Results 251 to 260 of about 1,200,697 (382)

RELATIVE POTENCY OF AGONIST AND PARTIAL AGONIST OPIOIDS

British Journal of Anaesthesia, 1985
openaire   +2 more sources

Morphine Tolerance Gated through EZH2‐Mediated Suppression of Trpc5 in Spinal GABAergic Interneurons in Male Mice

Advanced Science, EarlyView.
Chronic morphine suppresses Trpc5 in spinal GABAergic interneurons via EZH2‐mediated histone modification, reducing Ca2+ influx and GABA release. TRPC5 activation enhances morphine analgesia, while EZH2 inhibition restores efficacy and reverses tolerance.
Li Wan, Mengyao Zhang, Haiyue Guo, Yan Xu, Chenjie Xu, Fan Hu, Yinbing Pan, Xian Wang, Wentao Liu, Chun‐Yi Jiang   +9 more
wiley   +1 more source

In Vitro Maturation of Bone Marrow-Derived Dendritic Cells via STING Activation for T Cell Priming. [PDF]

Cancers (Basel)
Buyuk B, Ye K.
europepmc   +1 more source

The Vitamin D Receptor Agonist BXL-01-0029 as a Potential New Pharmacological Tool for the Treatment of Inflammatory Myopathies

, 2013
Luigi Di Luigi, Mariangela Sottili, Cristina Antinozzi, Gabriella Barbara Vannelli, Francesco Romanelli, Valeria Riccieri, Guido Valesini, Andrea Lenzi, Clara Crescioli   +8 more
openalex   +2 more sources

The G Protein–Biased κ-Opioid Receptor Agonist RB-64 Is Analgesic with a Unique Spectrum of Activities In Vivo

Journal of Pharmacology and Experimental Therapeutics, 2015
K. White, J. E. Robinson, Hu Zhu, Jeffrey F. DiBerto, Pr Polepally, J. Zjawiony, D. Nichols, C. Malanga, B. Roth   +8 more
semanticscholar   +1 more source

Targeted Expansion of Treg Cells to Induce Immune Tolerance after Kidney Transplantation

Advanced Science, EarlyView.
A dual‐targeting nanoparticle platform that selectively engages graft stromal cells via CD248 receptors while employing kidney‐ specific promoters (NPHS2) to drive localized IL‐ 2/TGF‐βexpression is developed. This approach achieves three therapeutic objectives:1) intragraft Treg polarization without systemic cytokine exposure;2) reduced dependence on ...
Tong Lu, Hongtao Song, Limin He, Zhihao Hu, Yu Li, Chao Xu, Shaojie Liu, Jun Jiang, Yike Zhou, Zhengxuan Li, Zeyu Li, Keying Zhang, Shuaijun Ma, Ruochen Qi, Shichao Han, Changhong Shi, Weihong Wen, Donghui Han, Weijun Qin   +18 more
wiley   +1 more source

Improved nonclinical pharmacokinetics and biodistribution of a new PPAR pan-agonist and COX inhibitor in nanocapsule formulation

, 2015
Giani Martins Garcia, Líliam Teixeira Oliveira, Ivan da Rocha Pitta, Maria do Carmo Alves de Lima, José Mário Carneiro Vilela, Margareth Spangler Andrade, Dulcinéia Saes Parra Abdalla, Vanessa Carla Furtado Mosqueira   +7 more
openalex   +2 more sources

Changes in the levels of inositol phosphates after agonist-dependent hydrolysis of membrane phosphoinositides.

Biochemical Journal, 1983
M. Berridge, R. Dawson, C. Downes, J. P. Heslop, R. Irvine   +4 more
semanticscholar   +1 more source

Smohaze‐Upregulated RFWD3 Competes with TRIM24 to Stabilize TREX1 and Reduce Cytosolic dsDNA in Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
The E3 ubiquitin ligase RFWD3 binds the exonuclease TREX1 and protects it from TRIM24‐mediated ubiquitination and degradation, leading to the eradication of intracellular dsDNA, inhibition of the cGAS‐STING pathway, and immunosuppressive microenvironment of lung cancer.
Xue‐Yan Shi, Yu‐Ke Shen, Meng‐Yao Lv, Yu Sun, Yong‐Fang Lin, Zheng Wang, Xiao‐Liang Jie, Zheng Liu, Yang‐Tong Liu, Yang‐Xin Fu, Zhenhua Ren, Gui‐Zhen Wang, Guang‐Biao Zhou   +12 more
wiley   +1 more source

Tumor recurrence risk following different COS regimens in infertile women with borderline ovarian tumors: impact on IVF outcomes. [PDF]

J Ovarian Res
Liang L, Li Y, Zhen XM, Yan J, Song XL, Li R.   +5 more
europepmc   +1 more source