurons within the prefrontal cortex (PFC). Recent work suggests stress-related forms of structural plasticity can interact with aging to drive distinct patterns of pyramidal ...
Bruce S. McEwen, Dani Dumitriu, Erik B. Bloss, John H. Morrison, John H. Morrison, Thomas E. Chan, Wendy Lou, William G. Janssen, Yael S. Grossman   +8 more
core   +2 more sources

Effects of an Unusual Poison Identify a Lifespan Role for Topoisomerase 2 in Saccharomyces Cerevisiae [PDF]

, 2017
A progressive loss of genome maintenance has been implicated as both a cause and consequence of aging. Here we present evidence supporting the hypothesis that an age-associated decay in genome maintenance promotes aging in Saccharomyces cerevisiae (yeast)
Baxter, Bonnie, Gilbertson, Matthew, Goldfarb, David S., Madrey, Joe, Millen, Jonathan, Nitiss, John L., Piazza, Gary A., Polevoda, Bogdan, Rapaport, Matan, Rasmussen, Lynn, Tombline, Gregory, Van Meter, Michael, Wennerberg, Kirster, White, E. Lucile   +13 more
core   +2 more sources

Non cell autonomous upregulation of CDKN2 transcription linked to progression of chronic hepatitis C disease [PDF]

, 2013
Chronic hepatitis C virus infection (C-HC) is associated with higher mortality arising from hepatic and extrahepatic disease. This may be due to accelerated biological aging; however, studies in C-HC have thus far been based solely on telomere length as ...
Barclay, Stephen, McGuinness, Dagmara, McLauchlan, John, Mills, Peter R., Patel, Arvind H., Robinson, Mark W., Shiels, Paul G., Swann, Rachael   +7 more
core   +2 more sources

Ageing and vascular ageing [PDF]

Postgraduate Medical Journal, 2006
Abstract There is an age related decline in various physiological processes. Vascular ageing is associated with changes in the mechanical and the structural properties of the vascular wall, which leads to the loss of arterial elasticity and reduced arterial compliance.
B, Jani, C, Rajkumar
openaire   +2 more sources

The Role of Inflammation after Surgery for Elders (RISE) study: Study design, procedures, and cohort profile

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2019
Introduction The Role of Inflammation after Surgery for Elders study correlates novel inflammatory markers measured in blood, cerebrospinal fluid (CSF) assays, and [11C]‐PBR28 positron‐emission tomography imaging.
Tammy T. Hshieh, Sarinnapha M. Vasunilashorn, Madeline L. D'Aquila, Steven E. Arnold, Bradford C. Dickerson, Tamara G. Fong, Richard N. Jones, Edward R. Marcantonio, Eva M. Schmitt, Guoquan Xu, Yun Gou, Fan Chen, Lisa J. Kunze, Kamen V. Vlassakov, Ayesha R. Abdeen, Jeffrey K. Lange, Brandon E. Earp, Alexandra Touroutoglou, Becky C. Carlyle, Pia Kivisakk‐Webb, Thomas G. Travison, Simon T. Dillon, Towia A. Libermann, Sharon K. Inouye, RISE Study Group, Sharon K. Inouye, Steven Arnold, Bradford Dickerson, Tamara Fong, Richard Jones, Towia A. Libermann, Edward R. Marcantonio, Thomas Travison, Becky C. Carlyle, Michele Cavallari, Simon T. Dillon, Jacob Hooker, Tammy Hshieh, Savannah Kandigian, Pia Kivisakk‐Webb, Long Ngo, Hasan Otu, Eva M. Schmitt, Alexandra Touroutoglou, Bianca Trombetta, Sarinnapha Vasunilashorn, Ayesha Abdeen, Douglas Ayres, Brandon Earp, Jeffrey Lange, Gregory Brick, Antonia Chen, Robert Davis, Jacob Drew, Richard Iorio, Fulton Kornack, Michael Weaver, Anthony Webber, Richard Wilk, Lisa Kunze, David Shaff, Kamen Vlassakov, Brett Armstrong, Angelee Banda, Sylvie Bertrand, Madeline D'Aquila, Jacqueline Gallagher, Baileigh Hightower, Shannon Malloy, Jacqueline Nee, Chloe Nobuhara, Abigail Overstreet, Annie Racine, David Urick, Guoquan Xu, Grae Arabasz, Michael Brickhouse, Regan Butterfield, Shirley Hsu, Sara Makaretz, Judit Sore, Fan Chen, Yun Gou, Douglas Tommet, Sabrina Carretie, Ted Gruen, Katherine Tasker   +86 more
doaj   +1 more source

Regulation of the mitochondrial transition pore : impact on mammalian aging [PDF]

, 2011
Commentary on: Hafner AV et al. Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 suppresses age-related cardiac hypertrophy. Aging.
Osiewacz, Heinz D.
core   +2 more sources

MARK-AGE biomarkers of ageing [PDF]

Mechanisms of Ageing and Development, 2015
Many candidate biomarkers of human ageing have been proposed in the scientific literature but in all cases their variability in cross-sectional studies is considerable, and therefore no single measurement has proven to serve a useful marker to determine, on its own, biological age.
Bürkle, Alexander, Moreno Villanueva, María, Bernhard, Jürgen, Blasco, María, Zondag, Gerben, Hoeijmakers, Jan H. J., Toussaint, Olivier, Grubeck Loebenstein, Beatrix, Mocchegiani, Eugenio, Collino, Sebastiano, Gonos, Efstathios S., Sikora, Ewa, Gradinaru, Daniela, Dollé, Martijn, Salmon, Michel, Kristensen, Peter, Griffiths, Helen R., Libert, Claude, Grune, Tilman, Breusing, Nicolle, Simm, Andreas, FRANCESCHI, CLAUDIO, CAPRI, MIRIAM, Talbot, Duncan, Caiafa, Paola, Friguet, Bertrand, Slagboom, P. Eline, Hervonen, Antti, Hurme, Mikko, Aspinall, Richard   +29 more
openaire   +6 more sources

Aging after shear rejuvenation in a soft glassy colloidal suspension: evidence for two different regimes

, 2006
The aging dynamics after shear rejuvenation in a glassy, charged clay suspension have been investigated through dynamic light scattering (DLS). Two different aging regimes are observed: one is attained if the sample is rejuvenated before its gelation and
B. Berne, F. Ianni, G. Ruocco, H. Van Olphen, R. Di Leonardo, R. G. Larson, S. Gentilini   +6 more
core   +1 more source