Results 251 to 260 of about 1,168,781 (390)

Possible role of distinct morphine and enkephalin receptors in mediating actins of benzomorphan drugs (putative kappa and sigma agonists).

, 1980
K J Chang, Eli Hazum, Pedro Cuatrecasas
openalex   +1 more source

The G Protein–Biased κ-Opioid Receptor Agonist RB-64 Is Analgesic with a Unique Spectrum of Activities In Vivo

Journal of Pharmacology and Experimental Therapeutics, 2015
K. White, J. E. Robinson, Hu Zhu, Jeffrey F. DiBerto, Pr Polepally, J. Zjawiony, D. Nichols, C. Malanga, B. Roth   +8 more
semanticscholar   +1 more source

Long Term High‐Salt Diet Induces Cognitive Impairments via Down‐Regulating SHANK1

Advanced Science, EarlyView.
The study identifies a novel mechanistic link between long‐term HS diet and cognitive impairment, wherein PKA/CREB axis inactivation leads to SHANK1 reduction, synaptic damage, and cognitive deficits. Abstract High‐salt (HS) diet is an established risk factor for cognitive impairment, but the underlying mechanisms remain unclear.
Cuiping Guo, Yuanyuan Li, Wensheng Li, Tongrui Wu, Yi Liu, Yacoubou Abdoul Razak Mahaman, Jianzhi Wang, Rong Liu, Wei Liu, Hui Shen, Xiaochuan Wang   +10 more
wiley   +1 more source

Biased Signaling and Its Role in the Genesis of Short- and Long-Acting β₂-Adrenoceptor Agonists. [PDF]

Biochemistry
Phan NTN, Borrega-Roman L, Hoare BL, Harwood CR, Geary N, Guba W, Han Y, Zenko V, Koers EJ, Rufer AC, Grether U, Veprintsev DB, Sykes DA.   +12 more
europepmc   +1 more source

Multiple actions of β-adrenergic agonists on skeletal muscle and adipose tissue [PDF]

, 1989
Yue Yang, Mary Ann McElligott
openalex   +1 more source

Dopamine D1 Receptor Contributes to Glucocorticoid‐Associated Osteonecrosis of Femoral Head Protection Through the ATF3/CHOP Axis to Inhibit Osteoblastic Apoptosis

Advanced Science, EarlyView.
This work identifies a novel mechanism by which dopamine D1 receptor (DRD1) contributes to the pathogenesis of glucocorticoid (GC)‐associated osteonecrosis of the femoral head (ONFH) through the regulation of osteoblastic apoptosis, indicating that DRD1 serves as a critical mediator of the crosstalk between the nervous and skeletal systems.
Kai Zheng, Wenming Li, Tianhao Wang, Gaoran Ge, Wei Zhang, Yi Qin, Wenhao Li, Zebin Wu, Zhen Wang, Gang Rui, Yaozeng Xu, Dechun Geng   +11 more
wiley   +1 more source

The acute effect of the GABA-agonist, THIP, on proprioceptive and flexor reflexes in spastic patients

, 1983
K. Mondrup, Ejner Pedersen
openalex   +1 more source

Structure of an Agonist-Bound Human A2A Adenosine Receptor

Science, 2011
Fei Xu, Huixian Wu, V. Katritch, G. Han, K. Jacobson, Zhang-Guo Gao, V. Cherezov, R. Stevens   +7 more
semanticscholar   +1 more source

H2O2‐Activated Serotonin Precursor Probe for Mapping Neuronal Redox Homeostasis Reveals 5‐HT Interactions with Neighboring Proteins Under Oxidative Stress

Advanced Science, EarlyView.
HOP, an innovative ICT‐based fluorescent probe, visualizes H2O2 in stressed neurons while locally releasing serotonin (5‐HT) for real‐time protein interaction mapping. Its unique tandem sensing and labeling strategy reveals 5‐HT's role under oxidative stress, offering a powerful tool for neurophysiological research and therapeutic discovery.
Yani Liu, Jiwen Yuan, Tuanjie Zhang, Xinyi Cai, Meng Xu, Xueao Wang, Rui Wang, Bing Zhang, Hai‐Liang Zhu, Yong Qian   +9 more
wiley   +1 more source

Using cocaine and apomorphine self-administration in rats to measure the pharmacokinetics of competitive dopamine receptor antagonists administered by different routes. [PDF]

Sci Rep
Song HJ, Desai JN, Norman MK, Norman AB.
europepmc   +1 more source