Results 221 to 230 of about 1,200,697 (382)

Endothelial Cell Organization Drives Distinct Agonist-Specific Ca²⁺ Dynamics in Arteries and Veins. [PDF]

Acta Physiol (Oxf)
Lee MD, Clark RA, Buckley C, Zhang X, Uhlen P, Wilson C, McCarron JG.   +6 more
europepmc   +1 more source

Improving voiding efficiency in the diabetic rat by a 5‐HT1A serotonin receptor agonist [PDF]

, 2011
Baojun Gu, Gang Wu, Jieming Si, Yuemin Xu, Karl‐Erik Andersson   +4 more
openalex   +1 more source

Disruption of NF‐κB‐Mediated Copper Homeostasis Sensitizes Breast Cancer to Cuproptosis

Advanced Science, EarlyView.
This study reveals a feedback mechanism regulating copper homeostasis, in which copper directly interacts with TAK1 to activate NF‐κB signaling, while NF‐κB transcriptionally suppresses copper transporter (CTR1) expression. These findings highlight a promising therapeutic strategy for breast cancer by combining NF‐κB inhibitors with copper chelators or
Xiaomei Zhang, Yaqing Su, Weixiong Yang, Zimin Song, Zicheng Sun, Xueji Wu, Jianwen Chen, Bing Gao, Zekang Wang, Lei Wang, Qiwei Jiang, Lang Bu, Jingting Li, Ying Lin, Wei Xie, Jie Li, Jianping Guo   +16 more
wiley   +1 more source

Letter to the Editor in Response to "Efficacy and Safety of Histamine H3 Receptor Antagonist/Inverse Agonist Including Betahistine for Schizophrenia: A Systematic Review and Meta-Analysis" by Nishii et al. [PDF]

Neuropsychopharmacol Rep
Farhan M.
europepmc   +1 more source

The effect of ovarian stimulation on aneuploidy of early aborted tissues and preimplantation blastocysts: comparison of the GnRH agonist long protocol with the GnRH antagonist protocol

, 2022
Jun Wang, Jing Zhang, Nan Zhao, Yuan Ma, Xiyi Wang, Xingqing Gou, Ying Ju, Hengde Zhang, Shuqiang Chen, Xiaohong Wang   +9 more
openalex   +2 more sources

Adenylosuccinate Synthase 1 Deficiency Improves Energy Metabolism by Promoting Adipose Tissue Re‐esterification via Glycerol Kinase Upregulation

Advanced Science, EarlyView.
Working model of Adss1‐mediated regulation of energy metabolism in adipose tissue. In beige adipocytes, Adss1 interacts with HDAC3 in the cytoplasm, and its loss reduces nuclear HDAC3 while increasing cytosolic fractions. This redistribution suppresses HDAC activity and enhances H3K27 acetylation at the Gk promoter, leading to transcriptional ...
Jingjing Sun, Miriayi Alimujiang, Wenfei Li, Shuqin Chen, Yingying Su, Tingting Hu, Xuhong Lu, Yafen Ye, Ningning Bai, Fan Hu, Xiaoya Li, Rongrong Xu, Jun Xu, Jiarui Zhao, Yan Lu, Xiaojing Ma, Ying Yang   +16 more
wiley   +1 more source

STING agonists trigger monocyte death via apoptosis, pyroptosis, caspase-8 activation and mitochondrial dysfunction. [PDF]

Cell Death Discov
Pimkova Polidarova M, Plecita-Hlavata L, Hirsch I, Grantz Saskova K, Brazdova A.   +4 more
europepmc   +1 more source

Agonist-Mediated Activation of STING Induces Apoptosis in Malignant B Cells.

Cancer Research, 2016
C. Tang, Joseph A. Zundell, Sujeewa Ranatunga, Cindy Lin, Yulia Nefedova, J. D. Del Valle, C. Hu   +6 more
semanticscholar   +1 more source

Modifying Glucose Metabolism Reverses Memory Defects of Alzheimer's Disease Model at Late Stages

Advanced Science, EarlyView.
Using spatial transcriptomics, we show that ferul enanthate (SL‐ZF‐01) reverses episodic‐like memory deficits in aged, but not young, Alzheimer’s disease (AD) mice. SL restores glucose metabolism and Glucose Transporter 1/3 expression via an ‘Aging‐AD‐Rescue’ pattern, rescuing deficits seen in aged AD mice.
Fang Liu, Yiyu‐Li Tang, Zong‐Bo Zhang, Ya‐Hong Tan, Si‐Hui Lin, Ni‐Ya Wang, Jin‐Nan Li, Zhi‐Jie Pan, Jian‐Feng Li, Jing‐Fei Huang, Yu‐Qiang Ding, Chun‐Ming Guo, Lin Xu, Cheng Peng, Qi‐Xin Zhou   +14 more
wiley   +1 more source

Mixed-mechanism analgesics for mixed pain. [PDF]

Front Med (Lausanne)
Raffa RB.
europepmc   +1 more source