Results 11 to 20 of about 1,083,474 (317)

Recent advances in cancer immunotherapy: Modulation of tumor microenvironment by Toll-like receptor ligands [PDF]

BioImpacts, 2022
Immunotherapy is considered a promising approach for cancer treatment. An important strategy for cancer immunotherapy is the use of cancer vaccines, which have been widely used for cancer treatment.
Leila Rostamizadeh, Ommoleila Molavi, Mohsen Rashid, Fatemeh Ramazani, Behzad Baradaran, Afsaneh Lavasanaifar, Raymond Lai   +6 more
doaj   +1 more source

Functional GLP-1R antibodies identified from a synthetic GPCR-focused library demonstrate potent blood glucose control

mAbs, 2021
G protein-coupled receptors (GPCRs) are a group of seven-transmembrane receptor proteins that have proven to be successful drug targets. Antibodies are becoming an increasingly promising modality to target these receptors due to their unique properties ...
Qiang Liu, Pankaj Garg, Burcu Hasdemir, Linya Wang, Emily Tuscano, Emily Sever, Erica Keane, Ana G Lujan Hernandez, Tom Z. Yuan, Eric Kwan, Joyce Lai, Greg Szot, Sreenivasan Paruthiyil, Fumiko Axelrod, Aaron K. Sato   +14 more
doaj   +1 more source

Avatrombopag for the treatment of thrombocytopenia induced by chemotherapy in patients with solid tumors: A multicenter, open-label, single-arm trial

Frontiers in Pharmacology, 2022
Objective: To explore the effect and safety of avatrombopag for chemotherapy-induced thrombocytopenia (CIT).Methods: This multicenter, open-label, single-arm trial enrolled CIT patients in eight centers from October 2020 to April 2021.
Yayun Cui, Yifu He, Changlu Hu, Congyin Tu, Jin Huang, Xiaofeng Zhu, Chunbao Zang, Kaiyang Ding, Bihong Zhan, Yufei Zhao, Liting Qian   +10 more
doaj   +1 more source

Prolonged activation of innate immune pathways by a polyvalent STING agonist

Nature Biomedical Engineering, 2021
The stimulator of interferon genes (STING) is an endoplasmic reticulum transmembrane protein that is a target of therapeutics for infectious diseases and cancer.
Suxin Li, Min Luo, Zhaohui Wang, Q. Feng, Jonathan Wilhelm, Xu Wang, Wei Li, Jian Wang, Agnieszka Cholka, yang-xin fu, B. Sumer, Hongtao Yu, Jinming Gao   +12 more
semanticscholar   +1 more source

Structures of active-state orexin receptor 2 rationalize peptide and small-molecule agonist recognition and receptor activation

Nature Communications, 2021
Narcolepsy type 1 (NT1) is a chronic neurological disorder that impairs the brain’s ability to control sleep-wake cycles. Current therapies are limited to the management of symptoms with modest effectiveness and substantial adverse effects.
C. Hong, N. Byrne, B. Zamlynny, S. Tummala, Li Xiao, J. Shipman, A. Partridge, C. Minnick, M. Breslin, M. Rudd, S. Stachel, V. Rada, J. Kern, K. Armacost, S. Hollingsworth, J. O'brien, D. Hall, T. Mcdonald, C. Strickland, A. Brooun, S. Soisson, K. Hollenstein   +21 more
semanticscholar   +1 more source

Nikotinski acetilholinski receptor kot farmakološka tarča pri pljučnem raku

Acta Biologica Slovenica, 2022
Rak pljuč je zelo razširjena oblika raka z nizko stopnjo preživetja. Kajenje tobaka predstavlja glavni dejavnik tveganja za razvoj raka pljuč, saj v tobačnem dimu najdemo veliko rakotvornih snovi.
Veno Kononenko, Tadeja Bele, Sara Novak, Igor Križaj, Damjana Drobne, Tom Turk   +5 more
doaj   +1 more source

On agonistic memory [PDF]

Memory Studies, 2016
Building on Mouffe’s critique of cosmopolitanism, this article argues that a cosmopolitan mode of remembering, far from having superseded the antagonistic mode associated with ‘first modernity’ in the European context, has proved unable to prevent the rise of, and is being increasingly challenged by, new antagonistic collective memories constructed by
Cento Bull, Anna, Hansen, Hans Lauge
openaire   +2 more sources

CD40 Agonist Antibodies in Cancer Immunotherapy.

Annual Review of Medicine, 2020
CD40 is a cell-surface member of the TNF (tumor necrosis factor) receptor superfamily. Upon activation, CD40 can license dendritic cells to promote antitumor T cell activation and re-educate macrophages to destroy tumor stroma.
R. Vonderheide
semanticscholar   +1 more source

Lithium amplifies agonist-dependent phosphatidylinositol responses in brain and salivary glands [PDF]

Biochemical Journal, 1982
1. The effect of Li+ on the agonist-dependent metabolism of [3H]inositol has been studied in rat brain, rat parotid and the insect salivary gland. 2. When brain or parotid slices were incubated in the presence of [3H]inositol, Li+ was found to amplify ...
Michael J. Berridge, C. Peter Downes, Michael R. Hanley   +2 more
openalex   +2 more sources

Conductance increases produced by bath application of cholinergic agonists to Electrophorus electroplaques [PDF]

, 1975
When solutions containing agonists are applied to the innervated face of an Electrophorus electroplaque, the membrane's conductance increases. The agonist-induced conductance is increased at more negative membrane potentials.
Changeux, Jean-Pierre, Lester, Henry A., Sheridan, Robert E.   +2 more
core   +7 more sources