Prolonged activation of innate immune pathways by a polyvalent STING agonist
Nature Biomedical Engineering, 2021 The stimulator of interferon genes (STING) is an endoplasmic reticulum transmembrane protein that is a target of therapeutics for infectious diseases and cancer.
Suxin Li +12 more
semanticscholar +1 more source
Doubles-agonistes, tri-agonistes et multi-agonistes incrétines/glucagon
Médecine des Maladies Métaboliques, 2021 Resume L’innovation pharmacologique en diabetologie est un veritable defi. La nouvelle famille des co-agonistes des recepteurs GIP/GLP-1 represente une avancee therapeutique importante pour ameliorer la prise en charge du diabete de type 2 (DT2). L’activation des deux recepteurs incretines peut avoir des effets metaboliques additifs en comparaison a ...
Phan, Franck, Andreelli, Fabrizio
openaire +3 more sources
Memory Studies, 2016 Building on Mouffe’s critique of cosmopolitanism, this article argues that a cosmopolitan mode of remembering, far from having superseded the antagonistic mode associated with ‘first modernity’ in the European context, has proved unable to prevent the rise of, and is being increasingly challenged by, new antagonistic collective memories constructed by
Cento Bull, Anna, Hansen, Hans Lauge
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CD40 Agonist Antibodies in Cancer Immunotherapy.
Annual Review of Medicine, 2020 CD40 is a cell-surface member of the TNF (tumor necrosis factor) receptor superfamily. Upon activation, CD40 can license dendritic cells to promote antitumor T cell activation and re-educate macrophages to destroy tumor stroma.
R. Vonderheide
semanticscholar +1 more source
Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist
JCI Insight, 2020 Tirzepatide (LY3298176) is a dual GIP and GLP-1 receptor agonist under development for the treatment of type 2 diabetes mellitus (T2DM), obesity, and nonalcoholic steatohepatitis.
F. Willard +17 more
semanticscholar +1 more source
Lithium amplifies agonist-dependent phosphatidylinositol responses in brain and salivary glands [PDF]
Biochemical Journal, 1982 Michael J. Berridge +2 more
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Structural Probing and Molecular Modeling of the A3 Adenosine Receptor: A Focus on Agonist Binding
Molecules, 2017 Adenosine is an endogenous modulator exerting its functions through the activation of four adenosine receptor (AR) subtypes, termed A1, A2A, A2B and A3, which belong to the G protein-coupled receptor (GPCR) superfamily.
Antonella Ciancetta, Kenneth A. Jacobson
doaj +1 more source
α1D-Adrenoceptors are responsible for the high sensitivity and the slow time-course of noradrenaline-mediated contraction in conductance arteries [PDF]
, 2013 The objective of this study was to determine whether the different time-course characteristics of α1-adrenoceptor-mediated contraction in arteries can be related to the subtypes involved.
Alexander +53 more
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Novel 2-amino-isoflavones exhibit aryl hydrocarbon receptor agonist or antagonist activity in a species/cell-specific context [PDF]
, 2012 The aryl hydrocarbon receptor (AhR) mediates the induction of a variety of xenobiotic metabolism genes. Activation of the AhR occurs through binding to a group of structurally diverse compounds, most notably dioxins, which are exogenous ligands ...
BALBONI, GIANFRANCO +10 more
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Identification of Two Novel α1-AR Agonists Using a High-Throughput Screening Model
Molecules, 2014 α1-Adrenoceptors (ARs; 1A, 1B, and 1D) have been determined to perform different prominent functions in the physiological responses of the sympathetic nervous system.
Fang Xu +7 more
doaj +1 more source