Results 171 to 180 of about 512,073 (249)

Non‐steroidal antiandrogens act as AF‐1 agonists under conditions of high androgen‐receptor expression [PDF]

, 2007
Hiroaki Fuse, Shigeru Korenaga, Matomo Sakari, Takashi Hiyama, Takeshi Ito, Kôichi Kimura, Shigeaki Kato   +6 more
openalex   +1 more source

Genetically‐Programmed Hypervesiculation of Lactiplantibacillus Plantarum Increases Production of Bacterial Extracellular Vesicles with Therapeutic Efficacy in a Preclinical Inflammatory Bowel Disease Model

Advanced Science, EarlyView.
The development of a novel engineered strain of Lactiplantibacillus plantarum (Lp) is reported that can produce bacterial extracellular vesicles (BEVs) at >60‐fold higher yields than the unmodified parental strain. These Lp BEVs retain therapeutic bioactivity as validated in a mouse model of dextran sodium sulfate‐induced colitis.
Nicholas H Pirolli, Daniel Levy, Alyssa Schledwitz, Natalia Sampaio Moura, Mitali Sarkar, Talia J. Solomon, Emily H. Powsner, Raith Nowak, Zuzanna Mamczarz, Christopher J. Bridgeman, Sulayman Khan, Andrew Hui, Nidhi Anne, Laura Reus, William E. Bentley, Jean‐Pierre Raufman, Steven M. Jay   +16 more
wiley   +1 more source

Editorial Comment on: Use and Persistence of Beta-3 Adrenoceptor Agonists for the Treatment of Overactive Bladder. [PDF]

Int J Urol
Mochizuki T.
europepmc   +1 more source

TRIM38 Suppresses Breast Cancer Progression via Modulating SQSTM1 Ubiquitination and Autophagic Flux

Advanced Science, EarlyView.
TRIM38, an E3 ubiquitin ligase, suppresses breast cancer progression by inhibiting proliferation, migration, and invasion. Downregulated in breast tumor, its loss correlates with poor prognosis. Mechanistically, TRIM38 mediates K63‐linked ubiquitination of SQSTM1/p62 at K420, disrupting SQSTM1‐LC3 interaction and blocking autophagic flux.
Shan Jiang, Lijuan Wang, Dianwen Han, Peng Su, Bing Chen, Wenjing Zhao, Tong Chen, Ning Zhang, Xiaolong Wang, Yiran Liang, Yaming Li, Chen Li, Xi Chen, Dan Luo, Qifeng Yang   +14 more
wiley   +1 more source

Multi-faceted roles of β-arrestins in G protein-coupled receptor endocytosis. [PDF]

Nat Commun
Liu J, Xue L, Ravier MA, Eshak F, Acher FC, Goupil-Lamy A, Cimadevila M, Drube J, Hoffmann C, Inoue A, Trinquet E, Dupuis E, Prézeau L, Pin JP, Rondard P.   +14 more
europepmc   +1 more source

Synthesis and structure–activity relationship of 3-arylbenzoxazines as selective estrogen receptor β agonists

, 2004
Wu Yang, Yufeng Wang, Zhengping Ma, Rajasree Golla, Terry R. Stouch, Ramakrishna Seethala, Susan E. Johnson, Rong Zhou, Timur Güngör, Jean H.M. Feyen, John K. Dickson   +10 more
openalex   +1 more source

Hepatocyte Mettl3 Deficiency Drives Primary Sclerosing Cholangitis and Liver Fibrosis via Cholangiocyte‐Macrophage Crosstalk

Advanced Science, EarlyView.
Schematic illustration demonstrating that hepatic Mettl3 depletion significantly elevates the secretion of Mif and Csf1. This elevation facilitates Trem2+ macrophage infiltration and triggers cholangiocyte remodeling through the Spp1‐Cd44 interaction, resulting in spontaneous PSC development in vivo.
Wenting Pan, Yuting Yong, Yuanshuai Li, Gaona Shi, Min Zhang, Lingfei Wan, Yue Zhao, Wenling Zhan, Yanli Lin, Qiaozhen Qin, Xupeng Chen, Yanli Ni, Haixu Chen, Wenzai Shi, Xiaomeng Guo, Juan Chen, Shuchen Liu, Youliang Wang, Bing Liu, Xinlong Yan   +19 more
wiley   +1 more source

Inducible T-Cell Co-Stimulator (ICOS) and ICOS Ligand: Dealing With a Two-Faced Cancer Immunoregulatory System. [PDF]

Cancer Med
Nikanjam M, Kato S, Nishizaki D, Miyashita H, Pabla S, Nesline MK, Ko H, Conroy JM, Naing A, Kurzrock R.   +9 more
europepmc   +1 more source

Truncation of the peptide sequence in bifunctional ligands with mu and delta opioid receptor agonist and neurokinin 1 receptor antagonist activities

, 2013
Padma Nair, Takashi Yamamoto, Tally M. Largent‐Milnes, Scott Cowell, Vinod Kulkarni, Sharif Moye, Edita Navratilova, Peg Davis, Shou-wu Ma, Todd W. Vanderah, Josephine Lai, Frank Porreca, Victor J. Hruby   +12 more
openalex   +1 more source

Unraveling the Morphological and Functional Maturation Mechanisms Underlying Human Neural Development Using iPSCs‐Derived Neuronal Model

Advanced Science, EarlyView.
Using human induced pluripotent stem cells (hiPSCs)‐derived neuronal model, Tian and colleagues reveal that voltage‐gated calcium channels Cav1.2 and Cav1.3, and their mediated calcium ion influx, are essential for early morphogenesis of human neuronal development, while ECEL1 underlies human neuronal functional developmental maturation through CALM3 ...
Yue Tian, Yi‐Chun Ou, Zi‐Xian Zhang, Jie Cai, Si‐Qing Cai, Guo‐Gang Xing   +5 more
wiley   +1 more source